整合生物学期刊网

应用天然产物 ›› 2020, Vol. 10 ›› Issue (2): 89-100.DOI: 10.1007/s13659-020-00239-z

• ORIGINAL ARTICLES • 上一篇    下一篇

Irlactane and Tremulane Sesquiterpenes from the Cultures of the Medicinal Fungus Irpex lacteus HFG1102

He-Ping Chen1, Xu Ji2, Zheng-Hui Li1, Tao Feng1, Ji-Kai Liu1   

  1. 1 School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China;
    2 School of Chemical Science and Technology, Yunnan University, Kunming 650091, People's Republic of China
  • 收稿日期:2020-01-09 修回日期:2020-03-26 出版日期:2020-04-24 发布日期:2020-05-06
  • 通讯作者: Ji-Kai Liu
  • 基金资助:
    This work was financially supported by National Natural Science Foundation of China (Nos.81903512, 21961142008). We thank Analytical & Measuring Center, School of Pharmaceutical Sciences, South-Central University for Nationalities for MS and NMR spectra tests.

Irlactane and Tremulane Sesquiterpenes from the Cultures of the Medicinal Fungus Irpex lacteus HFG1102

He-Ping Chen1, Xu Ji2, Zheng-Hui Li1, Tao Feng1, Ji-Kai Liu1   

  1. 1 School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China;
    2 School of Chemical Science and Technology, Yunnan University, Kunming 650091, People's Republic of China
  • Received:2020-01-09 Revised:2020-03-26 Online:2020-04-24 Published:2020-05-06
  • Contact: Ji-Kai Liu
  • Supported by:
    This work was financially supported by National Natural Science Foundation of China (Nos.81903512, 21961142008). We thank Analytical & Measuring Center, School of Pharmaceutical Sciences, South-Central University for Nationalities for MS and NMR spectra tests.

摘要: A new irlactane-type, namely irlactin K (1), and 22 tremulane-type sesquiterpenes including fourteen previously undescribed ones, namely irpexolactins A-N (2-15), and a known irlactane-type sesquiterpenoid, were isolated from the fermentation broth of the medicinal fungus Irpex lacteus HFG1102. The structures of all the isolates were characterized by extensive spectroscopic methods, including 1D and 2D NMR and MS spectroscopic analysis. The absolute configurations of irlactin K and the known compound conocenol B (20) were established by single-crystal X-ray diffraction analysis. The vasorelaxant effects of irlactin K (1), irpexolactins A (2), C (4), K (12), and irlactam (22) were evaluated.

关键词: Irpex lacteus, Meruliaceae, Irlactane, Tremulane, Sesquiterpene

Abstract: A new irlactane-type, namely irlactin K (1), and 22 tremulane-type sesquiterpenes including fourteen previously undescribed ones, namely irpexolactins A-N (2-15), and a known irlactane-type sesquiterpenoid, were isolated from the fermentation broth of the medicinal fungus Irpex lacteus HFG1102. The structures of all the isolates were characterized by extensive spectroscopic methods, including 1D and 2D NMR and MS spectroscopic analysis. The absolute configurations of irlactin K and the known compound conocenol B (20) were established by single-crystal X-ray diffraction analysis. The vasorelaxant effects of irlactin K (1), irpexolactins A (2), C (4), K (12), and irlactam (22) were evaluated.

Key words: Irpex lacteus, Meruliaceae, Irlactane, Tremulane, Sesquiterpene