Irpexoates A-D, Four Triterpenoids with Malonyl Modifications from the Fruiting Bodies of the Medicinal Fungus Irpex lacteus

doi:10.1007/s13659-018-0160-3

应用天然产物 ›› 2018, Vol. 8 ›› Issue (3): 171-176.DOI: 10.1007/s13659-018-0160-3

• ORIGINAL ARTICLE • 上一篇下一篇

Irpexoates A-D, Four Triterpenoids with Malonyl Modifications from the Fruiting Bodies of the Medicinal Fungus Irpex lacteus

Yang Tang^1,2,3, Zhen-Zhu Zhao², Zheng-Hui Li², Tao Feng², He-Ping Chen², Ji-Kai Liu²

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China;
3 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

收稿日期:2018-02-14 修回日期:2018-03-26 出版日期:2018-06-24 发布日期:2018-06-06
通讯作者: He-Ping Chen, Ji-Kai Liu
基金资助:
This work was financially supported by National Natural Science Foundation of China (81561148013), the Key Projects of Technological Innovation of Hubei Province (2016ACA138), and the Fundamental Research Funds for the Central University, South-Central University for Nationalities (CZT18014, CZT18013).

Irpexoates A-D, Four Triterpenoids with Malonyl Modifications from the Fruiting Bodies of the Medicinal Fungus Irpex lacteus

Yang Tang^1,2,3, Zhen-Zhu Zhao², Zheng-Hui Li², Tao Feng², He-Ping Chen², Ji-Kai Liu²

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China;
3 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

Received:2018-02-14 Revised:2018-03-26 Online:2018-06-24 Published:2018-06-06
Contact: He-Ping Chen, Ji-Kai Liu
Supported by:
This work was financially supported by National Natural Science Foundation of China (81561148013), the Key Projects of Technological Innovation of Hubei Province (2016ACA138), and the Fundamental Research Funds for the Central University, South-Central University for Nationalities (CZT18014, CZT18013).

摘要/Abstract

摘要： Four eburicane-type triterpenoids with malonyl modifications, namely irpexoates A-D (1-4), were isolated from the fruiting bodies of the medicinal fungus Irpex lacteus. The structures of the new compounds were established by extensive spectroscopic methods, including 1D and 2D NMR, HRESIMS spectroscopic analysis. Irpexoate B (2) displayed weak cytotoxicity against four human cancer cell lines (A-549, SMMC-7721, MCF-7, SW480) with IC₅₀ values varying from 22.9 to 34.0 μM, and irpexoate D (4) showed weak cytotoxicity against the human cancer cell line SW480 with an IC₅₀ value of 35.2 μM.

关键词: Irpex lacteus, Meruliaceae, Eburicane, Malonyl, Cytotoxicity

Abstract: Four eburicane-type triterpenoids with malonyl modifications, namely irpexoates A-D (1-4), were isolated from the fruiting bodies of the medicinal fungus Irpex lacteus. The structures of the new compounds were established by extensive spectroscopic methods, including 1D and 2D NMR, HRESIMS spectroscopic analysis. Irpexoate B (2) displayed weak cytotoxicity against four human cancer cell lines (A-549, SMMC-7721, MCF-7, SW480) with IC₅₀ values varying from 22.9 to 34.0 μM, and irpexoate D (4) showed weak cytotoxicity against the human cancer cell line SW480 with an IC₅₀ value of 35.2 μM.

Key words: Irpex lacteus, Meruliaceae, Eburicane, Malonyl, Cytotoxicity

Yang Tang, Zhen-Zhu Zhao, Zheng-Hui Li, Tao Feng, He-Ping Chen, Ji-Kai Liu. Irpexoates A-D, Four Triterpenoids with Malonyl Modifications from the Fruiting Bodies of the Medicinal Fungus Irpex lacteus[J]. 应用天然产物, 2018, 8(3): 171-176.

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Irpexoates A-D, Four Triterpenoids with Malonyl Modifications from the Fruiting Bodies of the Medicinal Fungus Irpex lacteus

Irpexoates A-D, Four Triterpenoids with Malonyl Modifications from the Fruiting Bodies of the Medicinal Fungus Irpex lacteus

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