Compounds from African Medicinal Plants with Activities Against Selected Parasitic Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis

doi:10.1007/s13659-018-0165-y

应用天然产物 ›› 2018, Vol. 8 ›› Issue (3): 151-169.DOI: 10.1007/s13659-018-0165-y

Compounds from African Medicinal Plants with Activities Against Selected Parasitic Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis

Conrad V. Simoben¹, Fidele Ntie-Kang^1,2, Sergi H. Akone^3,4, Wolfgang Sippl¹

1 Institute of Pharmacy, Martin-Luther University of HalleWittenberg, Wolfgang-Langenbeck-Str. 4, 06120 Halle(Saale), Germany;
2 Department of Chemistry, Faculty of Science, University of Buea, P. O. Box 63, Buea 00237, Cameroon;
3 Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University, Universitaetsstrasse1, Geb. 26. 23, Duesseldorf 40225, Germany;
4 Department of Chemistry, Faculty of Science, University of Douala, PO Box 24157, Douala 00237, Cameroon

收稿日期:2018-02-22 修回日期:2018-04-26 出版日期:2018-06-24 发布日期:2018-06-06
通讯作者: Fidele Ntie-Kang

Compounds from African Medicinal Plants with Activities Against Selected Parasitic Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis

Conrad V. Simoben¹, Fidele Ntie-Kang^1,2, Sergi H. Akone^3,4, Wolfgang Sippl¹

1 Institute of Pharmacy, Martin-Luther University of HalleWittenberg, Wolfgang-Langenbeck-Str. 4, 06120 Halle(Saale), Germany;
2 Department of Chemistry, Faculty of Science, University of Buea, P. O. Box 63, Buea 00237, Cameroon;
3 Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University, Universitaetsstrasse1, Geb. 26. 23, Duesseldorf 40225, Germany;
4 Department of Chemistry, Faculty of Science, University of Douala, PO Box 24157, Douala 00237, Cameroon

Received:2018-02-22 Revised:2018-04-26 Online:2018-06-24 Published:2018-06-06
Contact: Fidele Ntie-Kang

摘要/Abstract

摘要： Parasitic diseases continue to represent a threat on a global scale, particularly among the poorest countries in the world. This is particularly because of the absence of vaccines, and in some cases, resistance against available drugs, currently being used for their treatment. In this review emphasis is laid on natural products and scaffolds from African medicinal plants (AMPs) for lead drug discovery and possible further development of drugs for the treatment of parasitic diseases. In the discussion, emphasis has been laid on alkaloids, terpenoids, quinones, flavonoids and narrower compound classes of compounds with micromolar range activities against Schistosoma, Trypanosoma and Leishmania species. In each subparagraph, emphasis is laid on the compound subclasses with most promising in vitro and/or in vivo activities of plant extracts and isolated compounds. Suggestions for future drug development from African medicinal plants have also been provided. This review covering 167 references, including 82 compounds, provides information published within two decades (1997-2017).

关键词: Leishmaniasis, Natural products, Parasitic diseases, Schistosomiasis Trypanosomiasis, African medicinal plants

Abstract: Parasitic diseases continue to represent a threat on a global scale, particularly among the poorest countries in the world. This is particularly because of the absence of vaccines, and in some cases, resistance against available drugs, currently being used for their treatment. In this review emphasis is laid on natural products and scaffolds from African medicinal plants (AMPs) for lead drug discovery and possible further development of drugs for the treatment of parasitic diseases. In the discussion, emphasis has been laid on alkaloids, terpenoids, quinones, flavonoids and narrower compound classes of compounds with micromolar range activities against Schistosoma, Trypanosoma and Leishmania species. In each subparagraph, emphasis is laid on the compound subclasses with most promising in vitro and/or in vivo activities of plant extracts and isolated compounds. Suggestions for future drug development from African medicinal plants have also been provided. This review covering 167 references, including 82 compounds, provides information published within two decades (1997-2017).

Key words: African medicinal plants, Leishmaniasis, Natural products, Parasitic diseases, Schistosomiasis Trypanosomiasis

Conrad V. Simoben, Fidele Ntie-Kang, Sergi H. Akone, Wolfgang Sippl. Compounds from African Medicinal Plants with Activities Against Selected Parasitic Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis[J]. 应用天然产物, 2018, 8(3): 151-169.

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Compounds from African Medicinal Plants with Activities Against Selected Parasitic Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis

Compounds from African Medicinal Plants with Activities Against Selected Parasitic Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis

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