Sesquilignans and sesquiterpenoid from the stem barks of Illicium simonsii and their anti-AChE activity

doi:10.1007/s13659-012-0026-z

应用天然产物 ›› 2012, Vol. 2 ›› Issue (3): 133-137.DOI: 10.1007/s13659-012-0026-z

• Regular Article • 上一篇

Sesquilignans and sesquiterpenoid from the stem barks of Illicium simonsii and their anti-AChE activity

Chuan-Fu DONG^a,b, Lei LIU^a,b, Huai-Rong LUO^a, Xiao-Nian LI^a, Zheng-Ye GUAN^a,b, Yi-Fen WANG^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100049, China

收稿日期:2012-03-25 修回日期:2012-05-16 出版日期:2012-06-24 发布日期:2018-02-11
通讯作者: Yi-Fen WANG,E-mail:wangyifen@mail.kib.ac.cn
基金资助:
This work was supported by the National Natural Science Foundation(20872148). The authors are grateful to the analytical group of the Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences for measuring NMR, MS, and IR data.

Sesquilignans and sesquiterpenoid from the stem barks of Illicium simonsii and their anti-AChE activity

Chuan-Fu DONG^a,b, Lei LIU^a,b, Huai-Rong LUO^a, Xiao-Nian LI^a, Zheng-Ye GUAN^a,b, Yi-Fen WANG^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100049, China

Received:2012-03-25 Revised:2012-05-16 Online:2012-06-24 Published:2018-02-11
Supported by:
This work was supported by the National Natural Science Foundation(20872148). The authors are grateful to the analytical group of the Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences for measuring NMR, MS, and IR data.

摘要/Abstract

摘要： Three new sesquilignans, 1-3, a new sesquiterpenoid, 4, and three known compounds were isolated from the stem barks of Illicium simonsii. The structures of new compounds(1-4) were elucidated by spectroscopic methods. A biosynthetic pathway was proposed for simonsienols A-C(1-3). Anti-AChE activity and anti-BuChE activity were evaluated for all compounds except for α-cadinol ethyl ether(4). As a result, isodunnianol(7) exhibited anti-AChE activity with an IC₅₀ value of 13.0 μM.

关键词: Illicium simonsii, sesquilignans, sesquiterpenoid, anti-AChE activity

Abstract: Three new sesquilignans, 1-3, a new sesquiterpenoid, 4, and three known compounds were isolated from the stem barks of Illicium simonsii. The structures of new compounds(1-4) were elucidated by spectroscopic methods. A biosynthetic pathway was proposed for simonsienols A-C(1-3). Anti-AChE activity and anti-BuChE activity were evaluated for all compounds except for α-cadinol ethyl ether(4). As a result, isodunnianol(7) exhibited anti-AChE activity with an IC₅₀ value of 13.0 μM.

Key words: Illicium simonsii, sesquilignans, sesquiterpenoid, anti-AChE activity

Chuan-Fu DONG, Lei LIU, Huai-Rong LUO, Xiao-Nian LI, Zheng-Ye GUAN, Yi-Fen WANG. Sesquilignans and sesquiterpenoid from the stem barks of Illicium simonsii and their anti-AChE activity[J]. 应用天然产物, 2012, 2(3): 133-137.

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Sesquilignans and sesquiterpenoid from the stem barks of Illicium simonsii and their anti-AChE activity

Sesquilignans and sesquiterpenoid from the stem barks of Illicium simonsii and their anti-AChE activity

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