Lycoplanines B-D, Three Lycopodium Alkaloids from Lycopodium complanatum

doi:10.1007/s13659-018-0161-2

应用天然产物 ›› 2018, Vol. 8 ›› Issue (3): 177-182.DOI: 10.1007/s13659-018-0161-2

• ORIGINAL ARTICLE • 上一篇下一篇

Lycoplanines B-D, Three Lycopodium Alkaloids from Lycopodium complanatum

Zhi-Jun Zhang^1,2, Qin-Feng Zhu^1,2, Jia Su¹, Xing-De Wu¹, Qin-Shi Zhao¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

收稿日期:2018-02-06 修回日期:2018-03-26 出版日期:2018-06-24 发布日期:2018-06-06
通讯作者: Qin-Shi Zhao
基金资助:
This work was financially supported by the NSFC-Joint Foundation of Yunnan Province (No.U1502223),the National Natural Science Foundation of China (Nos.81773611 and 21602227),the Science and Technology Program of Yunnan province (Nos.2016FB140 and 2015FB173).

Lycoplanines B-D, Three Lycopodium Alkaloids from Lycopodium complanatum

Zhi-Jun Zhang^1,2, Qin-Feng Zhu^1,2, Jia Su¹, Xing-De Wu¹, Qin-Shi Zhao¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

Received:2018-02-06 Revised:2018-03-26 Online:2018-06-24 Published:2018-06-06
Contact: Qin-Shi Zhao
Supported by:
This work was financially supported by the NSFC-Joint Foundation of Yunnan Province (No.U1502223),the National Natural Science Foundation of China (Nos.81773611 and 21602227),the Science and Technology Program of Yunnan province (Nos.2016FB140 and 2015FB173).

摘要/Abstract

摘要： A novel C₁₇N Lycopodium alkaloid (LA), lycoplanine B (1), containing an unusual formyl group, along with two new LAs, lycoplanines C (2) and D (3), were isolated from the whole plant of Lycopodium complanatum. Their structures were elucidated by extensive NMR techniques, including 1D-and 2D-NMR experiments, as well as comparing their spectral data with those of the known analogues. A possible biogenetic pathway for 1 was also proposed.

关键词: Lycopodium complanatum, Lycoplanines, Lycopodium alkaloids, Anti-AChE activity

Abstract: A novel C₁₇N Lycopodium alkaloid (LA), lycoplanine B (1), containing an unusual formyl group, along with two new LAs, lycoplanines C (2) and D (3), were isolated from the whole plant of Lycopodium complanatum. Their structures were elucidated by extensive NMR techniques, including 1D-and 2D-NMR experiments, as well as comparing their spectral data with those of the known analogues. A possible biogenetic pathway for 1 was also proposed.

Key words: Lycopodium complanatum, Lycoplanines, Lycopodium alkaloids, Anti-AChE activity

Zhi-Jun Zhang, Qin-Feng Zhu, Jia Su, Xing-De Wu, Qin-Shi Zhao. Lycoplanines B-D, Three Lycopodium Alkaloids from Lycopodium complanatum[J]. 应用天然产物, 2018, 8(3): 177-182.

Zhi-Jun Zhang, Qin-Feng Zhu, Jia Su, Xing-De Wu, Qin-Shi Zhao. Lycoplanines B-D, Three Lycopodium Alkaloids from Lycopodium complanatum[J]. Natural Products and Bioprospecting, 2018, 8(3): 177-182.

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Lycoplanines B-D, Three Lycopodium Alkaloids from Lycopodium complanatum

Lycoplanines B-D, Three Lycopodium Alkaloids from Lycopodium complanatum

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