New Secodaphnane-Type Alkaloids with Cytotoxic Activities from Daphniphyllum angustifolium Hutch

doi:10.1007/s13659-021-00309-w

Natural Products and Bioprospecting ›› 2021, Vol. 11 ›› Issue (4): 453-457.DOI: 10.1007/s13659-021-00309-w

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New Secodaphnane-Type Alkaloids with Cytotoxic Activities from Daphniphyllum angustifolium Hutch

Qing-Yun Lu^1,5, Jia-Hui Zhang^1,2, Ying-Yao Li^1,3, Xue-Xue Pu^1,4, Cui-Shan Zhang^1,5, Shuai Liu^1,5, Jia-Jia Wan^1,5, Ying-Tong Di¹, Xiao-Jiang Hao¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 School of Life Sciences, Southwest University, Chongqing 400715, China;
3 Yunnan University, Kunming, People's Republic of China;
4 Yunnan University of Traditional Chinese Medicine, Kunming, People's Republic of China;
5 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

Received:2021-04-01 Accepted:2021-05-04 Online:2021-07-30 Published:2021-08-24
Contact: Ying-Tong Di, Xiao-Jiang Hao
Supported by:
This work was financially supported by the National Natural Science Foundation of China (No. 31770392 to YTD), and the Science and Technology Program of Yunnan Province (2018ZF013 to YTD). The authors are grateful to the analytical group of the Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences, for recorded spectra.

New Secodaphnane-Type Alkaloids with Cytotoxic Activities from Daphniphyllum angustifolium Hutch

Qing-Yun Lu^1,5, Jia-Hui Zhang^1,2, Ying-Yao Li^1,3, Xue-Xue Pu^1,4, Cui-Shan Zhang^1,5, Shuai Liu^1,5, Jia-Jia Wan^1,5, Ying-Tong Di¹, Xiao-Jiang Hao¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 School of Life Sciences, Southwest University, Chongqing 400715, China;
3 Yunnan University, Kunming, People's Republic of China;
4 Yunnan University of Traditional Chinese Medicine, Kunming, People's Republic of China;
5 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

通讯作者: Ying-Tong Di, Xiao-Jiang Hao
基金资助:
This work was financially supported by the National Natural Science Foundation of China (No. 31770392 to YTD), and the Science and Technology Program of Yunnan Province (2018ZF013 to YTD). The authors are grateful to the analytical group of the Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences, for recorded spectra.

Abstract

Abstract: One new Daphniphyllum alkaloid, daphnioldhanol A (1), together with three known ones, were isolated from the stem part of Daphniphyllum angustifolium Hutch. Their structures were elucidated by spectroscopic methods and comparing with the literature data. Compound 2 is a new natural product, but known by synthesis as a racemate. Compound 1 exhibited week cytotoxic activity against Hela cell line with IC₅₀ of 31.9 μM.

Key words: Daphniphyllum angustifolium hutch, Secodaphnane-type, Daphnioldhanol A, Cytotoxic activity

摘要： One new Daphniphyllum alkaloid, daphnioldhanol A (1), together with three known ones, were isolated from the stem part of Daphniphyllum angustifolium Hutch. Their structures were elucidated by spectroscopic methods and comparing with the literature data. Compound 2 is a new natural product, but known by synthesis as a racemate. Compound 1 exhibited week cytotoxic activity against Hela cell line with IC₅₀ of 31.9 μM.

关键词: Daphniphyllum angustifolium hutch, Secodaphnane-type, Daphnioldhanol A, Cytotoxic activity

Qing-Yun Lu, Jia-Hui Zhang, Ying-Yao Li, Xue-Xue Pu, Cui-Shan Zhang, Shuai Liu, Jia-Jia Wan, Ying-Tong Di, Xiao-Jiang Hao. New Secodaphnane-Type Alkaloids with Cytotoxic Activities from Daphniphyllum angustifolium Hutch[J]. Natural Products and Bioprospecting, 2021, 11(4): 453-457.

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New Secodaphnane-Type Alkaloids with Cytotoxic Activities from Daphniphyllum angustifolium Hutch

New Secodaphnane-Type Alkaloids with Cytotoxic Activities from Daphniphyllum angustifolium Hutch

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