Psathyrellins A-E, Antibacterial Guanacastane Diterpenoids from Mushroom Psathyrella candolleana

doi:10.1007/s13659-021-00316-x

Natural Products and Bioprospecting ›› 2021, Vol. 11 ›› Issue (4): 447-452.DOI: 10.1007/s13659-021-00316-x

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Psathyrellins A-E, Antibacterial Guanacastane Diterpenoids from Mushroom Psathyrella candolleana

Han Wu¹, Hui-Xiang Yang², Zheng-Hui Li², Tao Feng^1,2, Ji-Kai Liu^1,2

1 Anhui Key Laboratory of Modern Chinese Materia Medica, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, People's Republic of China;
2 School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China

Received:2021-06-16 Accepted:2021-06-23 Online:2021-07-30 Published:2021-08-24
Contact: Tao Feng, Ji-Kai Liu
Supported by:
The work is financially supported by the National Key Research and Development Program of China (Grant No. 2017YFC1704007). The authors thank Analytical & Measuring Centre, South-Central University for Nationalities for the spectra measurements.

Psathyrellins A-E, Antibacterial Guanacastane Diterpenoids from Mushroom Psathyrella candolleana

Han Wu¹, Hui-Xiang Yang², Zheng-Hui Li², Tao Feng^1,2, Ji-Kai Liu^1,2

1 Anhui Key Laboratory of Modern Chinese Materia Medica, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, People's Republic of China;
2 School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China

通讯作者: Tao Feng, Ji-Kai Liu
基金资助:
The work is financially supported by the National Key Research and Development Program of China (Grant No. 2017YFC1704007). The authors thank Analytical & Measuring Centre, South-Central University for Nationalities for the spectra measurements.

Abstract

Abstract: Five previously undescribed guanacastane diterpenoids, namely psathyrellins A-E (1-5), were obtained from cultures of the mushroom Psathyrella candolleana. Their structures with absolute configurations were elucidated by extensive spectroscopic methods. Compounds 1-3 showed antibacterial activity against four strains with MIC values in a range of 16-128 μg/mL.

Key words: Psathyrella candolleana, Guanacastane diterpenoids, Antibacterial activity

摘要： Five previously undescribed guanacastane diterpenoids, namely psathyrellins A-E (1-5), were obtained from cultures of the mushroom Psathyrella candolleana. Their structures with absolute configurations were elucidated by extensive spectroscopic methods. Compounds 1-3 showed antibacterial activity against four strains with MIC values in a range of 16-128 μg/mL.

关键词: Psathyrella candolleana, Guanacastane diterpenoids, Antibacterial activity

Han Wu, Hui-Xiang Yang, Zheng-Hui Li, Tao Feng, Ji-Kai Liu. Psathyrellins A-E, Antibacterial Guanacastane Diterpenoids from Mushroom Psathyrella candolleana[J]. Natural Products and Bioprospecting, 2021, 11(4): 447-452.

Han Wu, Hui-Xiang Yang, Zheng-Hui Li, Tao Feng, Ji-Kai Liu. Psathyrellins A-E, Antibacterial Guanacastane Diterpenoids from Mushroom Psathyrella candolleana[J]. 应用天然产物, 2021, 11(4): 447-452.

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Psathyrellins A-E, Antibacterial Guanacastane Diterpenoids from Mushroom Psathyrella candolleana

Psathyrellins A-E, Antibacterial Guanacastane Diterpenoids from Mushroom Psathyrella candolleana

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