Chemical Constituents from Ethanoic Extracts of the Aerial Parts of Leea aequata L., a Traditional Folk Medicine of Myanmar

doi:10.1007/s13659-019-0209-y

Natural Products and Bioprospecting ›› 2019, Vol. 9 ›› Issue (3): 243-249.DOI: 10.1007/s13659-019-0209-y

• ORIGINAL ARTICLES • Previous Articles

Chemical Constituents from Ethanoic Extracts of the Aerial Parts of Leea aequata L., a Traditional Folk Medicine of Myanmar

Nay Lin Tun^1,2,3, Dong-Bao Hu⁴, Meng-Yuan Xia², Dong-Dong Zhang^1,2, Jun Yang², Thaung Naing Oo⁵, Yue-Hu Wang², Xue-Fei Yang^1,2,3

1 Southeast Asia Biodiversity Research Institute, Chinese Academy of Sciences, Yezin, Nay Pyi Taw 05282, Myanmar;
2 Key Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
3 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
4 College of Resources and Environment, Yuxi Normal University, Yuxi 653100, People's Republic of China;
5 Forest Research Institute, Yezin, Nay Pyi Taw 05282, Myanmar

Received:2019-03-21 Revised:2019-04-21 Online:2019-06-05 Published:2019-06-24
Contact: Yue-Hu Wang, Xue-Fei Yang
Supported by:
We thank Dr. Jie Cai at Kunming Institutes of Botany, Chinese Academy of Sciences, for collecting plant materials. This study was supported by the Southeast Asia Biodiversity Research Institute, Chinese Academy of Sciences (Grant Nos. 2015CASEABRIRG001 and Y4ZK111B01), and the International Partnership Program of Chinese Academy of Sciences (153631KYSB20160004).

Chemical Constituents from Ethanoic Extracts of the Aerial Parts of Leea aequata L., a Traditional Folk Medicine of Myanmar

Nay Lin Tun^1,2,3, Dong-Bao Hu⁴, Meng-Yuan Xia², Dong-Dong Zhang^1,2, Jun Yang², Thaung Naing Oo⁵, Yue-Hu Wang², Xue-Fei Yang^1,2,3

1 Southeast Asia Biodiversity Research Institute, Chinese Academy of Sciences, Yezin, Nay Pyi Taw 05282, Myanmar;
2 Key Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
3 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
4 College of Resources and Environment, Yuxi Normal University, Yuxi 653100, People's Republic of China;
5 Forest Research Institute, Yezin, Nay Pyi Taw 05282, Myanmar

通讯作者: Yue-Hu Wang, Xue-Fei Yang
基金资助:
We thank Dr. Jie Cai at Kunming Institutes of Botany, Chinese Academy of Sciences, for collecting plant materials. This study was supported by the Southeast Asia Biodiversity Research Institute, Chinese Academy of Sciences (Grant Nos. 2015CASEABRIRG001 and Y4ZK111B01), and the International Partnership Program of Chinese Academy of Sciences (153631KYSB20160004).

Abstract

Abstract: We aimed at reporting the chemical constituents and antimicrobial activities of Leea aequata L., a traditional folk medicine used in Myanmar for the treatment of wounds and skin diseases. A new neolignan, (7S,8R)-9'-O-acetylcedrusin (1), a new lactam, (3S,4S)-4-chloro-3-hydroxypiperidin-2-one (2), along with 21 known compounds, including five lignans (3-7), four flavonoid glycosides (8-11), and others (12-23), were isolated from the ethanoic extract of the aerial parts of L. aequata. The structures of the new compounds were determined by NMR, MS, and ECD spectra. For all the antimicrobial tests of the 23 compounds, only 3,4,5-trihydroxybenzoic acid ethyl ester (17) showed weak inhibitory activities against Escherichia coli and Salmonella enterica subsp. enterica.

Key words: Leea aequata, Vitaceae, Traditional medicines, Lignans, Flavonoids

摘要： We aimed at reporting the chemical constituents and antimicrobial activities of Leea aequata L., a traditional folk medicine used in Myanmar for the treatment of wounds and skin diseases. A new neolignan, (7S,8R)-9'-O-acetylcedrusin (1), a new lactam, (3S,4S)-4-chloro-3-hydroxypiperidin-2-one (2), along with 21 known compounds, including five lignans (3-7), four flavonoid glycosides (8-11), and others (12-23), were isolated from the ethanoic extract of the aerial parts of L. aequata. The structures of the new compounds were determined by NMR, MS, and ECD spectra. For all the antimicrobial tests of the 23 compounds, only 3,4,5-trihydroxybenzoic acid ethyl ester (17) showed weak inhibitory activities against Escherichia coli and Salmonella enterica subsp. enterica.

关键词: Leea aequata, Vitaceae, Traditional medicines, Lignans, Flavonoids

Nay Lin Tun, Dong-Bao Hu, Meng-Yuan Xia, Dong-Dong Zhang, Jun Yang, Thaung Naing Oo, Yue-Hu Wang, Xue-Fei Yang. Chemical Constituents from Ethanoic Extracts of the Aerial Parts of Leea aequata L., a Traditional Folk Medicine of Myanmar[J]. Natural Products and Bioprospecting, 2019, 9(3): 243-249.

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Chemical Constituents from Ethanoic Extracts of the Aerial Parts of Leea aequata L., a Traditional Folk Medicine of Myanmar

Chemical Constituents from Ethanoic Extracts of the Aerial Parts of Leea aequata L., a Traditional Folk Medicine of Myanmar

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