Five new limonoids isolated from Walsura robusta

doi:10.1007/s13659-023-00371-6

Natural Products and Bioprospecting ›› 2023, Vol. 13 ›› Issue (2): 7-7.DOI: 10.1007/s13659-023-00371-6

• Original Article • Next Articles

Five new limonoids isolated from Walsura robusta

Li Hou^1,2,4, Cui-Xuan Mei^1,3, Chun-Mao Yuan^1,5, Gui-Hua Tang¹, Duo-Zhi Chen¹, Qing Zhao², Hong-Ping He^1,2, Ming-Ming Cao¹, Xiao-Jiang Hao^1,5,6,7

1. State Key Laboratory of Photochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China;
2. School of Ethnic Medicine, and School of Chinese Materia Medical, Yunnan University of Chinese Medicine, Kunming, 650500, China;
3. University of Chinese Academy of Sciences, Beijing, 100049, China;
4. Bureau of Commerce and Market Supervision of Management Committee of Hunan Xiangjiang New Area, Changsha, 410205, China;
5. The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550014, China;
6. Research Unit of Chemical Biology of Natural Anti-Virus Products, Chinese Academy of Medical Sciences, Beijing, 100730, China;
7. Yunnan Characteristic Plant Extraction Laboratory, Kunming, 650106, China

Received:2023-01-13 Online:2023-05-18 Published:2023-04-24
Contact: Hong-Ping He,E-mail:hehongping@yahoo.com;Ming-Ming Cao,E-mail:caomingming@mail.kib.ac.cn;Xiao-Jiang Hao,E-mail:haoxj@mail.kib.ac.cn
Supported by:
This research was supported financially by grants from the National Natural Science Foundation of China (U1812403 to X.-J. Hao and 22177050 to M. Cao), Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform (2022YKZY001), Foundation of Central Asian Drug Discovery and Development Center of Chinese Academy of Sciences (CAM202103, China), and Youth Innovation Promotion Association CAS to M. Cao (2022-2026).

Five new limonoids isolated from Walsura robusta

Li Hou^1,2,4, Cui-Xuan Mei^1,3, Chun-Mao Yuan^1,5, Gui-Hua Tang¹, Duo-Zhi Chen¹, Qing Zhao², Hong-Ping He^1,2, Ming-Ming Cao¹, Xiao-Jiang Hao^1,5,6,7

1. State Key Laboratory of Photochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China;
2. School of Ethnic Medicine, and School of Chinese Materia Medical, Yunnan University of Chinese Medicine, Kunming, 650500, China;
3. University of Chinese Academy of Sciences, Beijing, 100049, China;
4. Bureau of Commerce and Market Supervision of Management Committee of Hunan Xiangjiang New Area, Changsha, 410205, China;
5. The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550014, China;
6. Research Unit of Chemical Biology of Natural Anti-Virus Products, Chinese Academy of Medical Sciences, Beijing, 100730, China;
7. Yunnan Characteristic Plant Extraction Laboratory, Kunming, 650106, China

通讯作者: Hong-Ping He,E-mail:hehongping@yahoo.com;Ming-Ming Cao,E-mail:caomingming@mail.kib.ac.cn;Xiao-Jiang Hao,E-mail:haoxj@mail.kib.ac.cn
基金资助:
This research was supported financially by grants from the National Natural Science Foundation of China (U1812403 to X.-J. Hao and 22177050 to M. Cao), Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform (2022YKZY001), Foundation of Central Asian Drug Discovery and Development Center of Chinese Academy of Sciences (CAM202103, China), and Youth Innovation Promotion Association CAS to M. Cao (2022-2026).

Abstract

Abstract: Five new toosendanin limonoids with highly oxidative furan ring walsurobustones A-D (1-4), and one new furan ring degraded limonoid walsurobustone E (5) together with one known compound toonapubesic acid B (6) were isolated from the leaves of Walsura robusta. Their structures were elucidated by NMR and MS data. Especially, the absolute configuration of toonapubesic acid B (6) was confirmed by X-ray diffraction study. Compounds 1-6 exhibited good cytotoxicity against the cancer cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480.

Key words: Limonoids, Tetranortriterpenoids, Walsura robusta, Cytotoxicity

摘要： Five new toosendanin limonoids with highly oxidative furan ring walsurobustones A-D (1-4), and one new furan ring degraded limonoid walsurobustone E (5) together with one known compound toonapubesic acid B (6) were isolated from the leaves of Walsura robusta. Their structures were elucidated by NMR and MS data. Especially, the absolute configuration of toonapubesic acid B (6) was confirmed by X-ray diffraction study. Compounds 1-6 exhibited good cytotoxicity against the cancer cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480.

关键词: Limonoids, Tetranortriterpenoids, Walsura robusta, Cytotoxicity

Li Hou, Cui-Xuan Mei, Chun-Mao Yuan, Gui-Hua Tang, Duo-Zhi Chen, Qing Zhao, Hong-Ping He, Ming-Ming Cao, Xiao-Jiang Hao. Five new limonoids isolated from Walsura robusta[J]. Natural Products and Bioprospecting, 2023, 13(2): 7-7.

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Five new limonoids isolated from Walsura robusta

Five new limonoids isolated from Walsura robusta

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