Novel triterpenoids from Ganoderma resinaceum attenuate UV-induced photoaging via modulating Nrf2 and MAPK signaling pathways

doi:10.1007/s13659-025-00558-z

Natural Products and Bioprospecting ›› 2026, Vol. 16 ›› Issue (1): 5-5.DOI: 10.1007/s13659-025-00558-z

• Original Article • Previous Articles Next Articles

Novel triterpenoids from Ganoderma resinaceum attenuate UV-induced photoaging via modulating Nrf2 and MAPK signaling pathways

Yi Luo^1,2,3, Xiao-Cui Liu^1,2,3, Yu-Jie Li^1,2,3, Ming-Hua Qiu^1,2,3, Xing-Rong Peng^1,2,3

1. State Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2. Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, 650204 Yunnan, China;
3. University of Chinese Academy of Sciences, Beijing 100049, China

Received:2025-07-15 Online:2026-03-25 Published:2026-02-14
Contact: Ming-Hua Qiu,E-mail:mhchiu@mail.kib.ac.cn;Xing-Rong Peng,E-mail:pengxingrong@mail.kib.ac.cn
Supported by:
This study was financially supported by the Basic Research Program of Yunnan Province (202301AT070332), the Yunnan Revitalization Talent Support Program “Young Talent” Project (XDYC-QNRC-2022-0480).

Novel triterpenoids from Ganoderma resinaceum attenuate UV-induced photoaging via modulating Nrf2 and MAPK signaling pathways

Yi Luo^1,2,3, Xiao-Cui Liu^1,2,3, Yu-Jie Li^1,2,3, Ming-Hua Qiu^1,2,3, Xing-Rong Peng^1,2,3

1. State Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2. Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, 650204 Yunnan, China;
3. University of Chinese Academy of Sciences, Beijing 100049, China

通讯作者: Ming-Hua Qiu,E-mail:mhchiu@mail.kib.ac.cn;Xing-Rong Peng,E-mail:pengxingrong@mail.kib.ac.cn
基金资助:
This study was financially supported by the Basic Research Program of Yunnan Province (202301AT070332), the Yunnan Revitalization Talent Support Program “Young Talent” Project (XDYC-QNRC-2022-0480).

Abstract

Abstract: As a dual-purpose medicinal and edible mushroom, Ganoderma species have garnered significant interest in both the food, cosmetics and pharmaceutical industries. To further substantiate its traditional and functional uses, we conducted a systematic phytochemical study of Ganoderma resinaceum fruiting bodies, isolating 43 lanostane-type triterpenoids. Among these, 16 were identified as new compounds (1-11, 15, 31, 35, 37, and 42). Compound 1 represents the first reported C₂₉ lanostane triterpenoid featuring a 21,24-cyclo five membered carbon ring fraction. The spectroscopic (1D/2D NMR, ESIMS) and X-ray crystallographic analyses confirmed their structures. Among these, compounds 2-4, 13, 17, 35, 36, and 42 exhibited potent antioxidant activity by suppressing UV-induced ROS in skin keratinocytes. The most active compound, 42, reduced ROS and malondialdehyde (MDA) levels, enhanced antioxidant defenses (superoxide dismutase, SOD; hydroxyproline), and suppressed matrix metalloproteinases (MMPs) through activating Nrf2 pathway and suppressing MAPK signaling. These results position G. resinaceum triterpenoids, particularly compound 42, as multifunctional natural antioxidants with applications in functional foods for oxidative stress management or skin-protective formulations.

Key words: Ganoderma resinaceum, Lanostane-type triterpenoids, Nrf2, MAPK signaling pathway, Skin photoaging

摘要： As a dual-purpose medicinal and edible mushroom, Ganoderma species have garnered significant interest in both the food, cosmetics and pharmaceutical industries. To further substantiate its traditional and functional uses, we conducted a systematic phytochemical study of Ganoderma resinaceum fruiting bodies, isolating 43 lanostane-type triterpenoids. Among these, 16 were identified as new compounds (1-11, 15, 31, 35, 37, and 42). Compound 1 represents the first reported C₂₉ lanostane triterpenoid featuring a 21,24-cyclo five membered carbon ring fraction. The spectroscopic (1D/2D NMR, ESIMS) and X-ray crystallographic analyses confirmed their structures. Among these, compounds 2-4, 13, 17, 35, 36, and 42 exhibited potent antioxidant activity by suppressing UV-induced ROS in skin keratinocytes. The most active compound, 42, reduced ROS and malondialdehyde (MDA) levels, enhanced antioxidant defenses (superoxide dismutase, SOD; hydroxyproline), and suppressed matrix metalloproteinases (MMPs) through activating Nrf2 pathway and suppressing MAPK signaling. These results position G. resinaceum triterpenoids, particularly compound 42, as multifunctional natural antioxidants with applications in functional foods for oxidative stress management or skin-protective formulations.

关键词: Ganoderma resinaceum, Lanostane-type triterpenoids, Nrf2, MAPK signaling pathway, Skin photoaging

Yi Luo, Xiao-Cui Liu, Yu-Jie Li, Ming-Hua Qiu, Xing-Rong Peng. Novel triterpenoids from Ganoderma resinaceum attenuate UV-induced photoaging via modulating Nrf2 and MAPK signaling pathways[J]. Natural Products and Bioprospecting, 2026, 16(1): 5-5.

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Novel triterpenoids from Ganoderma resinaceum attenuate UV-induced photoaging via modulating Nrf2 and MAPK signaling pathways

Novel triterpenoids from Ganoderma resinaceum attenuate UV-induced photoaging via modulating Nrf2 and MAPK signaling pathways

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