The bibenzyl derivatives of Dendrobium officinale prevent UV-B irradiation induced photoaging via SIRT3

doi:10.1007/s13659-022-00323-6

Natural Products and Bioprospecting ›› 2022, Vol. 12 ›› Issue (1): 1-11.DOI: 10.1007/s13659-022-00323-6

• ORIGINAL ARTICLES •

The bibenzyl derivatives of Dendrobium officinale prevent UV-B irradiation induced photoaging via SIRT3

Ding-kang Chen^1,2,3, Hui-yan Shao¹, Liu Yang^1,2, Jiang-miao Hu^1,2,3

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2 R&D Center of Dr. Plant, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
3 University of Chinese Academy of Science, Beijing 100049, China

Received:2021-10-28 Revised:2021-12-23 Online:2022-03-12 Published:2022-02-24
Contact: Liu Yang, Jiang-miao Hu
Supported by:
This work was financially supported by Biological Resources Programme, Chinese Academy of Sciences (Grant No. KFJ-BRP-007-019); National Natural Science Foundation of China (No. 32170407) and Beijing DR PLANT Biotechnology Co., Ltd.

The bibenzyl derivatives of Dendrobium officinale prevent UV-B irradiation induced photoaging via SIRT3

Ding-kang Chen^1,2,3, Hui-yan Shao¹, Liu Yang^1,2, Jiang-miao Hu^1,2,3

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2 R&D Center of Dr. Plant, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
3 University of Chinese Academy of Science, Beijing 100049, China

通讯作者: Liu Yang, Jiang-miao Hu
基金资助:
This work was financially supported by Biological Resources Programme, Chinese Academy of Sciences (Grant No. KFJ-BRP-007-019); National Natural Science Foundation of China (No. 32170407) and Beijing DR PLANT Biotechnology Co., Ltd.

Abstract

Abstract: Dendrobium officinale is a valuable medicinal herb that is widely used in traditional Chinese medicine. The chemical constituents of D. officinale have attracted much attention and a large number of compounds have been reported including many bibenzyl derivatives. 13 bibenzyl derivatives from D. officinale were sent for molecular docking, surface plasmon resonance (SPR) assay and after detection of Mn-SOD and SIRT3 activities in or not in HaCaT cells, it was concluded that bibenzyl derivatives did not directly activate Mn-SOD but promoted SIRT3 proteins. In addition, HaCaT cells were irradiated with UV-B to induce an oxidative stress model in vitro to further verify the effect of bibenzyl derivatives. The results show that bibenzyl derivatives could directly bind to SIRT3, enhance the deacetylation and then activate Mn-SOD, so as to protect UV-B induced skin photoaging.

Key words: Dendrobium officinale, Bibenzyl derivatives, Skin photoaging, Oxidative stress, SIRT3

摘要： Dendrobium officinale is a valuable medicinal herb that is widely used in traditional Chinese medicine. The chemical constituents of D. officinale have attracted much attention and a large number of compounds have been reported including many bibenzyl derivatives. 13 bibenzyl derivatives from D. officinale were sent for molecular docking, surface plasmon resonance (SPR) assay and after detection of Mn-SOD and SIRT3 activities in or not in HaCaT cells, it was concluded that bibenzyl derivatives did not directly activate Mn-SOD but promoted SIRT3 proteins. In addition, HaCaT cells were irradiated with UV-B to induce an oxidative stress model in vitro to further verify the effect of bibenzyl derivatives. The results show that bibenzyl derivatives could directly bind to SIRT3, enhance the deacetylation and then activate Mn-SOD, so as to protect UV-B induced skin photoaging.

关键词: Dendrobium officinale, Bibenzyl derivatives, Skin photoaging, Oxidative stress, SIRT3

Ding-kang Chen, Hui-yan Shao, Liu Yang, Jiang-miao Hu. The bibenzyl derivatives of Dendrobium officinale prevent UV-B irradiation induced photoaging via SIRT3[J]. Natural Products and Bioprospecting, 2022, 12(1): 1-11.

Ding-kang Chen, Hui-yan Shao, Liu Yang, Jiang-miao Hu. The bibenzyl derivatives of Dendrobium officinale prevent UV-B irradiation induced photoaging via SIRT3[J]. 应用天然产物, 2022, 12(1): 1-11.

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The bibenzyl derivatives of Dendrobium officinale prevent UV-B irradiation induced photoaging via SIRT3

The bibenzyl derivatives of Dendrobium officinale prevent UV-B irradiation induced photoaging via SIRT3

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