Widely targeted metabolomics analysis reveals differences in volatile metabolites among four Angelica species

doi:10.1007/s13659-024-00485-5

Natural Products and Bioprospecting ›› 2025, Vol. 15 ›› Issue (1): 2-2.DOI: 10.1007/s13659-024-00485-5

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Widely targeted metabolomics analysis reveals differences in volatile metabolites among four Angelica species

Jiaojiao Ji^1,2, Lanlan Zang^1,3, Tingting Lu^1,4,5, Cheng Li¹, Xiaoxu Han¹, Soo-Rang Lee⁶, Li Wang^1,7

1. Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, No 7, Peangfei Road, Dapeng District, Shenzhen, 518120, China;
2. College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China;
3. Zhengzhou Research Base, State Key Laboratory of Cotton Biology, School of Agricultural Sciences, Zhengzhou University, Zhengzhou, 450001, China;
4. State Key Laboratory of Crop Stress Adaptation and Improvement, School of Life Sciences, Henan University, Kaifeng, 475004, China;
5. Shenzhen Research Institute of Henan University, Shenzhen, 518000, China;
6. Department of Biology Education, College of Education, Chosun University, Gwangju, 61452, South Korea;
7. Kunpeng Institute of Modern Agriculture at Foshan, Foshan, 528200, China

Received:2024-08-31 Accepted:2024-11-23 Online:2025-02-15 Published:2025-02-24
Contact: Li WANG,E-mail:wangli03@caas.cn
Supported by:
This work was supported by the National Science Foundation of China, Grant 32470245.

Widely targeted metabolomics analysis reveals differences in volatile metabolites among four Angelica species

Jiaojiao Ji^1,2, Lanlan Zang^1,3, Tingting Lu^1,4,5, Cheng Li¹, Xiaoxu Han¹, Soo-Rang Lee⁶, Li Wang^1,7

1. Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, No 7, Peangfei Road, Dapeng District, Shenzhen, 518120, China;
2. College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China;
3. Zhengzhou Research Base, State Key Laboratory of Cotton Biology, School of Agricultural Sciences, Zhengzhou University, Zhengzhou, 450001, China;
4. State Key Laboratory of Crop Stress Adaptation and Improvement, School of Life Sciences, Henan University, Kaifeng, 475004, China;
5. Shenzhen Research Institute of Henan University, Shenzhen, 518000, China;
6. Department of Biology Education, College of Education, Chosun University, Gwangju, 61452, South Korea;
7. Kunpeng Institute of Modern Agriculture at Foshan, Foshan, 528200, China

通讯作者: Li WANG,E-mail:wangli03@caas.cn
基金资助:
This work was supported by the National Science Foundation of China, Grant 32470245.

Abstract

Abstract: Angelica L. has attracted global interest for its traditional medicinal uses and commercial values. However, few studies have focused on the metabolomic differences among the Angelica species. In this study, widely targeted metabolomics based on gas chromatography-tandem mass spectrometry was employed to analyze the metabolomes of four Angelica species (Angelica sinensis (Oliv.) Diels (A. sinensis), Angelica biserrata (R.H.Shan & Yuan) C.Q.Yuan & R.H.Shan (A. biserrata), Angelica dahurica (Hoffm.) Benth. & Hook.f. ex Franch. & Sav. (A. dahurica) and Angelica keiskei Koidz. (A. keiskei)). A total of 698 volatile metabolites were identified and classified into fifteen different categories. The metabolomic analysis indicated that 7-hydroxycoumarin and Z-ligustilide accumulated at significantly higher levels in A. sinensis, whereas bornyl acetate showed the opposite pattern. Furthermore, a high correspondence between the dendrogram of metabolite contents and phylogenetic positions of the four species. This study provides a comprehensive biochemical map for the exploitation, application and development of the Angelica species as medicinal plants or health-related dietary supplements.

Key words: Angelica, Volatile metabolites, Chinese traditional medicine, Phylogeny

摘要： Angelica L. has attracted global interest for its traditional medicinal uses and commercial values. However, few studies have focused on the metabolomic differences among the Angelica species. In this study, widely targeted metabolomics based on gas chromatography-tandem mass spectrometry was employed to analyze the metabolomes of four Angelica species (Angelica sinensis (Oliv.) Diels (A. sinensis), Angelica biserrata (R.H.Shan & Yuan) C.Q.Yuan & R.H.Shan (A. biserrata), Angelica dahurica (Hoffm.) Benth. & Hook.f. ex Franch. & Sav. (A. dahurica) and Angelica keiskei Koidz. (A. keiskei)). A total of 698 volatile metabolites were identified and classified into fifteen different categories. The metabolomic analysis indicated that 7-hydroxycoumarin and Z-ligustilide accumulated at significantly higher levels in A. sinensis, whereas bornyl acetate showed the opposite pattern. Furthermore, a high correspondence between the dendrogram of metabolite contents and phylogenetic positions of the four species. This study provides a comprehensive biochemical map for the exploitation, application and development of the Angelica species as medicinal plants or health-related dietary supplements.

关键词: Angelica, Volatile metabolites, Chinese traditional medicine, Phylogeny

Jiaojiao Ji, Lanlan Zang, Tingting Lu, Cheng Li, Xiaoxu Han, Soo-Rang Lee, Li Wang. Widely targeted metabolomics analysis reveals differences in volatile metabolites among four Angelica species[J]. Natural Products and Bioprospecting, 2025, 15(1): 2-2.

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Widely targeted metabolomics analysis reveals differences in volatile metabolites among four Angelica species

Widely targeted metabolomics analysis reveals differences in volatile metabolites among four Angelica species

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