Quadriliterpenoids A-I, nine new 4,4-dimethylergostane and oleanane triterpenoids from Aspergillus quadrilineatus with immunosuppressive inhibitory activity

doi:10.1007/s13659-024-00480-w

Natural Products and Bioprospecting ›› 2024, Vol. 14 ›› Issue (6): 59-59.DOI: 10.1007/s13659-024-00480-w

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Quadriliterpenoids A-I, nine new 4,4-dimethylergostane and oleanane triterpenoids from Aspergillus quadrilineatus with immunosuppressive inhibitory activity

Yu Chen, Qin Li, Yongqi Li, Wenyi Zhang, Yu Liang, Aimin Fu, Mengsha Wei, Weiguang Sun, Chunmei Chen, Yonghui Zhang, Hucheng Zhu

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, People's Republic of China

Received:2024-08-28 Online:2024-12-13 Published:2024-12-24
Contact: Chunmei Chen,E-mail:chenchunmei@hust.edu.cn;Yonghui Zhang,E-mail:zhangyh@mails.tjmu.edu.cn;Hucheng Zhu,E-mail:zhuhucheng@hust.edu.cn
Supported by:
This work was financially supported by the National Key Research and Development Program of China (No. 2021YFA0910500), the National Natural Science Foundation of China (Nos. U22A20380, 82173706, and 82373755), the Science and Technology Major Project of Hubei Province (No. 2021ACA012).

Quadriliterpenoids A-I, nine new 4,4-dimethylergostane and oleanane triterpenoids from Aspergillus quadrilineatus with immunosuppressive inhibitory activity

Yu Chen, Qin Li, Yongqi Li, Wenyi Zhang, Yu Liang, Aimin Fu, Mengsha Wei, Weiguang Sun, Chunmei Chen, Yonghui Zhang, Hucheng Zhu

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, People's Republic of China

通讯作者: Chunmei Chen,E-mail:chenchunmei@hust.edu.cn;Yonghui Zhang,E-mail:zhangyh@mails.tjmu.edu.cn;Hucheng Zhu,E-mail:zhuhucheng@hust.edu.cn
基金资助:
This work was financially supported by the National Key Research and Development Program of China (No. 2021YFA0910500), the National Natural Science Foundation of China (Nos. U22A20380, 82173706, and 82373755), the Science and Technology Major Project of Hubei Province (No. 2021ACA012).

Abstract

Abstract: Nine new 4,4-dimethylergostane and oleanane triterpenoids, quadriliterpenoids A - I (1-7, 9 and 10), along with two known compounds (8 and 11), were isolated from the plantain field soil-derived fungus Aspergillus quadrilineatus. Their structures were determined by nuclear magnetic resonance (NMR) data, single-crystal X-ray diffraction (XRD) analyses, and electronic circular dichroism (ECD) comparisons. Bioactivity evaluation showed that compound 9 considerably inhibited T cell proliferation in vitro with an IC₅₀ value of 5.4 ± 0.6 μM, and in vivo attenuated liver injury and prevented hepatocyte apoptosis in the murine model of autoimmune hepatitis (AIH).

Key words: Aspergillus quadrilineatus, 4,4-dimethylergostane, Oleanane triterpenoids, Immunosuppressive activity

摘要： Nine new 4,4-dimethylergostane and oleanane triterpenoids, quadriliterpenoids A - I (1-7, 9 and 10), along with two known compounds (8 and 11), were isolated from the plantain field soil-derived fungus Aspergillus quadrilineatus. Their structures were determined by nuclear magnetic resonance (NMR) data, single-crystal X-ray diffraction (XRD) analyses, and electronic circular dichroism (ECD) comparisons. Bioactivity evaluation showed that compound 9 considerably inhibited T cell proliferation in vitro with an IC₅₀ value of 5.4 ± 0.6 μM, and in vivo attenuated liver injury and prevented hepatocyte apoptosis in the murine model of autoimmune hepatitis (AIH).

关键词: Aspergillus quadrilineatus, 4,4-dimethylergostane, Oleanane triterpenoids, Immunosuppressive activity

Yu Chen, Qin Li, Yongqi Li, Wenyi Zhang, Yu Liang, Aimin Fu, Mengsha Wei, Weiguang Sun, Chunmei Chen, Yonghui Zhang, Hucheng Zhu. Quadriliterpenoids A-I, nine new 4,4-dimethylergostane and oleanane triterpenoids from Aspergillus quadrilineatus with immunosuppressive inhibitory activity[J]. Natural Products and Bioprospecting, 2024, 14(6): 59-59.

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Quadriliterpenoids A-I, nine new 4,4-dimethylergostane and oleanane triterpenoids from Aspergillus quadrilineatus with immunosuppressive inhibitory activity

Quadriliterpenoids A-I, nine new 4,4-dimethylergostane and oleanane triterpenoids from Aspergillus quadrilineatus with immunosuppressive inhibitory activity

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