Silvaticusins A-D: ent-kaurane diterpenoids and a cyclobutane-containing ent-kaurane dimer from Isodon silvaticus

doi:10.1007/s13659-024-00465-9

Natural Products and Bioprospecting ›› 2024, Vol. 14 ›› Issue (5): 45-45.DOI: 10.1007/s13659-024-00465-9

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Silvaticusins A-D: ent-kaurane diterpenoids and a cyclobutane-containing ent-kaurane dimer from Isodon silvaticus

Qi-Xiu Hai^1,2, Kun Hu², Su-Ping Chen², Yang-Yang Fu², Xiao-Nian Li², Han-Dong Sun², Hong-Ping He¹, Pema-Tenzin Puno²

1. College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal Utilization, Yunnan University of Chinese Medicine, Kunming, 650500, People's Republic of China;
2. Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China

Received:2024-06-03 Online:2024-10-14 Published:2024-10-24
Contact: Hong-Ping He,E-mail:95431111@qq.com;Pema-Tenzin Puno,E-mail:punopematenzin@mail.kib.ac.cn
Supported by:
This work was financially supported by the National Science Fund for Distinguished Young Scholars (82325047), Second Tibetan Plateau Scientific Expedition and Research (STEP) program (2019QZKK0502), NSFC-Joint Foundation of Yunnan Province (U2002221), and Youth Innovation Promotion Association CAS (2023409).

Silvaticusins A-D: ent-kaurane diterpenoids and a cyclobutane-containing ent-kaurane dimer from Isodon silvaticus

Qi-Xiu Hai^1,2, Kun Hu², Su-Ping Chen², Yang-Yang Fu², Xiao-Nian Li², Han-Dong Sun², Hong-Ping He¹, Pema-Tenzin Puno²

1. College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal Utilization, Yunnan University of Chinese Medicine, Kunming, 650500, People's Republic of China;
2. Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China

通讯作者: Hong-Ping He,E-mail:95431111@qq.com;Pema-Tenzin Puno,E-mail:punopematenzin@mail.kib.ac.cn
基金资助:
This work was financially supported by the National Science Fund for Distinguished Young Scholars (82325047), Second Tibetan Plateau Scientific Expedition and Research (STEP) program (2019QZKK0502), NSFC-Joint Foundation of Yunnan Province (U2002221), and Youth Innovation Promotion Association CAS (2023409).

Abstract

Abstract: Three new ent-kaurane diterpenoids, silvaticusins A-C (1-3), along with a new ent-kaurane dimer silvaticusin D (4) were isolated from the aerial parts of Isodon silvaticus. The structures of these new compounds were established mainly by comprehensive analysis of their NMR and MS data. The absolute configuration of compounds 1 and 4 were determined using a single-crystal X-ray diffraction and computational methods, respectively. Compounds 2 and 3 were found to exhibit remarkable cytotoxic effects against five human tumor cell lines (HL-60, A-549, SMMC-7721, MDA-MB-231, and SW-480), with IC₅₀ values spanning from 1.27±0.08 to 7.52±0.33 μM.

Key words: Isodon silvaticus, ent-Kaurane diterpenoid, ent-Kaurane dimer, Cyclobutane moiety, Cytotoxicity

摘要： Three new ent-kaurane diterpenoids, silvaticusins A-C (1-3), along with a new ent-kaurane dimer silvaticusin D (4) were isolated from the aerial parts of Isodon silvaticus. The structures of these new compounds were established mainly by comprehensive analysis of their NMR and MS data. The absolute configuration of compounds 1 and 4 were determined using a single-crystal X-ray diffraction and computational methods, respectively. Compounds 2 and 3 were found to exhibit remarkable cytotoxic effects against five human tumor cell lines (HL-60, A-549, SMMC-7721, MDA-MB-231, and SW-480), with IC₅₀ values spanning from 1.27±0.08 to 7.52±0.33 μM.

关键词: Isodon silvaticus, ent-Kaurane diterpenoid, ent-Kaurane dimer, Cyclobutane moiety, Cytotoxicity

Qi-Xiu Hai, Kun Hu, Su-Ping Chen, Yang-Yang Fu, Xiao-Nian Li, Han-Dong Sun, Hong-Ping He, Pema-Tenzin Puno. Silvaticusins A-D: ent-kaurane diterpenoids and a cyclobutane-containing ent-kaurane dimer from Isodon silvaticus[J]. Natural Products and Bioprospecting, 2024, 14(5): 45-45.

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Silvaticusins A-D: ent-kaurane diterpenoids and a cyclobutane-containing ent-kaurane dimer from Isodon silvaticus

Silvaticusins A-D: ent-kaurane diterpenoids and a cyclobutane-containing ent-kaurane dimer from Isodon silvaticus

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