Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccinea

doi:10.1007/s13659-023-00376-1

Natural Products and Bioprospecting ›› 2023, Vol. 13 ›› Issue (2): 12-12.DOI: 10.1007/s13659-023-00376-1

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Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccinea

Qi-Qi Zhang^1,2, Kun Hu¹, Han-Dong Sun¹, Pema-Tenzin Puno¹

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, People's Republic of China;
2. University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China

Received:2023-03-15 Online:2023-05-18 Published:2023-04-24
Contact: Pema-Tenzin Puno,E-mail:punopematenzin@mail.kib.ac.cn
Supported by:
We thank Service Center for Bioactivity Screening, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany for bioactivity screening. This project was supported financially by the Natural Science Foundation of Yunnan Province (No. 202101AT070188).

Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccinea

Qi-Qi Zhang^1,2, Kun Hu¹, Han-Dong Sun¹, Pema-Tenzin Puno¹

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, People's Republic of China;
2. University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China

通讯作者: Pema-Tenzin Puno,E-mail:punopematenzin@mail.kib.ac.cn
基金资助:
We thank Service Center for Bioactivity Screening, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany for bioactivity screening. This project was supported financially by the Natural Science Foundation of Yunnan Province (No. 202101AT070188).

Abstract

Abstract: Four new 14(13 → 12)-abeolanostane triterpenoids featuring extended π-conjugated systems, kadcoccitanes E-H (1-4), were obtained from the stems of Kadsura coccinea through using a HPLC - UV-guided approach. Their structural and configurational determination was accomplished through extensive spectroscopic analysis coupled with quantum chemical calculations. Kadcoccitanes E-H were tested for their cytotoxic activities against five human tumor cell lines (HL-60, A-549, SMMC-7721, MDA-MB-231, SW-480) but none of them exhibited activities at the concentration 40 μM.

Key words: Kadsura coccinea, Lanostane triterpenoids, Extended π-conjugated systems, Quantum chemical calculation

摘要： Four new 14(13 → 12)-abeolanostane triterpenoids featuring extended π-conjugated systems, kadcoccitanes E-H (1-4), were obtained from the stems of Kadsura coccinea through using a HPLC - UV-guided approach. Their structural and configurational determination was accomplished through extensive spectroscopic analysis coupled with quantum chemical calculations. Kadcoccitanes E-H were tested for their cytotoxic activities against five human tumor cell lines (HL-60, A-549, SMMC-7721, MDA-MB-231, SW-480) but none of them exhibited activities at the concentration 40 μM.

关键词: Kadsura coccinea, Lanostane triterpenoids, Extended π-conjugated systems, Quantum chemical calculation

Qi-Qi Zhang, Kun Hu, Han-Dong Sun, Pema-Tenzin Puno. Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccinea[J]. Natural Products and Bioprospecting, 2023, 13(2): 12-12.

Qi-Qi Zhang, Kun Hu, Han-Dong Sun, Pema-Tenzin Puno. Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccinea[J]. 应用天然产物, 2023, 13(2): 12-12.

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Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccinea

Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccinea

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