Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculata

doi:10.1007/s13659-022-00342-3

Natural Products and Bioprospecting ›› 2022, Vol. 12 ›› Issue (3): 19-19.DOI: 10.1007/s13659-022-00342-3

• ORIGINAL ARTICLE • Previous Articles Next Articles

Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculata

Shui-Mei Zhang^1,2, Kun Hu¹, Xiao-Nian Li¹, Han-Dong Sun¹, Pema-Tenzin Puno¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing, 10039, People's Republic of China

Received:2022-03-18 Online:2022-06-24 Published:2022-06-24
Contact: Kun Hu,E-mail:hukun@mail.kib.ac.cn;Pema-Tenzin Puno,E-mail:punopematenzin@mail.kib.ac.cn
Supported by:
We thank Service Center for Bioactivity Screening, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany for bioactivity screening. This project was supported financially by the National Natural Science Foundation of China (No. 81903520).

Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculata

Shui-Mei Zhang^1,2, Kun Hu¹, Xiao-Nian Li¹, Han-Dong Sun¹, Pema-Tenzin Puno¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing, 10039, People's Republic of China

通讯作者: Kun Hu,E-mail:hukun@mail.kib.ac.cn;Pema-Tenzin Puno,E-mail:punopematenzin@mail.kib.ac.cn
基金资助:
We thank Service Center for Bioactivity Screening, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany for bioactivity screening. This project was supported financially by the National Natural Science Foundation of China (No. 81903520).

Abstract

Abstract: A pair of new tetrahydrofuran lignan enantiomers, (±)-schibiculatin A [(±)-1], a new enedione lignan, schibiculatin B (2), two new cadinane-type sesquiterpenoids, schibiculatins C (3) and D (4), along with two known seco-cadinane-type sesquiterpenoids (5 and 6) and seven known miscellaneous lignans (7–13) were isolated from the stems of Schisandra bicolor var. tuberculata. The structures of 1–4 were elucidated by comprehensive analysis of their spectroscopic data, quantum chemical calculations, as well as single-crystal X-ray diffraction. A few isolated compounds were tested for their protective activities against corticosterone-induced apoptosis in PC12 cells. Among them, compounds 5 and 6 showed moderate activities.

Key words: Schisandra bicolor var. tuberculata, Cadinane-type sesquiterpenoids, Lignans, Quantum chemical calculation

摘要： A pair of new tetrahydrofuran lignan enantiomers, (±)-schibiculatin A [(±)-1], a new enedione lignan, schibiculatin B (2), two new cadinane-type sesquiterpenoids, schibiculatins C (3) and D (4), along with two known seco-cadinane-type sesquiterpenoids (5 and 6) and seven known miscellaneous lignans (7–13) were isolated from the stems of Schisandra bicolor var. tuberculata. The structures of 1–4 were elucidated by comprehensive analysis of their spectroscopic data, quantum chemical calculations, as well as single-crystal X-ray diffraction. A few isolated compounds were tested for their protective activities against corticosterone-induced apoptosis in PC12 cells. Among them, compounds 5 and 6 showed moderate activities.

关键词: Schisandra bicolor var. tuberculata, Cadinane-type sesquiterpenoids, Lignans, Quantum chemical calculation

Shui-Mei Zhang, Kun Hu, Xiao-Nian Li, Han-Dong Sun, Pema-Tenzin Puno. Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculata[J]. Natural Products and Bioprospecting, 2022, 12(3): 19-19.

Shui-Mei Zhang, Kun Hu, Xiao-Nian Li, Han-Dong Sun, Pema-Tenzin Puno. Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculata[J]. 应用天然产物, 2022, 12(3): 19-19.

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Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculata

Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculata

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