Ypsilandrosides U-Y, five new steroidal saponins from Ypsilandra thibetica

doi:10.1007/s13659-022-00337-0

Natural Products and Bioprospecting ›› 2022, Vol. 12 ›› Issue (3): 17-17.DOI: 10.1007/s13659-022-00337-0

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Ypsilandrosides U-Y, five new steroidal saponins from Ypsilandra thibetica

Wen-Tao Gao^1,2, Ling-Ling Yu^2,3, Jing Xie^2,3, Long-Gao Xiao^2,3, Shi-Juan Zhang^2,3, Wen-Yi Ma^2,3, Huan Yan², Hai-Yang Liu²

1 College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, 650500, China;
2 State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China;
3 University of Chinese Academy of Sciences, Beijing, 100049, China

Received:2022-02-21 Online:2022-06-24 Published:2022-06-24
Contact: Hai-Yang Liu,E-mail:haiyangliu@mail.kib.ac.cn
Supported by:
This work was financially supported by the National Natural Science Foundation of China (U1802287 and 32000280), the Ten Thousand Talents Plan of Yunnan Province for Industrial Technology Leading Talents, and the State Key Laboratory of Phytochemistry and Plant Resources in West China (P2019-ZZ02).

Ypsilandrosides U-Y, five new steroidal saponins from Ypsilandra thibetica

Wen-Tao Gao^1,2, Ling-Ling Yu^2,3, Jing Xie^2,3, Long-Gao Xiao^2,3, Shi-Juan Zhang^2,3, Wen-Yi Ma^2,3, Huan Yan², Hai-Yang Liu²

1 College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, 650500, China;
2 State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China;
3 University of Chinese Academy of Sciences, Beijing, 100049, China

通讯作者: Hai-Yang Liu,E-mail:haiyangliu@mail.kib.ac.cn
基金资助:
This work was financially supported by the National Natural Science Foundation of China (U1802287 and 32000280), the Ten Thousand Talents Plan of Yunnan Province for Industrial Technology Leading Talents, and the State Key Laboratory of Phytochemistry and Plant Resources in West China (P2019-ZZ02).

Abstract

Abstract: Phytochemical reinvestigation on the whole plants of Ypsilandra thibetica obtained four new spirostanol glycosides, named ypsilandrosides U-X (1–4), and one new cholestanol glycoside, named ypsilandroside Y (5). Their structures have been established by extensive spectroscopic data and chemical methods. Among them, compound 4 is a rare spirostanol glycoside which possesses a novel 5(6 → 7) abeo-steroidal aglycone, while compound 1 is a first spirostanol bisdesmoside attached to C-3 and C-12, respectively, isolated from the genus Ypsilandra. The induced platelet aggregation activity of the isolates was tested.

Key words: Ypsilandra thibetica, Melanthiaceae, Ypsilandrosides U-Y, Spirostanol saponins, Cholestanol saponins

摘要： Phytochemical reinvestigation on the whole plants of Ypsilandra thibetica obtained four new spirostanol glycosides, named ypsilandrosides U-X (1–4), and one new cholestanol glycoside, named ypsilandroside Y (5). Their structures have been established by extensive spectroscopic data and chemical methods. Among them, compound 4 is a rare spirostanol glycoside which possesses a novel 5(6 → 7) abeo-steroidal aglycone, while compound 1 is a first spirostanol bisdesmoside attached to C-3 and C-12, respectively, isolated from the genus Ypsilandra. The induced platelet aggregation activity of the isolates was tested.

关键词: Ypsilandra thibetica, Melanthiaceae, Ypsilandrosides U-Y, Spirostanol saponins, Cholestanol saponins

Wen-Tao Gao, Ling-Ling Yu, Jing Xie, Long-Gao Xiao, Shi-Juan Zhang, Wen-Yi Ma, Huan Yan, Hai-Yang Liu. Ypsilandrosides U-Y, five new steroidal saponins from Ypsilandra thibetica[J]. Natural Products and Bioprospecting, 2022, 12(3): 17-17.

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[1]	Ling-Yu Jin, Ting-Xiang Lu,. Xu-Jie Qin, Wei Ni, Huan Yan, Yu Chen, Hui Liu, Hong-Ping He, Hai-Yang Liu. Two New Highly Oxygenated Spirostanol Saponins from Paris polyphylla var. stenophylla [J]. Natural Products and Bioprospecting, 2016, 6(4): 205-210.
[2]	Yong-Ai Si, Huan Yan, Wei Ni, Zhen-Hua Liu, Ting-Xiang Lu, Chang-Xiang Cheng, Hai-Yang Liu. Two New Steroidal Saponins from Ypsilandra thibetica [J]. Natural Products and Bioprospecting, 2014, 4(6): 315-318.
[3]	Hai-Yang LIU, Chang-Xiang CHEN, Yi LU, Jun-Yun YANG, Wei NI. Steroidal and pregnane glycosides from Ypsilandra thibetica [J]. Natural Products and Bioprospecting, 2012, 2(1): 11-15.

Ypsilandrosides U-Y, five new steroidal saponins from Ypsilandra thibetica

Ypsilandrosides U-Y, five new steroidal saponins from Ypsilandra thibetica

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