Integrative Biology Journals
Natural Products and Bioprospecting

Natural Products and Bioprospecting ›› 2014, Vol. 4 ›› Issue (6): 315-318.DOI: 10.1007/s13659-014-0043-1

• Original article •     Next Articles

Two New Steroidal Saponins from Ypsilandra thibetica

Yong-Ai Si1,2, Huan Yan1, Wei Ni1, Zhen-Hua Liu1,2, Ting-Xiang Lu1, Chang-Xiang Cheng1, Hai-Yang Liu1   

  1. 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
    2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
  • Received:2014-09-03 Revised:2014-10-25 Online:2018-02-11 Published:2014-12-24
  • Supported by:
    This work was financially supported by the National Natural Science Funding of China(No. 31170333) and the Natural Science Foundation of Yunnan Province(No. 2009CC019).

Two New Steroidal Saponins from Ypsilandra thibetica

Yong-Ai Si1,2, Huan Yan1, Wei Ni1, Zhen-Hua Liu1,2, Ting-Xiang Lu1, Chang-Xiang Cheng1, Hai-Yang Liu1   

  1. 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
    2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
  • 通讯作者: Hai-Yang Liu,e-mail:haiyangliu@mail.kib.ac.cn
  • 基金资助:
    This work was financially supported by the National Natural Science Funding of China(No. 31170333) and the Natural Science Foundation of Yunnan Province(No. 2009CC019).

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Abstract: Two new monosaccharide steroidal saponins, named ypsilandroside S(1) and ypsilandroside T(2), have been isolated from the whole plants of Ypsilandra thibetica. Their structures were elucidated as heloniogenin 3-O-β-D-apiofuranoside(1) and pregna 5, 16-dien-3β, 12α-diol-20-one-3-O-β-D-apiofuranoside(2) by spectroscopic techniques(1D and 2D NMR, MS). Compounds 1 and 2 were tested for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells.

Key words: Ypsilandra thibetica, Liliaceae, Ypsilandroside S, Ypsilandroside T

摘要： Two new monosaccharide steroidal saponins, named ypsilandroside S(1) and ypsilandroside T(2), have been isolated from the whole plants of Ypsilandra thibetica. Their structures were elucidated as heloniogenin 3-O-β-D-apiofuranoside(1) and pregna 5, 16-dien-3β, 12α-diol-20-one-3-O-β-D-apiofuranoside(2) by spectroscopic techniques(1D and 2D NMR, MS). Compounds 1 and 2 were tested for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells.

关键词: Ypsilandra thibetica, Liliaceae, Ypsilandroside S, Ypsilandroside T

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