Structures, Chemical Conversions, and Cytotoxicity of Tricholopardins C and D, Two Tricholoma Triterpenoids from the Wild Mushroom Tricholoma pardinum

doi:10.1007/s13659-021-00297-x

Natural Products and Bioprospecting ›› 2021, Vol. 11 ›› Issue (2): 235-241.DOI: 10.1007/s13659-021-00297-x

• ORIGINAL ARTICLES • Previous Articles

Structures, Chemical Conversions, and Cytotoxicity of Tricholopardins C and D, Two Tricholoma Triterpenoids from the Wild Mushroom Tricholoma pardinum

Chen Shi¹, Yue-Ling Peng², Juan He¹, Zheng-Hui Li¹, Ji-Kai Liu¹, Tao Feng¹

1 School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China;
2 The Third People's Hospital of Datong, Datong 037000, People's Republic of China

Received:2020-12-20 Revised:2021-01-05 Online:2021-04-07 Published:2021-04-24
Contact: Tao Feng
Supported by:
This work was financially supported by the National Natural Science Foundation of China (81872762) and the Hubei Provincial Natural Science Foundation of China (2019CFB387). The authors thank the Analytical & Measuring Center, School of Pharmaceutical Sciences, South-Central University for Nationalities for spectra test.

Structures, Chemical Conversions, and Cytotoxicity of Tricholopardins C and D, Two Tricholoma Triterpenoids from the Wild Mushroom Tricholoma pardinum

Chen Shi¹, Yue-Ling Peng², Juan He¹, Zheng-Hui Li¹, Ji-Kai Liu¹, Tao Feng¹

1 School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China;
2 The Third People's Hospital of Datong, Datong 037000, People's Republic of China

通讯作者: Tao Feng
基金资助:
This work was financially supported by the National Natural Science Foundation of China (81872762) and the Hubei Provincial Natural Science Foundation of China (2019CFB387). The authors thank the Analytical & Measuring Center, School of Pharmaceutical Sciences, South-Central University for Nationalities for spectra test.

Abstract

Abstract: Two undescribed Tricholoma triterpenoids, namely tricholopardins C (1) and D (2), were isolated from the wild mushroom Tricholoma pardinum. Their structures with absolute configurations were elucidated by spectroscopic methods, as well as the single crystal X-ray diffraction. Compounds 1 and 2 were further obtained by chemical conversions from the known analogues. Compound 1 showed significant cytotoxicity to MCF-7 and Hela cell lines with IC₅₀ values of 4.7 μM and 9.7 μM, respectively. Its mechanism of inducing MCF-7 cell apoptosis was studied briefly.

Key words: Tricholoma pardinum, Tricholoma triterpenoids, Chemical conversion, Cytotoxicity

摘要： Two undescribed Tricholoma triterpenoids, namely tricholopardins C (1) and D (2), were isolated from the wild mushroom Tricholoma pardinum. Their structures with absolute configurations were elucidated by spectroscopic methods, as well as the single crystal X-ray diffraction. Compounds 1 and 2 were further obtained by chemical conversions from the known analogues. Compound 1 showed significant cytotoxicity to MCF-7 and Hela cell lines with IC₅₀ values of 4.7 μM and 9.7 μM, respectively. Its mechanism of inducing MCF-7 cell apoptosis was studied briefly.

关键词: Tricholoma pardinum, Tricholoma triterpenoids, Chemical conversion, Cytotoxicity

Chen Shi, Yue-Ling Peng, Juan He, Zheng-Hui Li, Ji-Kai Liu, Tao Feng. Structures, Chemical Conversions, and Cytotoxicity of Tricholopardins C and D, Two Tricholoma Triterpenoids from the Wild Mushroom Tricholoma pardinum[J]. Natural Products and Bioprospecting, 2021, 11(2): 235-241.

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Structures, Chemical Conversions, and Cytotoxicity of Tricholopardins C and D, Two Tricholoma Triterpenoids from the Wild Mushroom Tricholoma pardinum

Structures, Chemical Conversions, and Cytotoxicity of Tricholopardins C and D, Two Tricholoma Triterpenoids from the Wild Mushroom Tricholoma pardinum

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