Natural Products in Cancer Therapy: Past, Present and Future

doi:10.1007/s13659-020-00293-7

Abstract

Abstract: Natural products, with remarkable chemical diversity, have been extensively investigated for their anticancer potential for more than a half-century. The collective efforts of the community have achieved the tremendous advancements, bringing natural products to clinical use and discovering new therapeutic opportunities, yet the challenges remain ahead. With remarkable changes in the landscape of cancer therapy and growing role of cutting-edge technologies, we may have come to a crossroads to revisit the strategies to understand nature products and to explore their therapeutic utility. This review summarizes the key advancements in nature product-centered cancer research and calls for the implementation of systematic approaches, new pharmacological models, and exploration of emerging directions to revitalize natural products search in cancer therapy.

Key words: Natural products, Cancer therapy, Drug discovery, Antibody-drug conjugates, Combination therapy

摘要： Natural products, with remarkable chemical diversity, have been extensively investigated for their anticancer potential for more than a half-century. The collective efforts of the community have achieved the tremendous advancements, bringing natural products to clinical use and discovering new therapeutic opportunities, yet the challenges remain ahead. With remarkable changes in the landscape of cancer therapy and growing role of cutting-edge technologies, we may have come to a crossroads to revisit the strategies to understand nature products and to explore their therapeutic utility. This review summarizes the key advancements in nature product-centered cancer research and calls for the implementation of systematic approaches, new pharmacological models, and exploration of emerging directions to revitalize natural products search in cancer therapy.

关键词: Natural products, Cancer therapy, Drug discovery, Antibody-drug conjugates, Combination therapy

Min Huang, Jin-Jian Lu, Jian Ding. Natural Products in Cancer Therapy: Past, Present and Future[J]. Natural Products and Bioprospecting, 2021, 11(1): 5-13.

Min Huang, Jin-Jian Lu, Jian Ding. Natural Products in Cancer Therapy: Past, Present and Future[J]. 应用天然产物, 2021, 11(1): 5-13.

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