Advances in chemistry and bioactivity of the genus Erythroxylum

doi:10.1007/s13659-022-00338-z

Natural Products and Bioprospecting ›› 2022, Vol. 12 ›› Issue (3): 15-15.DOI: 10.1007/s13659-022-00338-z

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Advances in chemistry and bioactivity of the genus Erythroxylum

Yulian Lv^1,2, Tian Tian^1,2, Yong-Jiang Wang^1,2, Jian-Ping Huang^1,3, Sheng-Xiong Huang¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, CAS Center for Excellence in Molecular Plant Sciences, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China;
2 University of Chinese Academy of Sciences, Beijing, 100049, China;
3 State Key Laboratory of Southwestern Chinese Medicine Resources, Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China

Received:2022-01-03 Online:2022-06-24 Published:2022-06-24
Contact: Sheng-Xiong Huang,E-mail:sxhuang@mail.kib.ac.cn
Supported by:
This research was supported by the National Key R&D Program of China (2018YFA0900600), the National Science Foundation of China (U1902212 and 32000239), the Foundations of Yunnan Province (2019FJ007 and 2019ZF011–2), the Strategic Priority Research Program of the CAS (XDB27020205), and the Key Research Program of Frontier Sciences of the CAS (QYZDB-SSW-SMC051).

Advances in chemistry and bioactivity of the genus Erythroxylum

Yulian Lv^1,2, Tian Tian^1,2, Yong-Jiang Wang^1,2, Jian-Ping Huang^1,3, Sheng-Xiong Huang¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, CAS Center for Excellence in Molecular Plant Sciences, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China;
2 University of Chinese Academy of Sciences, Beijing, 100049, China;
3 State Key Laboratory of Southwestern Chinese Medicine Resources, Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China

通讯作者: Sheng-Xiong Huang,E-mail:sxhuang@mail.kib.ac.cn
基金资助:
This research was supported by the National Key R&D Program of China (2018YFA0900600), the National Science Foundation of China (U1902212 and 32000239), the Foundations of Yunnan Province (2019FJ007 and 2019ZF011–2), the Strategic Priority Research Program of the CAS (XDB27020205), and the Key Research Program of Frontier Sciences of the CAS (QYZDB-SSW-SMC051).

Abstract

Abstract: Erythroxylum P. Browne is the largest and most representative genus of Erythroxylaceae family. It contains approximately 230 species that are mainly distributed in tropical and subtropical regions. Some species in this genus, such as E. monogynum and E. coca, have been used as folk medicines in India or South America for a long history. It is well known that Erythroxylum plants are rich in tropane alkaloids, and the representative member cocaine shows remarkable activity in human central nervous system. However, many other types of active compounds have also been found in Erythroxylum along with the broadening and deepening of phytochemical research. To date, a total of 383 compounds from Erythroxylum have been reported, among which only 186 tropane alkaloids have been reviewed in 2010. In this review, we summarized all remained 197 compounds characterized from 53 Erythroxylum species from 1960 to 2021, which include diterpenes, triterpenes, alkaloids, flavonoids, and other derivates, providing a comprehensive overview of phytoconstituents profile of Erythroxylum plants. In addition, the biological activities of representative phytochemicals and crude extracts were also highlighted.

Key words: Erythroxylum, Natural products, Phytoconstituent, Bioactivity

摘要： Erythroxylum P. Browne is the largest and most representative genus of Erythroxylaceae family. It contains approximately 230 species that are mainly distributed in tropical and subtropical regions. Some species in this genus, such as E. monogynum and E. coca, have been used as folk medicines in India or South America for a long history. It is well known that Erythroxylum plants are rich in tropane alkaloids, and the representative member cocaine shows remarkable activity in human central nervous system. However, many other types of active compounds have also been found in Erythroxylum along with the broadening and deepening of phytochemical research. To date, a total of 383 compounds from Erythroxylum have been reported, among which only 186 tropane alkaloids have been reviewed in 2010. In this review, we summarized all remained 197 compounds characterized from 53 Erythroxylum species from 1960 to 2021, which include diterpenes, triterpenes, alkaloids, flavonoids, and other derivates, providing a comprehensive overview of phytoconstituents profile of Erythroxylum plants. In addition, the biological activities of representative phytochemicals and crude extracts were also highlighted.

关键词: Erythroxylum, Natural products, Phytoconstituent, Bioactivity

Yulian Lv, Tian Tian, Yong-Jiang Wang, Jian-Ping Huang, Sheng-Xiong Huang. Advances in chemistry and bioactivity of the genus Erythroxylum[J]. Natural Products and Bioprospecting, 2022, 12(3): 15-15.

Yulian Lv, Tian Tian, Yong-Jiang Wang, Jian-Ping Huang, Sheng-Xiong Huang. Advances in chemistry and bioactivity of the genus Erythroxylum[J]. 应用天然产物, 2022, 12(3): 15-15.

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Advances in chemistry and bioactivity of the genus Erythroxylum

Advances in chemistry and bioactivity of the genus Erythroxylum

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