New benzene derivatives from cultures of ascomycete Daldinia concentrica

doi:10.1007/s13659-013-0048-1

Natural Products and Bioprospecting ›› 2013, Vol. 3 ›› Issue (4): 150-153.DOI: 10.1007/s13659-013-0048-1

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New benzene derivatives from cultures of ascomycete Daldinia concentrica

Tao FENG^a, Zheng-Hui LI^a, Xia YIN^a,b, Ze-Jun DONG^a, Gang-Qiang WANG^c, Xing-Yao LI^a, Yan LI^a, Ji-Kai LIU^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b University of Chinese Academy of Sciences, Beijing 100049, China;
c School of Chemistry and Chemical Engineering of Hunan University, Changsha 410082, China

Received:2013-07-04 Revised:2013-08-01 Online:2018-02-11 Published:2013-08-24
Supported by:
This project was supported by the National Basic Research Program of China (973 Program, 2009CB522300), the National Natural Sciences Foundation of China (30830113, 81102346), and Youth Innovation Promotion Association CAS.

New benzene derivatives from cultures of ascomycete Daldinia concentrica

Tao FENG^a, Zheng-Hui LI^a, Xia YIN^a,b, Ze-Jun DONG^a, Gang-Qiang WANG^c, Xing-Yao LI^a, Yan LI^a, Ji-Kai LIU^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b University of Chinese Academy of Sciences, Beijing 100049, China;
c School of Chemistry and Chemical Engineering of Hunan University, Changsha 410082, China

通讯作者: Ji-Kai LIU,E-mail:jkliu@mail.kib.ac.cn
基金资助:
This project was supported by the National Basic Research Program of China (973 Program, 2009CB522300), the National Natural Sciences Foundation of China (30830113, 81102346), and Youth Innovation Promotion Association CAS.

Abstract

Abstract: Three new benzene derivatives, named daldins A-C (1-3), together with a known analogue, 2-hydroxymethyl-3-(1-hydroxypropyl) phenol (4) have been isolated from cultures of ascomycete Daldinia concentrica. The structures of 1-4 with absolute configuration were established by means of spectroscopic methods and X-ray diffraction. All compounds showed no significant inhibition on five human cancer cell lines with IC₅₀ values > 40 μmol.

Key words: Daldinia concentrica, benzene derivatives, absolute configuration

摘要： Three new benzene derivatives, named daldins A-C (1-3), together with a known analogue, 2-hydroxymethyl-3-(1-hydroxypropyl) phenol (4) have been isolated from cultures of ascomycete Daldinia concentrica. The structures of 1-4 with absolute configuration were established by means of spectroscopic methods and X-ray diffraction. All compounds showed no significant inhibition on five human cancer cell lines with IC₅₀ values > 40 μmol.

关键词: Daldinia concentrica, benzene derivatives, absolute configuration

Tao FENG, Zheng-Hui LI, Xia YIN, Ze-Jun DONG, Gang-Qiang WANG, Xing-Yao LI, Yan LI, Ji-Kai LIU. New benzene derivatives from cultures of ascomycete Daldinia concentrica[J]. Natural Products and Bioprospecting, 2013, 3(4): 150-153.

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New benzene derivatives from cultures of ascomycete Daldinia concentrica

New benzene derivatives from cultures of ascomycete Daldinia concentrica

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