Review on “Long-Dan”, one of the traditional Chinese medicinal herbs recorded in Chinese Pharmacopoeia

doi:10.1007/s13659-011-0043-3

Natural Products and Bioprospecting ›› 2012, Vol. 2 ›› Issue (1): 1-10.DOI: 10.1007/s13659-011-0043-3

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Review on “Long-Dan”, one of the traditional Chinese medicinal herbs recorded in Chinese Pharmacopoeia

Yan-Ming WANG^a,b, Min XU^a, Dong WANG^a, Hong-Tao ZHU^a, Chong-Ren YANG^a,c, Ying-Jun ZHANG^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
b Graduate University of Chinese Academy of Sciences, Beijing 100049, China
c Weihe Biotech Laboratory, Yuxi 653100, China

Received:2011-12-03 Revised:2012-02-05 Online:2018-02-11 Published:2012-02-24
Supported by:
This work was supported by Science and Technology Planning Project of Yunnan Province(2010CD106), the 973 Program of Ministry of Science and Technology of China(2011CB915503). the State Key Laboratory of Phytochemistry and Plant Resources in West China, Chinese Academy of Sciences(P2010-ZZ03) and The Fourteenth Candidates of the Young Academic Leaders of Yunnan Province(Min XU, 2011CI044).

Review on “Long-Dan”, one of the traditional Chinese medicinal herbs recorded in Chinese Pharmacopoeia

Yan-Ming WANG^a,b, Min XU^a, Dong WANG^a, Hong-Tao ZHU^a, Chong-Ren YANG^a,c, Ying-Jun ZHANG^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
b Graduate University of Chinese Academy of Sciences, Beijing 100049, China
c Weihe Biotech Laboratory, Yuxi 653100, China

通讯作者: Min XU,E-mail:xumin@mail.kib.ac.cn;Ying-Jun ZHANG,E-mail:zhangyj@mail.kib.ac.cn
基金资助:
This work was supported by Science and Technology Planning Project of Yunnan Province(2010CD106), the 973 Program of Ministry of Science and Technology of China(2011CB915503). the State Key Laboratory of Phytochemistry and Plant Resources in West China, Chinese Academy of Sciences(P2010-ZZ03) and The Fourteenth Candidates of the Young Academic Leaders of Yunnan Province(Min XU, 2011CI044).

Abstract

Abstract: Long-Dan is an important traditional Chinese medicinal(TCM) herb used widely for the treatment of inflammation, hepatitis, rheumatism, cholecystitis, and tuberculosis. In the Chinese Pharmacopoeia, the roots and rhizomes of four species from the genus Gentiana(Gentianaceae) are recorded as the original materials of "Long-Dan", called Gentianae Radix et Rhizoma. The species included G. manshurica, G. scabra, G. triflora and G. rigescens, which are distributed in different areas of China. Though iridoid and secoiridoid glucosides were reported as the main constituents in "Long-Dan", these four different species also resulted in different minor components, which may related to their pharmacological activities. Herein, we summarized the herbal textual study, distribution, chemical constituents, biological investigation and quality control of the recorded "Long-Dan" origins in Chinese Pharmacopoeia during the period 1960 to 2011.

Key words: Long-Dan, Chinese Pharmacopoeia, herbal textual study, chemistry, bioactivity, quality control

摘要： Long-Dan is an important traditional Chinese medicinal(TCM) herb used widely for the treatment of inflammation, hepatitis, rheumatism, cholecystitis, and tuberculosis. In the Chinese Pharmacopoeia, the roots and rhizomes of four species from the genus Gentiana(Gentianaceae) are recorded as the original materials of "Long-Dan", called Gentianae Radix et Rhizoma. The species included G. manshurica, G. scabra, G. triflora and G. rigescens, which are distributed in different areas of China. Though iridoid and secoiridoid glucosides were reported as the main constituents in "Long-Dan", these four different species also resulted in different minor components, which may related to their pharmacological activities. Herein, we summarized the herbal textual study, distribution, chemical constituents, biological investigation and quality control of the recorded "Long-Dan" origins in Chinese Pharmacopoeia during the period 1960 to 2011.

关键词: Long-Dan, Chinese Pharmacopoeia, herbal textual study, chemistry, bioactivity, quality control

Yan-Ming WANG, Min XU, Dong WANG, Hong-Tao ZHU, Chong-Ren YANG, Ying-Jun ZHANG. Review on “Long-Dan”, one of the traditional Chinese medicinal herbs recorded in Chinese Pharmacopoeia[J]. Natural Products and Bioprospecting, 2012, 2(1): 1-10.

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Review on “Long-Dan”, one of the traditional Chinese medicinal herbs recorded in Chinese Pharmacopoeia

Review on “Long-Dan”, one of the traditional Chinese medicinal herbs recorded in Chinese Pharmacopoeia

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