Euglobal-IIIa, a novel acylphloroglucinol-sesquiterpene derivative from Eucalyptus robusta: absolute structure and cytotoxicity

doi:10.1007/s13659-011-0021-9

Natural Products and Bioprospecting ›› 2011, Vol. 1 ›› Issue (2): 101-103.DOI: 10.1007/s13659-011-0021-9

• Short Communication • Previous Articles

Euglobal-IIIa, a novel acylphloroglucinol-sesquiterpene derivative from Eucalyptus robusta: absolute structure and cytotoxicity

Li-Yan PENG, Juan HE, Gang XU, Xing-De WU, Liao-Bin DONG, Xiu GAO, Xiao CHENG, Jia SU, Yan LI, Qin-Shi ZHAO

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China

Received:2011-09-25 Revised:2011-10-11 Online:2017-11-24 Published:2011-04-24
Supported by:
This work was financially supported by the National Natural Science Foundation of China(No. 90813004 and No. 2009312311024), the 973 Program(No. 2009CB522300), and the State Key Laboratory of Phytochemistry and Plant Resources in West China(P2010-ZZ05).

Euglobal-IIIa, a novel acylphloroglucinol-sesquiterpene derivative from Eucalyptus robusta: absolute structure and cytotoxicity

Li-Yan PENG, Juan HE, Gang XU, Xing-De WU, Liao-Bin DONG, Xiu GAO, Xiao CHENG, Jia SU, Yan LI, Qin-Shi ZHAO

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China

通讯作者: Qin-Shi ZHAO,E-mail:qinshizhao@mail.kib.ac.cn
基金资助:
This work was financially supported by the National Natural Science Foundation of China(No. 90813004 and No. 2009312311024), the 973 Program(No. 2009CB522300), and the State Key Laboratory of Phytochemistry and Plant Resources in West China(P2010-ZZ05).

Abstract

Abstract: Euglobal-IIIa(1), a novel acylphloroglucinol-sesquiterpene derivative, and a known analogue, have been isolated from leaves of Eucalyptus robusta. The structures was elucidated by extensive spectroscopic data and by comparison with data reported in literature, while the absolute configuration of 1 was determined by the X-ray diffraction analysis. Compound 1 exhibited comparable cytotoxicity with that of cisplatin against five human cancer cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480 with IC₅₀ values of 15.7, 15.5, 17.6, 14.3, and 21.8 μM, respectively.

Key words: Eucalyptus robusta, acylphloroglucinol-sesquiterpene, absolute structure, cytotoxicity

摘要： Euglobal-IIIa(1), a novel acylphloroglucinol-sesquiterpene derivative, and a known analogue, have been isolated from leaves of Eucalyptus robusta. The structures was elucidated by extensive spectroscopic data and by comparison with data reported in literature, while the absolute configuration of 1 was determined by the X-ray diffraction analysis. Compound 1 exhibited comparable cytotoxicity with that of cisplatin against five human cancer cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480 with IC₅₀ values of 15.7, 15.5, 17.6, 14.3, and 21.8 μM, respectively.

关键词: Eucalyptus robusta, acylphloroglucinol-sesquiterpene, absolute structure, cytotoxicity

Li-Yan PENG, Juan HE, Gang XU, Xing-De WU, Liao-Bin DONG, Xiu GAO, Xiao CHENG, Jia SU, Yan LI, Qin-Shi ZHAO. Euglobal-IIIa, a novel acylphloroglucinol-sesquiterpene derivative from Eucalyptus robusta: absolute structure and cytotoxicity[J]. Natural Products and Bioprospecting, 2011, 1(2): 101-103.

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Euglobal-IIIa, a novel acylphloroglucinol-sesquiterpene derivative from Eucalyptus robusta: absolute structure and cytotoxicity

Euglobal-IIIa, a novel acylphloroglucinol-sesquiterpene derivative from Eucalyptus robusta: absolute structure and cytotoxicity

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