Integrative Biology Journals
Natural Products and Bioprospecting

Natural Products and Bioprospecting ›› 2019, Vol. 9 ›› Issue (1): 69-74.DOI: 10.1007/s13659-018-0195-5

• ORIGINAL ARTICLES • Previous Articles     Next Articles

Isolation, Structural Assignment of Isoselagintamarlin A from Selaginella tamariscina and Its Biomimetic Synthesis

Qin-Feng Zhu1,2, Li-Dong Shao1, Xing-De Wu1, Jiang-Xin Liu1, Qin-Shi Zhao1   

  1. 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
    2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China
  • Received:2018-11-06 Online:2019-01-28 Published:2019-02-24
  • Contact: Qin-Shi Zhao
  • Supported by:
    This work was financially supported by the NSFCJoint Foundation of Yunnan Province (No. U1502223), the National Natural Science Foundation of China (Nos. 21837003, 21778059 and 81773611), the Science and Technology Program of Yunnan Province (No. 2018ZF001).

Isolation, Structural Assignment of Isoselagintamarlin A from Selaginella tamariscina and Its Biomimetic Synthesis

Qin-Feng Zhu1,2, Li-Dong Shao1, Xing-De Wu1, Jiang-Xin Liu1, Qin-Shi Zhao1   

  1. 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
    2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China
  • 通讯作者: Qin-Shi Zhao
  • 基金资助:
    This work was financially supported by the NSFCJoint Foundation of Yunnan Province (No. U1502223), the National Natural Science Foundation of China (Nos. 21837003, 21778059 and 81773611), the Science and Technology Program of Yunnan Province (No. 2018ZF001).

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Abstract: Isoselagintamarlin A (1), a selaginellin analogue featured a rare benzofuran unit, was isolated from Selaginella tamariscina. Its complete structural assignment was established through a combination of high-field NMR technique and biomimetic synthesis. Notably, isoselagintamarlin A (1) was successfully synthesized via sequential oxidations and intramolecular cyclization.

Key words: Selaginella tamariscina, Selaginellin, Biomimetic synthesis, Isoselagintamarlin A

摘要： Isoselagintamarlin A (1), a selaginellin analogue featured a rare benzofuran unit, was isolated from Selaginella tamariscina. Its complete structural assignment was established through a combination of high-field NMR technique and biomimetic synthesis. Notably, isoselagintamarlin A (1) was successfully synthesized via sequential oxidations and intramolecular cyclization.

关键词: Selaginella tamariscina, Selaginellin, Biomimetic synthesis, Isoselagintamarlin A

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