Brevipedicelones D and E, Two C-O-C Flavonoid Dimmers from the Leaves of Garcinia brevipedicellata and Anti-onchocercal Activity

doi:10.1007/s13659-018-0191-9

Natural Products and Bioprospecting ›› 2019, Vol. 9 ›› Issue (1): 61-68.DOI: 10.1007/s13659-018-0191-9

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Brevipedicelones D and E, Two C-O-C Flavonoid Dimmers from the Leaves of Garcinia brevipedicellata and Anti-onchocercal Activity

Mirabel Akongwi^1,2, Anastasie E. Tih¹, Kennedy D. Nyongbela², Moses Samje³, Raphael T. Ghogomu¹, Bernard Bodo⁴

1 Department of Organic Chemistry, Faculty of Science, University of Yaounde 1, P. O. Box 812, Yaounde, Cameroon;
2 Pharmacochemistry Research Laboratory, Department of Chemistry, Faculty of Science, University of Buea, P. O. Box 63, Buea, South West Region, Cameroon;
3 Faculty of Science, ANDI Centre of Excellence on Onchocerciasis Research, University of Buea, P. O. Box 63, Buea, South West Region, Cameroon;
4 Laboratoire de Chimie des Substances Naturelles, Muséum National d'Histoire Naturelle, 63 Rue Buffon, 75005 Paris, France

Received:2018-07-04 Online:2019-01-28 Published:2019-02-24
Contact: Mirabel Akongwi

Brevipedicelones D and E, Two C-O-C Flavonoid Dimmers from the Leaves of Garcinia brevipedicellata and Anti-onchocercal Activity

Mirabel Akongwi^1,2, Anastasie E. Tih¹, Kennedy D. Nyongbela², Moses Samje³, Raphael T. Ghogomu¹, Bernard Bodo⁴

1 Department of Organic Chemistry, Faculty of Science, University of Yaounde 1, P. O. Box 812, Yaounde, Cameroon;
2 Pharmacochemistry Research Laboratory, Department of Chemistry, Faculty of Science, University of Buea, P. O. Box 63, Buea, South West Region, Cameroon;
3 Faculty of Science, ANDI Centre of Excellence on Onchocerciasis Research, University of Buea, P. O. Box 63, Buea, South West Region, Cameroon;
4 Laboratoire de Chimie des Substances Naturelles, Muséum National d'Histoire Naturelle, 63 Rue Buffon, 75005 Paris, France

通讯作者: Mirabel Akongwi

Abstract

Abstract: A novel isoflavone-chromone flavonoid C-O-C dimmer, brevipedicelone D (1), along with one new C-O-C biflavonoid derivative, brevipedicelone E (2), were isolated from the ethyl acetate extract of the leaves of Garcinia brevipedicellata, a medicinal plant used in folk medicine in parts of Cameroon. Their structures were elucidated by extensive spectroscopic techniques, including 1D- and 2D- NMR, MS experiments, as well as comparing their spectral data with those of known analogues. Anti-onchocercal screening of 1 showed moderate inhibition of adult worm motility of Onchocerca ochengi by 60% at the highest concentration (20 μg/mL) and inhibited motility of both the juvenile worms of O. ochengi and Loa loa by 90% at this same concentration.

Key words: Garcinia brevipedicellata, Brevipedicelone, Anti-onchocercal activity

摘要： A novel isoflavone-chromone flavonoid C-O-C dimmer, brevipedicelone D (1), along with one new C-O-C biflavonoid derivative, brevipedicelone E (2), were isolated from the ethyl acetate extract of the leaves of Garcinia brevipedicellata, a medicinal plant used in folk medicine in parts of Cameroon. Their structures were elucidated by extensive spectroscopic techniques, including 1D- and 2D- NMR, MS experiments, as well as comparing their spectral data with those of known analogues. Anti-onchocercal screening of 1 showed moderate inhibition of adult worm motility of Onchocerca ochengi by 60% at the highest concentration (20 μg/mL) and inhibited motility of both the juvenile worms of O. ochengi and Loa loa by 90% at this same concentration.

关键词: Garcinia brevipedicellata, Brevipedicelone, Anti-onchocercal activity

Mirabel Akongwi, Anastasie E. Tih, Kennedy D. Nyongbela, Moses Samje, Raphael T. Ghogomu, Bernard Bodo. Brevipedicelones D and E, Two C-O-C Flavonoid Dimmers from the Leaves of Garcinia brevipedicellata and Anti-onchocercal Activity[J]. Natural Products and Bioprospecting, 2019, 9(1): 61-68.

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Brevipedicelones D and E, Two C-O-C Flavonoid Dimmers from the Leaves of Garcinia brevipedicellata and Anti-onchocercal Activity

Brevipedicelones D and E, Two C-O-C Flavonoid Dimmers from the Leaves of Garcinia brevipedicellata and Anti-onchocercal Activity

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