Pharmacological and Predicted Activities of Natural Azo Compounds

doi:10.1007/s13659-016-0117-3

Abstract

Abstract: This paper describes research on natural azo compounds isolated from fungi, plant, bacteria, and invertebrates. More than 120 biologically active diazene containing alkaloids demonstrate confirmed pharmacological activity, including antitumor, antimicrobial, and antibacterial effects. The structures, origin, and biological activities of azo compounds are reviewed. Utilizing the computer program PASS, some structure-activity relationship new activities are also predicted, pointing toward possible new applications of these compounds. This article emphasizes the role of natural azo compounds as an important source of drug prototypes and leads for drug discovery.

Key words: Azo metabolites, Alkaloids, Fungi, Plant, Bacteria, Sponges, SAR

摘要： This paper describes research on natural azo compounds isolated from fungi, plant, bacteria, and invertebrates. More than 120 biologically active diazene containing alkaloids demonstrate confirmed pharmacological activity, including antitumor, antimicrobial, and antibacterial effects. The structures, origin, and biological activities of azo compounds are reviewed. Utilizing the computer program PASS, some structure-activity relationship new activities are also predicted, pointing toward possible new applications of these compounds. This article emphasizes the role of natural azo compounds as an important source of drug prototypes and leads for drug discovery.

关键词: Azo metabolites, Alkaloids, Fungi, Plant, Bacteria, Sponges, SAR

Valery M. Dembitsky, Tatyana A. Gloriozova, Vladimir V. Poroikov. Pharmacological and Predicted Activities of Natural Azo Compounds[J]. Natural Products and Bioprospecting, 2017, 7(1): 151-169.

Valery M. Dembitsky, Tatyana A. Gloriozova, Vladimir V. Poroikov. Pharmacological and Predicted Activities of Natural Azo Compounds[J]. 应用天然产物, 2017, 7(1): 151-169.

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