Abstract: Two new steroids, 3α, 17α, 19, 20-tetrahydroxy-4α-methylpregn-8-ene(1) and 3α, 12α, 17α, 20-tetrahydroxy-4α-methylpregn-8-ene(2) and three new sesquiterpenoids, 12-hydroxy-α-cadinol(3), 3α, 12-dihydroxy-δ-cadinol(4), and 3α, 6α-dihydroxyspiroax-4-ene(5), have been isolated from cultures of the fungus Phellinus igniarius. Their structures were characterized based on extensive spectroscopic data. In preliminary in vitro assays, compounds 3 and 4 exhibited the vascular-activities against phenylephrine-induced vasoconstriction with the relaxing rates of 11.0% and 7.0% at 3×10^-4 M, respectively.

Key words: Pregnene steroids, Sesquiterpenes, Phellinus igniarius, Cytotoxicity, Vascular-activities

摘要： Two new steroids, 3α, 17α, 19, 20-tetrahydroxy-4α-methylpregn-8-ene(1) and 3α, 12α, 17α, 20-tetrahydroxy-4α-methylpregn-8-ene(2) and three new sesquiterpenoids, 12-hydroxy-α-cadinol(3), 3α, 12-dihydroxy-δ-cadinol(4), and 3α, 6α-dihydroxyspiroax-4-ene(5), have been isolated from cultures of the fungus Phellinus igniarius. Their structures were characterized based on extensive spectroscopic data. In preliminary in vitro assays, compounds 3 and 4 exhibited the vascular-activities against phenylephrine-induced vasoconstriction with the relaxing rates of 11.0% and 7.0% at 3×10^-4 M, respectively.

关键词: Pregnene steroids, Sesquiterpenes, Phellinus igniarius, Cytotoxicity, Vascular-activities