Treatment of Iron-Loaded Veterinary Sarcoma by Artemisia annua

doi:10.1007/s13659-014-0013-7

Abstract

Abstract: Artemisinin, a constituent of Artemisia annua L. , is a well-known antimalarial drug. Artemisinin-type drugs also inhibit cancer growth in vitro and in vivo. Herbal extracts of A. annua inhibit the growth of cancer cell lines. Here, we report on the use of capsules containing powder of Herba Artemisiae annuae to treat pet sarcoma. The surgical tumor removal as standard treatment was supplemented by adjuvant therapy with A. annua. One cat and one dog with fibrosarcoma survived 40 and 37 months, respectively, without tumor relapse. Two other dogs suffering from fibrosarcoma and hemangioendothelial sarcoma also showed complete remission and are still alive after 39 and 26 months, respectively. A. annua was well tolerated without noticeable side effects. These four cases indicate that A. annua may be a promising herbal drug for cancer therapy.

Key words: Artemisinin, Asteraceae, Scopoletin, Veterinary cancer, Comparative oncology

摘要： Artemisinin, a constituent of Artemisia annua L. , is a well-known antimalarial drug. Artemisinin-type drugs also inhibit cancer growth in vitro and in vivo. Herbal extracts of A. annua inhibit the growth of cancer cell lines. Here, we report on the use of capsules containing powder of Herba Artemisiae annuae to treat pet sarcoma. The surgical tumor removal as standard treatment was supplemented by adjuvant therapy with A. annua. One cat and one dog with fibrosarcoma survived 40 and 37 months, respectively, without tumor relapse. Two other dogs suffering from fibrosarcoma and hemangioendothelial sarcoma also showed complete remission and are still alive after 39 and 26 months, respectively. A. annua was well tolerated without noticeable side effects. These four cases indicate that A. annua may be a promising herbal drug for cancer therapy.

关键词: Artemisinin, Asteraceae, Scopoletin, Veterinary cancer, Comparative oncology

Elmar Breuer, Thomas Efferth. Treatment of Iron-Loaded Veterinary Sarcoma by Artemisia annua[J]. Natural Products and Bioprospecting, 2014, 4(2): 113-118.

Elmar Breuer, Thomas Efferth. Treatment of Iron-Loaded Veterinary Sarcoma by Artemisia annua[J]. 应用天然产物, 2014, 4(2): 113-118.

References

1. D.L. Klayman, Science 228, 1049-1055 (1985)
2. T. Efferth, Planta Med. 73, 299-309 (2007)
3. W.S. Sun, J.X. Han, W.Y. Yang, D.A. Deng, X.F. Yue, Acta Pharmacol. Sin. 13, 541-543 (1992)
4. H.J. Woerdenbag, T.A. Moskal, N. Pras, T.M. Malingre, F.S. elFeraly, H.H. Kampinga, A.W. Konings, J. Nat. Prod. 56, 845-849 (1993)
5. G.Q. Zheng, Planta Med. 60, 54-57 (1994)
6. J.C. Moore, H. Lai, J.R. Li, R.L. Ren, J.A. McDougall, N.P. Singh, C.K. Chou, Cancer Lett. 98, 83-87 (1995)
7. T. Efferth, G. Rücker, M. Falkenberg, D. Manns, A. Olbrich, U. Fabry, R. Osieka, Arzneim. Forsch. 46, 196-200 (1996)
8. T. Efferth, H. Dunstan, A. Sauerbrey, H. Miyachi, C.R. Chitambar, Int. J. Oncol. 18, 767-773 (2001)
9. T. Efferth, Drug Resist. Updat. 8, 85-97 (2005)
10. T. Efferth, Curr. Drug Targets 7, 407-421 (2006)
11. T. Efferth, M.M. Briehl, M.E. Tome, Int. J. Oncol. 23, 1231-1235 (2003)
12. T. Efferth, F. Oesch, Biochem. Pharmacol. 68, 3-10 (2004)
13. T. Efferth, A. Benakis, M.R. Romero, M. Tomicic, R. Rauh, D. Steinbach, R. Hafer, T. Stamminger, F. Oesch, B. Kaina, M. Marschall, Free Radic. Biol. Med. 37, 998-1009 (2004)
14. G. Kelter, D. Steinbach, V.B. Konkimalla, T. Tahara, S. Taketani, H.H. Fiebig, T. Efferth, PLoS One 2, e798 (2007)
15. T. Efferth, M. Volm, In Vivo. 19, 225-232 (2005)
16. P.C. Li, E. Lam, W.P. Roos, M.Z. Zdzienicka, B. Kaina, T. Efferth, Cancer Res. 68, 4347-4351 (2008)
17. N. Berdelle, T. Nikolova, S. Quiros, T. Efferth, B. Kaina, Mol. Cancer Ther. 10, 2224-2233 (2011)
18. T. Eichhorn, S. Schloissnig, B. Hahn, A. Wendler, R. Mertens, W.D. Lehmann, R.L. Krauth-Siegel, T. Efferth, Mol. BioSyst. 8, 1311-1318 (2012)
19. T. Eichhorn, D. Winter, B. Büchele, N. Dirdjaja, M. Frank, W.D. Lehmann, R. Mertens, R.L. Krauth-Siegel, T. Simmet, J. Granzin, T. Efferth, Biochem. Pharmacol. 85, 38-45 (2013)
20. L. Steinbrück, G. Pereira, T. Efferth, Cancer Genomics Proteomics 7, 337-346 (2010)
21. T. Efferth, A. Olbrich, R. Bauer, Biochem. Pharmacol. 64, 617-623 (2002)
22. T. Efferth, A. Sauerbrey, A. Olbrich, E. Gebhart, P. Rauch, H.O. Weber, J.G. Hengstler, M.E. Halatsch, M. Volm, K.D. Tew, D.D. Ross, J.O. Funk, Mol. Pharmacol. 64, 382-394 (2003)
23. V.B. Konkimalla, M. Blunder, B. Korn, S.A. Soomro, H. Jansen, W. Chang, G.H. Posner, R. Bauer, T. Efferth, Nitric Oxide 19, 184-191 (2008)
24. V.B. Konkimalla, J.A. McCubrey, T. Efferth, Curr. Cancer Drug Targets 9, 72-80 (2009)
25. S. Sertel, T. Eichhorn, C.H. Simon, P.K. Plinkert, S.W. Johnson, T. Efferth, Molecules 15, 2886-2910 (2010)
26. B. Bachmeier, I. Fichtner, P.H. Killian, E. Kronski, U. Pfeffer, T. Efferth, PLoS One 6, e20550 (2011)
27. T. Efferth, M. Giaisi, A. Merling, P.H. Krammer, M. Li-Weber, PLoS One 2, e693 (2007)
28. M. Ramacher, V. Umansky, T. Efferth, Anticancer Drugs 20, 910-917 (2009)
29. S. Sieber, G. Gdynia, W. Roth, B. Bonavida, T. Efferth, Int. J. Oncol. 35, 149-158 (2009)
30. A. Hamacher-Brady, H.A. Stein, S. Turschner, I. Toegel, R. Mora, N. Jennewein, T. Efferth, R. Eils, N.R. Brady, J. Biol. Chem. 286, 6587-6601 (2011)
31. S. Reichert, V. Reinboldt, S. Hehlgans, T. Efferth, C. Rodel, F. Rodel, Radiother. Oncol. 103, 394-401 (2012)
32. R. Dell'Eva, U. Pfeffer, R. Vené, L. Anfosso, A. Forlani, A. Albini, T. Efferth, Biochem. Pharmacol. 68, 2359-2366 (2004)
33. L. Anfosso, T. Efferth, A. Albini, U. Pfeffer, Pharmacogenomics J. 6, 269-278 (2006)
34. S. Soomro, T. Langenberg, A. Mahringer, V.B. Konkimalla, C. Horwedel, P. Holenya, A. Brand, C. Cetin, G. Fricker, M. Dewerchin, P. Carmeliet, E.M. Conway, H. Jansen, T. Efferth, J. Cell Mol. Med. 15, 1122-1135 (2011)
35. B. Krusche, J. Arend, T. Efferth, Evid. Based Complement. Alternat. Med. 454783 (2013)
36. H.J. Zhou, J.L. Zhang, A. Li, Z. Wang, X.E. Lou, Cancer Chemother. Pharmacol. 66, 21-29 (2010)
37. N.P. Singh, H.C. Lai, J.S. Park, T.E. Gerhardt, B.J. Kim, S. Wang, T. Sasaki, Anticancer Res. 31, 4111-4114 (2011)
38. S. Noori, Z.M. Hassan, Cell. Immunol. 271, 67-72 (2011)
39. J. Hou, D. Wang, R. Zhang, H. Wang, Clin. Cancer Res. 14, 5519-5530 (2008)
40. T. Chen, M. Li, R. Zhang, H. Wang, J. Cell Mol. Med. 13, 1358-1370 (2009)
41. H. Chen, B. Sun, S. Pan, H. Jiang, X. Sun, Anticancer Drugs 20, 131-140 (2009)
42. J.H. Du, H.D. Zhang, Z.J. Ma, K.M. Ji, Cancer Chemother. Pharmacol. 65, 895-902 (2010)
43. N. Gao, A. Budhraja, S. Cheng, E.H. Liu, C. Huang, J. Chen, Z. Yang, D. Chen, Z. Zhang, X. Shi, Apoptosis 16, 511-523 (2011)
44. A.S. Tin, S.N. Sundar, K.Q. Tran, A.H. Park, K.M. Poindexter, G.L. Firestone, Anticancer Drugs 23, 370-379 (2012)
45. C.Z. Zhang, H. Zhang, J. Yun, G.G. Chen, P.B. Lai, Biochem. Pharmacol. 83, 1278-1289 (2012)
46. J.L. Zhang, Z. Wang, W. Hu, S.S. Chen, X.E. Lou, H.J. Zhou, Microvasc. Res. 87, 14-24 (2013)
47. H. Sun, X. Meng, J. Han, Z. Zhang, B. Wang, X. Bai, X. Zhang, Tumour Biol. 34, 3791-3800 (2013)
48. N.P. Singh, K.B. Verma, Arch. Oncol. 10, 279-280 (2002)
49. T.G. Berger, D. Dieckmann, T. Efferth, E.S. Schultz, J.O. Funk, A. Baur, G. Schuler, Oncol. Rep. 14, 1599-1603 (2005)
50. G.R. Rutteman, S.A. Erich, J.A. Mol, B. Spee, G.C. Grinwis, L. Fleckenstein, C.A. London, T. Efferth, Anticancer Res. 33, 1819-1827 (2013)
51. Jansen FH, Adoubi I, J C KC, DE Cnodder T, Jansen N, Tschulakow A, Efferth T. Anticancer Res. 2011, 31, 4417-4422
52. M.A. Atemnkeng, B. Chimanuka, B. Dejaegher, Y.V. Heyden, J. Plaizier-Vercammen, Exp. Parasitol. 122, 344-348 (2009)
53. M.U. Eteng, A.O. Abolaji, P.E. Ebong, E.A. Brisibe, A. Dar, N. Kabir, M. Iqbal Choudhary, Phytother. Res. 27, 602-609 (2013)
54. M.S. Müller, N. Runyambo, I. Wagner, S. Borrmann, K. Dietz, L. Heide, Trans. R. Soc. Trop. Med. Hyg. 98, 318-321 (2004)
55. RITAM Artemisia annua Task Force, M. Willcox, J. Falquet, J.F. Ferreira, B. Gilbert, E. Hsu, P.M. de Magalhaes, J. PlaizierVercammen, V.P. Sharma, C.W. Wright, W. Yaode, Afr. J. Tradit. Complement. Altern. Med. 4, 121-123 (2006)
56. C.H. Blanke, G.B. Naisabha, M.B. Balema, G.M. Mbaruku, L. Heide, M.S. Müller, Trop. Doctor 38, 113-116 (2008)
57. P. Rasoanaivo, C.W. Wright, M.L. Willcox, B. Gilbert, Malaria J. 10(Suppl 1), S4 (2011)
58. F. van der Kooy, S.E. Sullivan, J. Ethnopharmacol. 150, 1-13 (2013)
59. M.S. Müller, I.B. Karhagomba, H.M. Hirt, E. Wemakor, J. Ethnopharmacol. 73, 487-493 (2000)
60. S. de Ridder, F. van der Kooy, R. Verpoorte, J. Ethnopharmacol. 120, 302-314 (2008)
61. T. Efferth, F. Herrmann, A. Tahrani, M. Wink, Phytomedicine 18, 959-969 (2011)
62. N.P. Singh, J.F. Ferreira, J.S. Park, H.C. Lai, Planta Med. 77, 1788-1793 (2011)
63. E.G. MacEwen, Cancer Metast. Rev. 9, 125-136 (1990)
64. Chinese Pharmacopeia Commission, Pharmacopoeia of the People's Republic of China 2010 (Deutscher Apotheker Verlag, Stuttgart, 2011)
65. C. Righeschi, T. Eichhorn, A. Karioti, A.R. Bilia, T. Efferth, Cancer Genomics Proteomics 9, 143-151 (2012)
66. B.A. Teicher, Mol. Cancer Ther. 5, 2435-2443 (2006)
67. G.L. Disbrow, A.C. Baege, K.A. Kierpiec, H. Yuan, J.A. Centeno, C.A. Thibodeaux, D. Hartmann, R. Schlegel, Cancer Res. 65, 10854-10861 (2005)
68. S.A. Frazier, S.M. Johns, J. Ortega, A.L. Zwingenberger, M.S. Kent, G.M. Hammond, C.O. Rodriguez Jr, M.A. Steffey, K.A. Skorupski, Vet. Comp. Oncol. 10, 33-43 (2012)
69. W.M. Adams, P.E. Miller, D.M. Vail, L.J. Forrest, E.G. MacEwen, Vet. Radiol. Ultrasound. 39, 475-481 (1998)
70. A.P. Theon, B.R. Madewell, M.F. Harb, D.L. Dungworth, J. Am. Vet. Med. Assoc. 202, 1469-1475 (1993)
71. W.M. Adams, S.J. Withrow, R. Walshaw, J.M. Turrell, S.M. Evans, M.A. Walker, I.D. Kurzman, J. Am. Vet. Med. Assoc. 191, 311-315 (1987)
72. M.E. Nadeau, B.E. Kitchell, R.L. Rooks, S.M. LaRue, Vet. Radiol. Ultrasound. 45, 362-367 (2004)
73. W.M. Adams, D.E. Bjorling, J.E. McAnulty, E.M. Green, L.J. Forrest, D.M. Vail, J. Am. Vet. Med. Assoc. 227, 936-941 (2005)
74. S.E. Lana, W.S. Dernell, M.H. Lafferty, S.J. Withrow, S.M. LaRue, Vet. Radiol. Ultrasound. 45, 577-581 (2004)
75. V. Langova, A.J. Mutsaers, B. Phillips, R. Straw, Aust. Vet. J. 82, 676-680 (2004)
76. Y.Y. Tu, M.Y. Ni, Y.R. Zhong, L.N. Li, S.L. Cui, M.Q. Zhang, X.Z. Wang, Z. Ji, X.T. Liang, Planta Med. 44, 143-145 (1982)
77. J. Han, M. Ye, X. Qiao, M. Xu, B.R. Wang, D.A. Guo, J. Pharm. Biomed. Anal. 47, 516-525 (2008)
78. T. Carbonara, R. Pascale, M.P. Argentieri, P. Papadia, F.P. Fanizzi, L. Villanova, P. Avato, J. Pharm. Biomed. Anal. 62, 79-86 (2012)
79. N.S. Radulović, P.J. Randjelović, N.M. Stojanović, P.D. Blagojević, Z.Z. Stojanović-Radić, I.R. Ilić, V.B. Djordjević, Food Chem. Toxicol. 58, 37-49 (2013)
80. X.L. Liu, L. Zhang, X.L. Fu, K. Chen, B.C. Qian, Acta Pharmacol. Sin. 22, 929-933 (2001)
81. M. Adams, T. Efferth, R. Bauer, Planta Med. 72, 862-864 (2006)
82. X. Cai, J. Yang, J. Zhou, W. Lu, C. Hu, Z. Gu, J. Huo, X. Wang, P. Cao, Bioorg. Med. Chem. 21, 84-92 (2013)

[1]	Yunqin Zhang, Guowei Xu, Shuqun Zhang, Dong Wang, P. Saravana Prabha, Zhili Zuo. Antitumor Research on Artemisinin and Its Bioactive Derivatives [J]. Natural Products and Bioprospecting, 2018, 8(4): 303-319.
[2]	Hui Liu, Xingyong Liu, Li Zhang. Computational Analysis of Artimisinin Derivatives on the Antitumor Activities [J]. Natural Products and Bioprospecting, 2017, 7(6): 433-443.
[3]	Mounir Tilaoui, Hassan Ait Mouse, Abdeslam Jaafari, Abdelmajid Zyad. Differential Effect of Artemisinin Against Cancer Cell Lines [J]. Natural Products and Bioprospecting, 2014, 4(3): 189-196.
[4]	Shilpi PAUL, Madan M GUPTA, Suman P S KHANUJA. Maintaining the artemisinin content through direct and indirect in vitro regeneration and their assessment of variations with the field grown mother plants of Artemisia annua L. [J]. Natural Products and Bioprospecting, 2012, 2(5): 194-199.