Abstract: Nine previously-unreported farnesylphenols, involving eight neogrifolin derivatives(1-8) and one grifolin analogue(9), together with three known compounds, were isolated from the fruiting bodies of the mushroom Albatrellus caeruleoporus. Their structures were elucidated as(S)-17-hydroxy-18, 20-ene-neogrifolin(1),(S)-18, 19-dihydroxyneogrifolin(2),(S)-9-hydroxy-10, 22-ene-neogrifolin(3),(9S, 10R)-6, 10-epoxy-9-hydroxyneo grifolin(4),(9S, 10R)-6, 9-epoxy-10-hydroxyneogrifolin(5),(-)-13, 14-dihydroxyneogrifolin(6), albatrelin G(7), albatrelin H(8), and one grifolin analogue,(S)-10-hydroxygrifolin(9), grifolin(10), neogrifolin(11), and albatrellin(12) by extensive spectroscopic analyses and chemical methods. Compounds 7 and 8 showed weak cytotoxic activity to cell lines HL-60, SMMC-7721, A-549, and MCF-7, in vitro.

Key words: Albatrellus caeruleoporus, Mushroom, Polyporaceae, Farnesylphenols

摘要： Nine previously-unreported farnesylphenols, involving eight neogrifolin derivatives(1-8) and one grifolin analogue(9), together with three known compounds, were isolated from the fruiting bodies of the mushroom Albatrellus caeruleoporus. Their structures were elucidated as(S)-17-hydroxy-18, 20-ene-neogrifolin(1),(S)-18, 19-dihydroxyneogrifolin(2),(S)-9-hydroxy-10, 22-ene-neogrifolin(3),(9S, 10R)-6, 10-epoxy-9-hydroxyneo grifolin(4),(9S, 10R)-6, 9-epoxy-10-hydroxyneogrifolin(5),(-)-13, 14-dihydroxyneogrifolin(6), albatrelin G(7), albatrelin H(8), and one grifolin analogue,(S)-10-hydroxygrifolin(9), grifolin(10), neogrifolin(11), and albatrellin(12) by extensive spectroscopic analyses and chemical methods. Compounds 7 and 8 showed weak cytotoxic activity to cell lines HL-60, SMMC-7721, A-549, and MCF-7, in vitro.

关键词: Albatrellus caeruleoporus, Mushroom, Polyporaceae, Farnesylphenols