New Taxane Diterpenoids from Taxus yunnanensis

doi:10.1007/s13659-014-0003-9

Natural Products and Bioprospecting ›› 2014, Vol. 4 ›› Issue (1): 47-51.DOI: 10.1007/s13659-014-0003-9

• Original article • Previous Articles Next Articles

New Taxane Diterpenoids from Taxus yunnanensis

Ping Hai¹, Shi-Zhen Wen¹, Yan Li², Yuan Gao^1,2, Xian-Jun Jiang¹, Fei Wang^1,2

1. BioBioPha Co., Ltd., Kunming 650201, China;
2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China

Received:2013-11-26 Revised:2014-01-12 Online:2018-02-11 Published:2014-02-24
Supported by:
This work was financially supported by the "Large-scale Compound Library" project of National Development and Reform Commission of China and the "Western Light" talents training program of Chinese Academy of Sciences.

New Taxane Diterpenoids from Taxus yunnanensis

Ping Hai¹, Shi-Zhen Wen¹, Yan Li², Yuan Gao^1,2, Xian-Jun Jiang¹, Fei Wang^1,2

1. BioBioPha Co., Ltd., Kunming 650201, China;
2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China

通讯作者: Fei Wang,e-mail:wangfei@mail.kib.ac.cn
基金资助:
This work was financially supported by the "Large-scale Compound Library" project of National Development and Reform Commission of China and the "Western Light" talents training program of Chinese Academy of Sciences.

Abstract

Abstract: Three hitherto unknown taxane diterpenoids, namely baccatin VIII(1), baccatin IX(2), and baccatin X(3), along with 10 known analogues were isolated from an ethanolic extract of the twigs and leaves of Taxus yunnanensis. The new structures were characterized based on extensive spectroscopic analysis. Compounds 1 and 2 were tested for their in vitro cytotoxicity against five human tumor cell lines, and 1 exhibited inhibitory effects on HL-60 and MCF-7, with IC₅₀ values of 3.44 and 9.67 μM, respectively.

Key words: Taxus yunnanensis, Taxane, Baccatin, Cytotoxicity

摘要： Three hitherto unknown taxane diterpenoids, namely baccatin VIII(1), baccatin IX(2), and baccatin X(3), along with 10 known analogues were isolated from an ethanolic extract of the twigs and leaves of Taxus yunnanensis. The new structures were characterized based on extensive spectroscopic analysis. Compounds 1 and 2 were tested for their in vitro cytotoxicity against five human tumor cell lines, and 1 exhibited inhibitory effects on HL-60 and MCF-7, with IC₅₀ values of 3.44 and 9.67 μM, respectively.

关键词: Taxus yunnanensis, Taxane, Baccatin, Cytotoxicity

Ping Hai, Shi-Zhen Wen, Yan Li, Yuan Gao, Xian-Jun Jiang, Fei Wang. New Taxane Diterpenoids from Taxus yunnanensis[J]. Natural Products and Bioprospecting, 2014, 4(1): 47-51.

Ping Hai, Shi-Zhen Wen, Yan Li, Yuan Gao, Xian-Jun Jiang, Fei Wang. New Taxane Diterpenoids from Taxus yunnanensis[J]. 应用天然产物, 2014, 4(1): 47-51.

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New Taxane Diterpenoids from Taxus yunnanensis

New Taxane Diterpenoids from Taxus yunnanensis

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