Chemical components of Dendrobium crepidatum and their neurite outgrowth enhancing activities

doi:10.1007/s13659-012-0103-3

Natural Products and Bioprospecting ›› 2013, Vol. 3 ›› Issue (2): 70-73.DOI: 10.1007/s13659-012-0103-3

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Chemical components of Dendrobium crepidatum and their neurite outgrowth enhancing activities

Cheng-Bo LI^a, Cong WANG^a,b, Wei-Wei FAN^a,b, Fa-Wu DONG^a,b, Feng-Qing XU^a,b, Qin-Li WAN^a, Huai-Rong LUO^a, Yu-Qing LIU^a, Jiang-Miao HU^a, Jun ZHOU^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b University of Chinese Academy of Sciences, Beijing 100049, China

Received:2012-12-25 Revised:2013-02-28 Online:2018-02-11 Published:2013-04-24
Supported by:
This work was financially supported by National Natural and Science Foundations of China (No. 30800090), "Xi-BuZhi-Guang" project (2009-2012) from Chinese Academy of Science and the Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China (P2010-ZZ012). The authors are grateful to the members of the analytical group of the State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, for all the spectral measurements.

Chemical components of Dendrobium crepidatum and their neurite outgrowth enhancing activities

Cheng-Bo LI^a, Cong WANG^a,b, Wei-Wei FAN^a,b, Fa-Wu DONG^a,b, Feng-Qing XU^a,b, Qin-Li WAN^a, Huai-Rong LUO^a, Yu-Qing LIU^a, Jiang-Miao HU^a, Jun ZHOU^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b University of Chinese Academy of Sciences, Beijing 100049, China

通讯作者: Jun ZHOU,E-mail:hujiangmiao@mail.kib.ac.cn
基金资助:
This work was financially supported by National Natural and Science Foundations of China (No. 30800090), "Xi-BuZhi-Guang" project (2009-2012) from Chinese Academy of Science and the Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China (P2010-ZZ012). The authors are grateful to the members of the analytical group of the State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, for all the spectral measurements.

Abstract

Abstract: 15 compounds, including two new ones crepidatuols A (1) and B (2) were isolated from the stems of Dendrobium crepidatum. The planar structures of these compounds were elucidated by spectroscopic methods (NMR, MS, UV, and IR) and comparison with those from literatures. 10 compounds were send for enhancing activities on nerve growth factor (NGF) medicated neurite outgrowth in PC12 cells and the results indicated that crepidatuol A (1), confusarin and 3-(2-acetoxy-5-methoxy)-phenylpropanol showed enhancing activities at the concentration of 10.0 μM.

Key words: Orchidaceae, Dendrobium crepidatum, bibenzyl, neurite outgrowth enhancing activity

摘要： 15 compounds, including two new ones crepidatuols A (1) and B (2) were isolated from the stems of Dendrobium crepidatum. The planar structures of these compounds were elucidated by spectroscopic methods (NMR, MS, UV, and IR) and comparison with those from literatures. 10 compounds were send for enhancing activities on nerve growth factor (NGF) medicated neurite outgrowth in PC12 cells and the results indicated that crepidatuol A (1), confusarin and 3-(2-acetoxy-5-methoxy)-phenylpropanol showed enhancing activities at the concentration of 10.0 μM.

关键词: Orchidaceae, Dendrobium crepidatum, bibenzyl, neurite outgrowth enhancing activity

Cheng-Bo LI, Cong WANG, Wei-Wei FAN, Fa-Wu DONG, Feng-Qing XU, Qin-Li WAN, Huai-Rong LUO, Yu-Qing LIU, Jiang-Miao HU, Jun ZHOU. Chemical components of Dendrobium crepidatum and their neurite outgrowth enhancing activities[J]. Natural Products and Bioprospecting, 2013, 3(2): 70-73.

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Chemical components of Dendrobium crepidatum and their neurite outgrowth enhancing activities

Chemical components of Dendrobium crepidatum and their neurite outgrowth enhancing activities

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