Three new triterpenoids from Rubia schumanniana

doi:10.1007/s13659-012-0038-8

Natural Products and Bioprospecting ›› 2012, Vol. 2 ›› Issue (4): 166-169.DOI: 10.1007/s13659-012-0038-8

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Three new triterpenoids from Rubia schumanniana

Bin KUANG^a,b, Jing HAN^a,b, Guang-Zhi ZENG^a, Xiao-Qiang CHEN^a, Wen-Jun HE^a, Ning-Hua TAN^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100049, China

Received:2012-05-15 Revised:2012-06-25 Online:2018-02-11 Published:2012-08-24
Supported by:
This work was supported by the National Natural Science Foundation of China(U1032602, 91013002, 30725048), the National New Drug Innovation Major Project of China(2011ZX09307-002-02), and the National Basic Reaearch Program of China(2009 CB522300).

Three new triterpenoids from Rubia schumanniana

Bin KUANG^a,b, Jing HAN^a,b, Guang-Zhi ZENG^a, Xiao-Qiang CHEN^a, Wen-Jun HE^a, Ning-Hua TAN^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100049, China

通讯作者: Ning-Hua TAN,E-mail:nhtan@mail.kib.ac.cn
基金资助:
This work was supported by the National Natural Science Foundation of China(U1032602, 91013002, 30725048), the National New Drug Innovation Major Project of China(2011ZX09307-002-02), and the National Basic Reaearch Program of China(2009 CB522300).

Abstract

Abstract: Three new triterpenoids, 3β-hydroxy-urs-30-p-Z-hydroxycinnamoyl-12-en-28-oic-acid(1), 3β-hydroxy-olean-30-p-E-hydroxycinnamoyl-12-en-28-oic-acid(2) and 3β, 6α-dihydroxy-urs-14-en-12-one(3), together with seven known triterpenoids, were isolated from the roots of Rubia schumanniana. Their structures were established by means of spectroscopic analysis. All compounds were evaluated for cytotoxic activity, and compounds 2-6 showed cytotoxicity with the IC₅₀ values of 10.75~18.87 μg/mL.

Key words: Rubia schumanniana, triterpenoid, cytotoxicity

摘要： Three new triterpenoids, 3β-hydroxy-urs-30-p-Z-hydroxycinnamoyl-12-en-28-oic-acid(1), 3β-hydroxy-olean-30-p-E-hydroxycinnamoyl-12-en-28-oic-acid(2) and 3β, 6α-dihydroxy-urs-14-en-12-one(3), together with seven known triterpenoids, were isolated from the roots of Rubia schumanniana. Their structures were established by means of spectroscopic analysis. All compounds were evaluated for cytotoxic activity, and compounds 2-6 showed cytotoxicity with the IC₅₀ values of 10.75~18.87 μg/mL.

关键词: Rubia schumanniana, triterpenoid, cytotoxicity

Bin KUANG, Jing HAN, Guang-Zhi ZENG, Xiao-Qiang CHEN, Wen-Jun HE, Ning-Hua TAN. Three new triterpenoids from Rubia schumanniana[J]. Natural Products and Bioprospecting, 2012, 2(4): 166-169.

Bin KUANG, Jing HAN, Guang-Zhi ZENG, Xiao-Qiang CHEN, Wen-Jun HE, Ning-Hua TAN. Three new triterpenoids from Rubia schumanniana[J]. 应用天然产物, 2012, 2(4): 166-169.

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Three new triterpenoids from Rubia schumanniana

Three new triterpenoids from Rubia schumanniana

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