Integrative Biology Journals
Natural Products and Bioprospecting

Natural Products and Bioprospecting ›› 2012, Vol. 2 ›› Issue (3): 126-129.DOI: 10.1007/s13659-012-0028-x

• Regular Article • Previous Articles     Next Articles

β-Carboline alkaloids from Trigonostemon filipes and Trigonostemon lii

Shi-Fei LIa,b, Yuan-Yuan CHENGa,b, Yu ZHANGa, Shun-Lin LIa, Hong-Ping HEa, Xiao-Jiang HAOa   

  1. a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
    b Graduate University of Chinese Academy of Sciences, Beijing 100049, China
  • Received:2012-03-28 Revised:2012-04-22 Online:2018-02-11 Published:2012-06-24
  • Supported by:
    This work was supported financially by the National Natural Science Foundation of China(30830114 and 21072199), the Ministry of Science and Technology of China(2009CB522300 and 2009CB940900), the Natural Science Fund of Yunnan Province(2009CD112), the Foundation of Chinese Academy of Sciences to H. P. He, the Yong Academic and Technical Leader Raising Foundation of Yunnan Province(2010CI047).

β-Carboline alkaloids from Trigonostemon filipes and Trigonostemon lii

Shi-Fei LIa,b, Yuan-Yuan CHENGa,b, Yu ZHANGa, Shun-Lin LIa, Hong-Ping HEa, Xiao-Jiang HAOa   

  1. a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
    b Graduate University of Chinese Academy of Sciences, Beijing 100049, China
  • 通讯作者: Hong-Ping HE,E-mail:hehongping@mail.kib.ac.cn;Xiao-Jiang HAO,E-mail:haoxj@mail.kib.ac.cn
  • 基金资助:
    This work was supported financially by the National Natural Science Foundation of China(30830114 and 21072199), the Ministry of Science and Technology of China(2009CB522300 and 2009CB940900), the Natural Science Fund of Yunnan Province(2009CD112), the Foundation of Chinese Academy of Sciences to H. P. He, the Yong Academic and Technical Leader Raising Foundation of Yunnan Province(2010CI047).

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Abstract: Six β-carboline alkaloids including three new ones, trifilines A-C(1-3) were isolated from Trigonostemon filipes, along with a new β-carboline alkaloid, trigonoine C(7) isolated from Trigonostemon lii. Their structures were elucidated by extensive spectroscopic techniques. Trifilines A(1) and B(2) showed weak anti-HIV-1 activity with EC50 values of 54.61 μg/mL and 9.75 μg/mL, along with TI(Therapeutic index) values of 1.52 and 1.42, respectively. This is the first time to report the chemical constituents of Trigonostemon filipes.

Key words: Trigonostemon filipes, Trigonostemon lii, β-carboline alkaloids, trifilines A-C, trigonoine C

摘要： Six β-carboline alkaloids including three new ones, trifilines A-C(1-3) were isolated from Trigonostemon filipes, along with a new β-carboline alkaloid, trigonoine C(7) isolated from Trigonostemon lii. Their structures were elucidated by extensive spectroscopic techniques. Trifilines A(1) and B(2) showed weak anti-HIV-1 activity with EC50 values of 54.61 μg/mL and 9.75 μg/mL, along with TI(Therapeutic index) values of 1.52 and 1.42, respectively. This is the first time to report the chemical constituents of Trigonostemon filipes.

关键词: Trigonostemon filipes, Trigonostemon lii, β-carboline alkaloids, trifilines A-C, trigonoine C

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