Dammarane-type saponins from steamed leaves of Panax notoginseng

doi:10.1007/s13659-011-0036-2

Natural Products and Bioprospecting ›› 2011, Vol. 1 ›› Issue (3): 124-128.DOI: 10.1007/s13659-011-0036-2

• Regular Article • Previous Articles Next Articles

Dammarane-type saponins from steamed leaves of Panax notoginseng

Qing LIU^a, Jun-Jiang LV^a,b, Min XU^a, Dong WANG^a, Hong-Tao ZHU^a, Chong-Ren YANG^a,c, Ying-Jun ZHANG^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100049, China;
c Weihe Biotech Research and Development Center, Yuxi 653101, China

Received:2011-11-22 Revised:2011-12-11 Online:2018-02-11 Published:2011-06-24
Supported by:
The authors are grateful to the members of the analytical group at State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, for measuring all the spectroscopic data. This work was supported by the 973 Program of Ministry of Science and Technology of China(2011CB915503).

Dammarane-type saponins from steamed leaves of Panax notoginseng

Qing LIU^a, Jun-Jiang LV^a,b, Min XU^a, Dong WANG^a, Hong-Tao ZHU^a, Chong-Ren YANG^a,c, Ying-Jun ZHANG^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100049, China;
c Weihe Biotech Research and Development Center, Yuxi 653101, China

通讯作者: Ying-Jun ZHANG,E-mail:zhangyj@mail.kib.ac.cn
基金资助:
The authors are grateful to the members of the analytical group at State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, for measuring all the spectroscopic data. This work was supported by the 973 Program of Ministry of Science and Technology of China(2011CB915503).

Abstract

Abstract: Four new dammarane-type triterpenoid saponins, namely notoginsenosides SFt₁-SFt₄(1-4) were isolated from the steamed leaves of Panax notoginseng(Burk.) F. H. Chen(Araliaceae), together with 17 known saponins. Their structures were established on the basis of detailed spectroscopic analyses and acidic hydrolysis. The known ginsenosides Rk₂ and Rh3 were obtained from P. notoginseng for the first time. All of these new saponins showed no in vitro cytotoxicity against five human cancer cell lines(HL-60, SMMC-7712, A-549, MCF-7, and SW480).

Key words: Panax notoginseng, steamed leave, dammarane-type saponin, notoginsenoside

摘要： Four new dammarane-type triterpenoid saponins, namely notoginsenosides SFt₁-SFt₄(1-4) were isolated from the steamed leaves of Panax notoginseng(Burk.) F. H. Chen(Araliaceae), together with 17 known saponins. Their structures were established on the basis of detailed spectroscopic analyses and acidic hydrolysis. The known ginsenosides Rk₂ and Rh3 were obtained from P. notoginseng for the first time. All of these new saponins showed no in vitro cytotoxicity against five human cancer cell lines(HL-60, SMMC-7712, A-549, MCF-7, and SW480).

关键词: Panax notoginseng, steamed leave, dammarane-type saponin, notoginsenoside

Qing LIU, Jun-Jiang LV, Min XU, Dong WANG, Hong-Tao ZHU, Chong-Ren YANG, Ying-Jun ZHANG. Dammarane-type saponins from steamed leaves of Panax notoginseng[J]. Natural Products and Bioprospecting, 2011, 1(3): 124-128.

Qing LIU, Jun-Jiang LV, Min XU, Dong WANG, Hong-Tao ZHU, Chong-Ren YANG, Ying-Jun ZHANG. Dammarane-type saponins from steamed leaves of Panax notoginseng[J]. 应用天然产物, 2011, 1(3): 124-128.

References

[1] Ye D. D. J. Changchun Univ. Tradit. Chin. Med. 2007. 23, 104-105.
[2] Ye, D. J.; Zhang, S. C. Herbs from roots and rhizomes. Chinese Medicinal Herbs Preparation. People's Medical Publishing House:Peking, China, 1999; p 187.
[3] Zhang, J. T. Ren Shen Guan Bai Cao:The Chemistry, Metabolism and Biological Activities of Ginseng. Chemical Industry Press:Beijing, 2008; chapter 3, pp 34-44.
[4] Liao, P. Y.; Wang, D.; Zhang, Y. J.; Yang, C. R. J. Agric. Food Chem. 2008, 56, 1751-1756.
[5] Li, P. Y.; Liu, J. P.; Lu, D.; Liu, C. G.; Du, X. J.; Li, F. 2011, Chinese Patent No. CN 101948497A.
[6] Park, I. H.; Kim, N. Y.; Han, S. B.; Kim, J. M.; Kwon, S. W.; Kim, H. J.; Park, M. K.; Park, J. H. Arch. Pharm. Res. 2002, 25, 428-432.
[7] Park, I. H.; Han, S. B.; Kim, J. M.; Piao, L. Z.; Kwon, S. W.; Kim, N. Y.; Kang, T. L.; Park, M. K.; Park, J. H. Arch. Pharm. Res. 2002, 25, 837-841.
[8] Li, H. Z.; Zhang, Y. J.; Yang, C. R. Nat. Prod. Res. Dev. 2006, 18, 549-554.
[9] Teng, R. W.; Li, H. Z.; Wang, D. Z.; He, Y. N.; Yang, C. R. Chin. J. Magn. Reson. 2000, 17, 461-468.
[10] Baek, N. I.; Kim, J. M.; Park, J. H.; Ryu, J. H.; Kim, D. S.; Lee, Y. H.; Park, J. D.; Kim, S. I. Arch. Pharm. Res. 1997, 20, 280-282.
[11] Chen, J. T.; Li, H. Z.; Wang, D.; Zhang, Y. J.; Yang, C. R. Helv. Chim. Acta 2006, 89, 1442-1447.
[12] Yang, T. R.; Kasai, R.; Zhou, J.; Tanaka, O. Phytochemistry 1983, 22, 1473-1478.
[13] Yu, M.; Zhao, Y. Q. Chin. Trad. Herbal Drugs 2002, 33, 404-405.
[14] Usami, Y.; Liu, Y. N.; Lin, A. S.; Shibano, M.; Akiyama, T.; Itokawa, H.; Morris-Natschke, S. L.; Bastow, K.; Kasai, R.; Lee, K. H. J. Nat. Prod. 2008, 71, 478-481.
[15] Dou, D. Q.; Chen, Y. J.; Liang, L. H.; Pang, F. G.; Shimizu, N.; Takeda, T. Chem. Pharm. Bull. 2001, 49, 442-446.
[16] Feng, S. B.; Wang, X. S.; Wang, D. Q.; Yang, C. R.; Zhou, J. Acta Bot. Yunnan. 1987, 9, 477-488.
[17] Kucherbaev, K. D.; Uteniyazov, K. K.; Saatov, Z.; Shashkov, A. S. Chem. Nat. Comp. 2002, 38, 447-449.
[18] Zhao, Z.; Matsunami, K.; Otsaka, H.; Shinzato, T.; Takeda, Y. Chem. Pharm. Bull. 2008, 56, 1153-1158.
[19] Mosmann, T. J. Immunol. Methods 1983, 65, 55-63.

Dammarane-type saponins from steamed leaves of Panax notoginseng

Dammarane-type saponins from steamed leaves of Panax notoginseng

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 2

Recommended Articles

Metrics

Comments

[1]	Jia-Huan Shang, Guo-Wei Xu, Hong-Tao Zhu, Dong Wang, Chong-Ren Yang, Ying-Jun Zhang. Anti-inflammatory and Cytotoxic Triterpenes from the Rot Roots of Panax notoginseng [J]. Natural Products and Bioprospecting, 2019, 9(4): 287-295.
[2]	Wen-Jie Sun, Hong-Tao Zhu, Tian-Yuan Zhang, Meng-Yue Zhang, Dong Wang, Chong-Ren Yang, Yi-Xuan Zhang, Ying-Jun Zhang. Two New Alkaloids from Fusarium tricinctum SYPF 7082, an Endophyte from the Root of Panax notoginseng [J]. Natural Products and Bioprospecting, 2018, 8(5): 391-396.