Three new indole alkaloids from Rauvolfia yunnanensis

doi:10.1007/s13659-011-0023-7

Natural Products and Bioprospecting ›› 2011, Vol. 1 ›› Issue (3): 104-107.DOI: 10.1007/s13659-011-0023-7

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Three new indole alkaloids from Rauvolfia yunnanensis

Yuan GAO^a,b,c, Fei WANG^a,b, Dong-Sheng ZHOU^b, Yan LI^a, Ji-Kai LIU^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b BioBioPha Co., Ltd., Kunming 650201, China;
c Graduate University of Chinese Academy of Sciences, Beijing 100049, China

Received:2011-10-11 Revised:2011-11-23 Online:2018-02-11 Published:2011-06-24
Supported by:
This work was financially supported by National Basic Research Program of China(973 Program)2009CB522300, the "West Light" program of Chinese Academy of Sciences, and Natural Product Library Program of BioBioPha.

Three new indole alkaloids from Rauvolfia yunnanensis

Yuan GAO^a,b,c, Fei WANG^a,b, Dong-Sheng ZHOU^b, Yan LI^a, Ji-Kai LIU^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b BioBioPha Co., Ltd., Kunming 650201, China;
c Graduate University of Chinese Academy of Sciences, Beijing 100049, China

通讯作者: Ji-Kai LIU,E-mail:jkliu@mail.kib.ac.cn
基金资助:
This work was financially supported by National Basic Research Program of China(973 Program)2009CB522300, the "West Light" program of Chinese Academy of Sciences, and Natural Product Library Program of BioBioPha.

Abstract

Abstract: One rare tetracyclic macroline-type indole alkaloid, named rauvoyunine A(1), and two new picraline-type alkaloids rauvoyunines B and C(2 and 3) were isolated from the aerial parts of Rauvolfia yunnanensis. Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 2 and 3 were evaluated for their in vitro cytotoxicity against five human tumor cell lines.

Key words: Rauvolfia yunnanensis, indole alkaloid, rauvoyunine

摘要： One rare tetracyclic macroline-type indole alkaloid, named rauvoyunine A(1), and two new picraline-type alkaloids rauvoyunines B and C(2 and 3) were isolated from the aerial parts of Rauvolfia yunnanensis. Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 2 and 3 were evaluated for their in vitro cytotoxicity against five human tumor cell lines.

关键词: Rauvolfia yunnanensis, indole alkaloid, rauvoyunine

Yuan GAO, Fei WANG, Dong-Sheng ZHOU, Yan LI, Ji-Kai LIU. Three new indole alkaloids from Rauvolfia yunnanensis[J]. Natural Products and Bioprospecting, 2011, 1(3): 104-107.

Yuan GAO, Fei WANG, Dong-Sheng ZHOU, Yan LI, Ji-Kai LIU. Three new indole alkaloids from Rauvolfia yunnanensis[J]. 应用天然产物, 2011, 1(3): 104-107.

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Three new indole alkaloids from Rauvolfia yunnanensis

Three new indole alkaloids from Rauvolfia yunnanensis

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