Neolignans from Selaginella moellendorffii

doi:10.1007/s13659-016-0095-5

应用天然产物 ›› 2016, Vol. 6 ›› Issue (3): 161-166.DOI: 10.1007/s13659-016-0095-5

• Original article • 上一篇下一篇

Neolignans from Selaginella moellendorffii

Jing-Xian Zhuo¹, Yue-Hu Wang¹, Xing-Li Su², Ren-Qiang Mei¹, Jun Yang¹, Yi Kong², Chun-Lin Long^1,3

1. Key Laboratory of Economic Plants and Biotechnology, and Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2. School of Life Science & Technology, China Pharmaceutical University, Nanjing 210009, China;
3. College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China

收稿日期:2016-02-05 修回日期:2016-03-20 出版日期:2016-06-24 发布日期:2018-02-08
通讯作者: Yue-Hu Wang,e-mail:wangyuehu@mail.kib.ac.cn;Chun-Lin Long,e-mail:long@mail.kib.ac.cn;Yi Kong,e-mail:yikong668@163.com
基金资助:
This work was funded by the Ministry of Science&Technology of China (2012FY110300);the National Natural Science Foundation of China (3116140345),and the Minzu University of China (YLDX01013,2015MDTD16C)

Neolignans from Selaginella moellendorffii

Jing-Xian Zhuo¹, Yue-Hu Wang¹, Xing-Li Su², Ren-Qiang Mei¹, Jun Yang¹, Yi Kong², Chun-Lin Long^1,3

1. Key Laboratory of Economic Plants and Biotechnology, and Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2. School of Life Science & Technology, China Pharmaceutical University, Nanjing 210009, China;
3. College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China

Received:2016-02-05 Revised:2016-03-20 Online:2016-06-24 Published:2018-02-08
Supported by:
This work was funded by the Ministry of Science&Technology of China (2012FY110300);the National Natural Science Foundation of China (3116140345),and the Minzu University of China (YLDX01013,2015MDTD16C)

摘要/Abstract

摘要： Two new neolignans selaginellol (1) and selaginellol 4'-O-b-D-glucopyranoside (2), together with seven known compounds (3-9), were isolated from the whole plant of Selaginella moellendorffii. The structures of the new isolates were determined through spectroscopic data analysis. Compounds 1-9, as well as compounds 10-18 previously isolated from the species, were measured for the activity against platelet aggregation induced by ADP or collagen. Three neoligans (8, 11, and 12), one flavanone (14), and one alkaloid (16) showed inhibitory activity against ADP-or collagen-induced platelet aggregation as compared with tirofiban. The dihydrobenzofuran neolignans (8, 11, and 12) are more potent than the benzofuran neolignan (13) and other types of neolignans (1-7). Glucosidation of the dihydrobenzofuran neolignans (11 and 12) is helpful for the activity.

关键词: Selaginellaceae, Selaginella moellendorffii, Lignans, Antiplatelet

Abstract: Two new neolignans selaginellol (1) and selaginellol 4'-O-b-D-glucopyranoside (2), together with seven known compounds (3-9), were isolated from the whole plant of Selaginella moellendorffii. The structures of the new isolates were determined through spectroscopic data analysis. Compounds 1-9, as well as compounds 10-18 previously isolated from the species, were measured for the activity against platelet aggregation induced by ADP or collagen. Three neoligans (8, 11, and 12), one flavanone (14), and one alkaloid (16) showed inhibitory activity against ADP-or collagen-induced platelet aggregation as compared with tirofiban. The dihydrobenzofuran neolignans (8, 11, and 12) are more potent than the benzofuran neolignan (13) and other types of neolignans (1-7). Glucosidation of the dihydrobenzofuran neolignans (11 and 12) is helpful for the activity.

Key words: Selaginellaceae, Selaginella moellendorffii, Lignans, Antiplatelet

Jing-Xian Zhuo, Yue-Hu Wang, Xing-Li Su, Ren-Qiang Mei, Jun Yang, Yi Kong, Chun-Lin Long. Neolignans from Selaginella moellendorffii[J]. 应用天然产物, 2016, 6(3): 161-166.

Jing-Xian Zhuo, Yue-Hu Wang, Xing-Li Su, Ren-Qiang Mei, Jun Yang, Yi Kong, Chun-Lin Long. Neolignans from Selaginella moellendorffii[J]. Natural Products and Bioprospecting, 2016, 6(3): 161-166.

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Neolignans from Selaginella moellendorffii

Neolignans from Selaginella moellendorffii

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