Compounds from Agathis dammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others

doi:10.1007/s13659-024-00440-4

应用天然产物 ›› 2024, Vol. 14 ›› Issue (3): 23-23.DOI: 10.1007/s13659-024-00440-4

Compounds from Agathis dammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others

Zhe-Wei Yu^1,2, Bang-Ping Cai³, Su-Zhi Xie⁴, Yi Zhang¹, Wen-Hui Wang¹, Shun-Zhi Liu¹, Yan-Lin Bin¹, Qi Chen¹, Mei-Juan Fang¹, Rong Qi², Ming-Yu Li¹, Ying-Kun Qiu¹

1 School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China;
2 School of Basic Medical Sciences, Peking University, Beijing 100191, China;
3 Xiamen Botanical Garden, Xiamen 361003, Fujian, China;
4 Xiamen Medical College Affiliated Haicang Hospital, Xiamen 361026, China

收稿日期:2023-12-05 发布日期:2024-06-14
通讯作者: Ming-Yu Li,E-mail:limingyu@xmu.edu.cn;Ying-Kun Qiu,E-mail:qyk@xmu.edu.cn
基金资助:
This work was financially supported by Project XWZY-2023-0303 supported by Traditional Chinese Medicine Foundation of Xiamen.

Compounds from Agathis dammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others

Zhe-Wei Yu^1,2, Bang-Ping Cai³, Su-Zhi Xie⁴, Yi Zhang¹, Wen-Hui Wang¹, Shun-Zhi Liu¹, Yan-Lin Bin¹, Qi Chen¹, Mei-Juan Fang¹, Rong Qi², Ming-Yu Li¹, Ying-Kun Qiu¹

1 School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China;
2 School of Basic Medical Sciences, Peking University, Beijing 100191, China;
3 Xiamen Botanical Garden, Xiamen 361003, Fujian, China;
4 Xiamen Medical College Affiliated Haicang Hospital, Xiamen 361026, China

Received:2023-12-05 Published:2024-06-14
Contact: Ming-Yu Li,E-mail:limingyu@xmu.edu.cn;Ying-Kun Qiu,E-mail:qyk@xmu.edu.cn
Supported by:
This work was financially supported by Project XWZY-2023-0303 supported by Traditional Chinese Medicine Foundation of Xiamen.

摘要/Abstract

摘要： In this study, two new kaurane diterpenes (16, 17), together with 12 lignans (1–12), a triterpene (15), and two other compounds (13, 14) were isolated from the woods of Agathis dammara. The structure of the new compound was determined by HR ESIMS and 1D/2D NMR spectroscopy, and its absolute configuration was determined by electronic circular dichroism (ECD) exciton chirality method. Compounds 5, 11, 14 exhibit significant hypoglycaemic activity in zebrafish, and their mechanism of action is to enhance glucose uptake in zebrafish.

关键词: Agathis dammara, Lignans, Terpenes, Hypoglycaemic, Glucose uptake

Abstract: In this study, two new kaurane diterpenes (16, 17), together with 12 lignans (1–12), a triterpene (15), and two other compounds (13, 14) were isolated from the woods of Agathis dammara. The structure of the new compound was determined by HR ESIMS and 1D/2D NMR spectroscopy, and its absolute configuration was determined by electronic circular dichroism (ECD) exciton chirality method. Compounds 5, 11, 14 exhibit significant hypoglycaemic activity in zebrafish, and their mechanism of action is to enhance glucose uptake in zebrafish.

Key words: Agathis dammara, Lignans, Terpenes, Hypoglycaemic, Glucose uptake

Zhe-Wei Yu, Bang-Ping Cai, Su-Zhi Xie, Yi Zhang, Wen-Hui Wang, Shun-Zhi Liu, Yan-Lin Bin, Qi Chen, Mei-Juan Fang, Rong Qi, Ming-Yu Li, Ying-Kun Qiu. Compounds from Agathis dammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others[J]. 应用天然产物, 2024, 14(3): 23-23.

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Compounds from Agathis dammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others

Compounds from Agathis dammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others

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