Artemyrianins A-G from Artemisia myriantha and Their Cytotoxicity Against HepG2 Cells

doi:10.1007/s13659-020-00255-z

应用天然产物 ›› 2020, Vol. 10 ›› Issue (4): 251-260.DOI: 10.1007/s13659-020-00255-z

Artemyrianins A-G from Artemisia myriantha and Their Cytotoxicity Against HepG2 Cells

Shuang Tang^1,2, Yun-Bao Ma¹, Chang-An Geng¹, Cheng Shen^1,2, Tian-Ze Li¹, Xue-Mei Zhang¹, Li-Hua Su^1,2, Zhen Gao^1,2, Jing Hu¹, Ji-Jun Chen^1,2

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

收稿日期:2020-04-27 修回日期:2020-06-17 出版日期:2020-08-24 发布日期:2020-08-19
通讯作者: Ji-Jun Chen
基金资助:
This work was financially supported by the Yunnan Wanren Project (YNWR-KJLJ-2019-002), the Program of Yunling Scholarship, the Reserve Talents of Young and Middle-aged Academic and Technical Leaders in Yunnan Province, and the Youth Innovation Promotion Association, CAS (2013252).

Artemyrianins A-G from Artemisia myriantha and Their Cytotoxicity Against HepG2 Cells

Shuang Tang^1,2, Yun-Bao Ma¹, Chang-An Geng¹, Cheng Shen^1,2, Tian-Ze Li¹, Xue-Mei Zhang¹, Li-Hua Su^1,2, Zhen Gao^1,2, Jing Hu¹, Ji-Jun Chen^1,2

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

Received:2020-04-27 Revised:2020-06-17 Online:2020-08-24 Published:2020-08-19
Contact: Ji-Jun Chen
Supported by:
This work was financially supported by the Yunnan Wanren Project (YNWR-KJLJ-2019-002), the Program of Yunling Scholarship, the Reserve Talents of Young and Middle-aged Academic and Technical Leaders in Yunnan Province, and the Youth Innovation Promotion Association, CAS (2013252).

摘要/Abstract

摘要： Four new sesquiterpenoids, artemyrianins A-D (1-4), and three new norlignans, artemyrianins E-G (5-7), together with five known compounds (8-12), were isolated from the aerial parts of Artemisia myriantha (Asteraceae). The new compounds were established by spectroscopic data analyses (HRMS, IR, 1D and 2D NMR), and their absolute configurations were confirmed by the single-crystal X-ray diffraction or ECD calculations. The isolates showed cytotoxicity against HepG2 cells with IC₅₀ values ranging from 33.3 to 145.2 μM.

关键词: Artemisia myriantha, Artemyrianins A-G, Sesquiterpenoids, Norlignans, Cytotoxicity, HepG2 cells

Abstract: Four new sesquiterpenoids, artemyrianins A-D (1-4), and three new norlignans, artemyrianins E-G (5-7), together with five known compounds (8-12), were isolated from the aerial parts of Artemisia myriantha (Asteraceae). The new compounds were established by spectroscopic data analyses (HRMS, IR, 1D and 2D NMR), and their absolute configurations were confirmed by the single-crystal X-ray diffraction or ECD calculations. The isolates showed cytotoxicity against HepG2 cells with IC₅₀ values ranging from 33.3 to 145.2 μM.

Key words: Artemisia myriantha, Artemyrianins A-G, Sesquiterpenoids, Norlignans, Cytotoxicity, HepG2 cells

Shuang Tang, Yun-Bao Ma, Chang-An Geng, Cheng Shen, Tian-Ze Li, Xue-Mei Zhang, Li-Hua Su, Zhen Gao, Jing Hu, Ji-Jun Chen. Artemyrianins A-G from Artemisia myriantha and Their Cytotoxicity Against HepG2 Cells[J]. 应用天然产物, 2020, 10(4): 251-260.

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Artemyrianins A-G from Artemisia myriantha and Their Cytotoxicity Against HepG2 Cells

Artemyrianins A-G from Artemisia myriantha and Their Cytotoxicity Against HepG2 Cells

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