A New Antimalarial Noreudesmane Sesquiterpenoid from Dobinea delavayi

doi:10.1007/s13659-020-00234-4

应用天然产物 ›› 2020, Vol. 10 ›› Issue (2): 101-104.DOI: 10.1007/s13659-020-00234-4

• ORIGINAL ARTICLES • 上一篇下一篇

A New Antimalarial Noreudesmane Sesquiterpenoid from Dobinea delavayi

Xiu-Rong Wu^1,2, Yi Shen^1,2, Shu-Jun Cui^1,2, Xiao-Lei Luo^1,2, Chao-Jiang Xiao², Bei Jiang¹

1 Institute of Materia Medica, Dali University, Xueren Road 2, Dali 671000, People's Republic of China;
2 College of Pharmacy and Chemistry, Dali University, Xueren Road 2, Dali 671000, People's Republic of China

收稿日期:2020-01-02 修回日期:2020-02-10 出版日期:2020-04-24 发布日期:2020-05-06
通讯作者: Chao-Jiang Xiao, Bei Jiang
基金资助:
This work was financially supported by the National Natural Science Foundation of China (Nos. 81960637 and 81460532), and the Innovation Team Project of Dali University for the Development and Utilization of Characteristic Medicinal Plants in Western Yunnan & Bai Nationality Medicines (No. ZKLX2019106).

A New Antimalarial Noreudesmane Sesquiterpenoid from Dobinea delavayi

Xiu-Rong Wu^1,2, Yi Shen^1,2, Shu-Jun Cui^1,2, Xiao-Lei Luo^1,2, Chao-Jiang Xiao², Bei Jiang¹

1 Institute of Materia Medica, Dali University, Xueren Road 2, Dali 671000, People's Republic of China;
2 College of Pharmacy and Chemistry, Dali University, Xueren Road 2, Dali 671000, People's Republic of China

Received:2020-01-02 Revised:2020-02-10 Online:2020-04-24 Published:2020-05-06
Contact: Chao-Jiang Xiao, Bei Jiang
Supported by:
This work was financially supported by the National Natural Science Foundation of China (Nos. 81960637 and 81460532), and the Innovation Team Project of Dali University for the Development and Utilization of Characteristic Medicinal Plants in Western Yunnan & Bai Nationality Medicines (No. ZKLX2019106).

摘要/Abstract

摘要： One previously undescribed angeloylated noreudesmane sesquiterpenoid, dobinin O (1), along with four known eudesmane sesquiterpenoids (2-5) were isolated from the peeled roots of Dobinea delavayi. Their structures were elucidated by extensive spectroscopic data analyses. In addition, compound 1 exhibited moderate antimalarial activity against Plasmodium yoelii BY265RFP with the inhibition ratio of 17.8±13.3% at the dose of 30 mg/kg/day.

关键词: Dobinea delavayi, Anacardiaceae, Noreudesmane sesquiterpenoid, Antimalarial activity

Abstract: One previously undescribed angeloylated noreudesmane sesquiterpenoid, dobinin O (1), along with four known eudesmane sesquiterpenoids (2-5) were isolated from the peeled roots of Dobinea delavayi. Their structures were elucidated by extensive spectroscopic data analyses. In addition, compound 1 exhibited moderate antimalarial activity against Plasmodium yoelii BY265RFP with the inhibition ratio of 17.8±13.3% at the dose of 30 mg/kg/day.

Key words: Dobinea delavayi, Anacardiaceae, Noreudesmane sesquiterpenoid, Antimalarial activity

Xiu-Rong Wu, Yi Shen, Shu-Jun Cui, Xiao-Lei Luo, Chao-Jiang Xiao, Bei Jiang. A New Antimalarial Noreudesmane Sesquiterpenoid from Dobinea delavayi[J]. 应用天然产物, 2020, 10(2): 101-104.

Xiu-Rong Wu, Yi Shen, Shu-Jun Cui, Xiao-Lei Luo, Chao-Jiang Xiao, Bei Jiang. A New Antimalarial Noreudesmane Sesquiterpenoid from Dobinea delavayi[J]. Natural Products and Bioprospecting, 2020, 10(2): 101-104.

A New Antimalarial Noreudesmane Sesquiterpenoid from Dobinea delavayi

A New Antimalarial Noreudesmane Sesquiterpenoid from Dobinea delavayi

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 1

编辑推荐

Metrics

本文评价