Partial Synthesis of Crassicauline A from Yunaconitine

doi:10.1007/s13659-020-00238-0

应用天然产物 ›› 2020, Vol. 10 ›› Issue (2): 105-108.DOI: 10.1007/s13659-020-00238-0

• ORIGINAL ARTICLES • 上一篇

Partial Synthesis of Crassicauline A from Yunaconitine

Rong-Ping Zhang^1,2, Yan-Jun Lin², Hao-Fei Yu², Si-Ying Chen³, Jun Zhou³

1 Yunnan University of Chinese Medicine, Kunming, China;
2 Kunming Medical University, Kunming, China;
3 Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China

收稿日期:2020-01-10 修回日期:2020-03-19 出版日期:2020-04-24 发布日期:2020-05-06
通讯作者: Jun Zhou
基金资助:
The authors appreciate the members at Kunming Institute of Botany, Chinese Academy of Science for measuring the spectroscopic data and the members of Yunnan toxic medicinal plants research team for picking and treatment of pharmaceutical raw materials. This work was supported by "YunLing Scholars" project (2020HC008).

Partial Synthesis of Crassicauline A from Yunaconitine

Rong-Ping Zhang^1,2, Yan-Jun Lin², Hao-Fei Yu², Si-Ying Chen³, Jun Zhou³

1 Yunnan University of Chinese Medicine, Kunming, China;
2 Kunming Medical University, Kunming, China;
3 Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China

Received:2020-01-10 Revised:2020-03-19 Online:2020-04-24 Published:2020-05-06
Contact: Jun Zhou
Supported by:
The authors appreciate the members at Kunming Institute of Botany, Chinese Academy of Science for measuring the spectroscopic data and the members of Yunnan toxic medicinal plants research team for picking and treatment of pharmaceutical raw materials. This work was supported by "YunLing Scholars" project (2020HC008).

摘要/Abstract

摘要： Both Aconitum hemsleyanum and Aconitum geniculatun have abundant contents of yunaconitine (1). Yunaconitine (1) has similar skeleton to crassicauline A (3); the only difference between them is that 1 contains a α-hydroxyl group at C-3. Our team attempts to convert 1 into 3 because 3 owns pharmacological activity. There are two steps to achieve the transformation above:firstly, use dehydration reaction to transform yunaconitine (1) into dehydroyunaconitine (2); secondly, use hydrogen reduction to acquire crassicauline A (3). Compared with other methods, this one below is more suitable for production application and more concise; moreover, the cost is lower with higher yield.

关键词: Diterpenoid alkaloids, Yunaconitine, Crassicauline A

Abstract: Both Aconitum hemsleyanum and Aconitum geniculatun have abundant contents of yunaconitine (1). Yunaconitine (1) has similar skeleton to crassicauline A (3); the only difference between them is that 1 contains a α-hydroxyl group at C-3. Our team attempts to convert 1 into 3 because 3 owns pharmacological activity. There are two steps to achieve the transformation above:firstly, use dehydration reaction to transform yunaconitine (1) into dehydroyunaconitine (2); secondly, use hydrogen reduction to acquire crassicauline A (3). Compared with other methods, this one below is more suitable for production application and more concise; moreover, the cost is lower with higher yield.

Key words: Diterpenoid alkaloids, Yunaconitine, Crassicauline A

Rong-Ping Zhang, Yan-Jun Lin, Hao-Fei Yu, Si-Ying Chen, Jun Zhou. Partial Synthesis of Crassicauline A from Yunaconitine[J]. 应用天然产物, 2020, 10(2): 105-108.

Rong-Ping Zhang, Yan-Jun Lin, Hao-Fei Yu, Si-Ying Chen, Jun Zhou. Partial Synthesis of Crassicauline A from Yunaconitine[J]. Natural Products and Bioprospecting, 2020, 10(2): 105-108.

Partial Synthesis of Crassicauline A from Yunaconitine

Partial Synthesis of Crassicauline A from Yunaconitine

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