Cytotoxic Cycloartane Triterpenoid Saponins from the Rhizomes of Cimicifuga foetida

doi:10.1007/s13659-019-0214-1

应用天然产物 ›› 2019, Vol. 9 ›› Issue (4): 303-310.DOI: 10.1007/s13659-019-0214-1

• ORIGINAL ARTICLES • 上一篇

Cytotoxic Cycloartane Triterpenoid Saponins from the Rhizomes of Cimicifuga foetida

Jing Lu^1,2, Xing-Rong Peng¹, Da-Shan Li¹, Qiang-Qiang Shi^1,2, Ming-Hua Qiu^1,2,3

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences (CAS), Kunming 650204, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, China;
3 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132 LanHei Road, Kunming 650201, Yunnan, People's Republic of China

收稿日期:2019-04-07 修回日期:2019-06-05 出版日期:2019-08-24 发布日期:2019-08-09
通讯作者: Ming-Hua Qiu
基金资助:
This research work was financial supported by Programs of National Natural Science Foundation of China (Nos. 81803396 and U1132604), Autonomous Deployment Project (KIB2017010) of Kunming Institute of Botany, CAS, as well as The Major Program of CAS (No. KSZD-EW-Z-004-01).

Cytotoxic Cycloartane Triterpenoid Saponins from the Rhizomes of Cimicifuga foetida

Jing Lu^1,2, Xing-Rong Peng¹, Da-Shan Li¹, Qiang-Qiang Shi^1,2, Ming-Hua Qiu^1,2,3

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences (CAS), Kunming 650204, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, China;
3 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132 LanHei Road, Kunming 650201, Yunnan, People's Republic of China

Received:2019-04-07 Revised:2019-06-05 Online:2019-08-24 Published:2019-08-09
Contact: Ming-Hua Qiu
Supported by:
This research work was financial supported by Programs of National Natural Science Foundation of China (Nos. 81803396 and U1132604), Autonomous Deployment Project (KIB2017010) of Kunming Institute of Botany, CAS, as well as The Major Program of CAS (No. KSZD-EW-Z-004-01).

摘要/Abstract

摘要： To enrich the bioactive cycloartane triterpenoid glycoside named actein and find out more cytotoxic cycloartane triterpenes, a phytochemical study of Cimicifuga foetida was conducted. 113 g (0.17%) actein was purified by recrystallization while eight cycloartane-type triterpenes (1-8) were isolated from the mother liquid. The chemical structures of new compounds (1-4) were elucidated by 1D and 2D NMR and HRESIMS spectroscopic analyses. Moreover, new compounds showed moderate and broad-spectrum cytotoxicity against 5 human cancer cell lines with IC₅₀ values ranging from 4.02 to 15.80 μM.

关键词: Cimicifuga foetida, Cycloartane triterpenoid saponins, Cytotoxic activity

Abstract: To enrich the bioactive cycloartane triterpenoid glycoside named actein and find out more cytotoxic cycloartane triterpenes, a phytochemical study of Cimicifuga foetida was conducted. 113 g (0.17%) actein was purified by recrystallization while eight cycloartane-type triterpenes (1-8) were isolated from the mother liquid. The chemical structures of new compounds (1-4) were elucidated by 1D and 2D NMR and HRESIMS spectroscopic analyses. Moreover, new compounds showed moderate and broad-spectrum cytotoxicity against 5 human cancer cell lines with IC₅₀ values ranging from 4.02 to 15.80 μM.

Key words: Cimicifuga foetida, Cycloartane triterpenoid saponins, Cytotoxic activity

Jing Lu, Xing-Rong Peng, Da-Shan Li, Qiang-Qiang Shi, Ming-Hua Qiu. Cytotoxic Cycloartane Triterpenoid Saponins from the Rhizomes of Cimicifuga foetida[J]. 应用天然产物, 2019, 9(4): 303-310.

Jing Lu, Xing-Rong Peng, Da-Shan Li, Qiang-Qiang Shi, Ming-Hua Qiu. Cytotoxic Cycloartane Triterpenoid Saponins from the Rhizomes of Cimicifuga foetida[J]. Natural Products and Bioprospecting, 2019, 9(4): 303-310.

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Cytotoxic Cycloartane Triterpenoid Saponins from the Rhizomes of Cimicifuga foetida

Cytotoxic Cycloartane Triterpenoid Saponins from the Rhizomes of Cimicifuga foetida

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