Tangutidines A-C, Three Amphoteric Diterpene Alkaloids from Aconitum tanguticum

doi:10.1007/s13659-021-00310-3

应用天然产物 ›› 2021, Vol. 11 ›› Issue (4): 459-464.DOI: 10.1007/s13659-021-00310-3

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Tangutidines A-C, Three Amphoteric Diterpene Alkaloids from Aconitum tanguticum

Hao-Yi Li^1,2, Bing-Chao Yan¹, Li-Xin Wei³, Han-Dong Sun¹, Pema-Tenzin Puno¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3 Qinghai Provincial Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, People's Republic of China

收稿日期:2021-03-22 接受日期:2021-05-06 出版日期:2021-08-24 发布日期:2021-07-30
通讯作者: Han-Dong Sun, Pema-Tenzin Puno
基金资助:
This project was supported financially by the Second Tibetan Plateau Scientific Expedition and Research (STEP) program (2019QZKK0502) and the National Natural Science Foundation of China (No. 81673329). Authors are grateful for Dr. Ming Zhang from northwest institute of plateau biology, Chinese Academy of Sciences, for the assistance for obtaining plant materials.

Tangutidines A-C, Three Amphoteric Diterpene Alkaloids from Aconitum tanguticum

Hao-Yi Li^1,2, Bing-Chao Yan¹, Li-Xin Wei³, Han-Dong Sun¹, Pema-Tenzin Puno¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3 Qinghai Provincial Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, People's Republic of China

Received:2021-03-22 Accepted:2021-05-06 Online:2021-08-24 Published:2021-07-30
Contact: Han-Dong Sun, Pema-Tenzin Puno
Supported by:
This project was supported financially by the Second Tibetan Plateau Scientific Expedition and Research (STEP) program (2019QZKK0502) and the National Natural Science Foundation of China (No. 81673329). Authors are grateful for Dr. Ming Zhang from northwest institute of plateau biology, Chinese Academy of Sciences, for the assistance for obtaining plant materials.

摘要/Abstract

摘要： Three new diterpene alkaloids, tangutidines A-C (1-3), and four known alkaloids (4-7) were isolated from the whole plant of Aconitum tanguticum, from which amphoteric diterpene alkaloids (1-3) were obtained for the first time. The structures of 1-3 were elucidated by detailed interpretation of spectroscopic data, including MS and NMR data. All of them were evaluated for their cytotoxic activities.

关键词: Amphoteric diterpene alkaloids, Tangutidine, Cytotoxic activity, Aconitum tanguticum

Abstract: Three new diterpene alkaloids, tangutidines A-C (1-3), and four known alkaloids (4-7) were isolated from the whole plant of Aconitum tanguticum, from which amphoteric diterpene alkaloids (1-3) were obtained for the first time. The structures of 1-3 were elucidated by detailed interpretation of spectroscopic data, including MS and NMR data. All of them were evaluated for their cytotoxic activities.

Key words: Aconitum tanguticum, Amphoteric diterpene alkaloids, Tangutidine, Cytotoxic activity

Hao-Yi Li, Bing-Chao Yan, Li-Xin Wei, Han-Dong Sun, Pema-Tenzin Puno. Tangutidines A-C, Three Amphoteric Diterpene Alkaloids from Aconitum tanguticum[J]. 应用天然产物, 2021, 11(4): 459-464.

Hao-Yi Li, Bing-Chao Yan, Li-Xin Wei, Han-Dong Sun, Pema-Tenzin Puno. Tangutidines A-C, Three Amphoteric Diterpene Alkaloids from Aconitum tanguticum[J]. Natural Products and Bioprospecting, 2021, 11(4): 459-464.

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Tangutidines A-C, Three Amphoteric Diterpene Alkaloids from Aconitum tanguticum

Tangutidines A-C, Three Amphoteric Diterpene Alkaloids from Aconitum tanguticum

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