Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla

doi:10.1007/s13659-015-0074-2

应用天然产物 ›› 2015, Vol. 5 ›› Issue (5): 247-253.DOI: 10.1007/s13659-015-0074-2

• Original article • 上一篇下一篇

Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla

Yuan Gao, Dong-Sheng Zhou, Ping Hai, Yan Li, Fei Wang

1. BioBioPha Co., Ltd., Kunming 650201, People's Republic of China;
2. Department of Chemical Engineering, Yibin University, Yibin 644000, People's Republic of China

收稿日期:2015-09-02 修回日期:2015-09-24 出版日期:2015-10-24 发布日期:2018-02-11
通讯作者: Fei Wang,e-mail:f.wang@mail.biobiopha.com
基金资助:
This work was financially supported by "Largescale Compound Library" Project of National Development and Reform Commission of China.

Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla

Yuan Gao, Dong-Sheng Zhou, Ping Hai, Yan Li, Fei Wang

1. BioBioPha Co., Ltd., Kunming 650201, People's Republic of China;
2. Department of Chemical Engineering, Yibin University, Yibin 644000, People's Republic of China

Received:2015-09-02 Revised:2015-09-24 Online:2015-10-24 Published:2018-02-11
Supported by:
This work was financially supported by "Largescale Compound Library" Project of National Development and Reform Commission of China.

摘要/Abstract

摘要： Five new hybrid monoterpenoid indole alkaloids bearing an unusual 2, 2-dimethyl-4-oxopiperidin-6-yl moiety, namely rauvotetraphyllines F-H(1, 3, 4), 17-epi-rauvotetraphylline F(2) and 21-epi-rauvotetraphylline H(5), were isolated from the aerial parts of Rauvolfia tetraphylla. Their structures were established by extensive spectroscopic analysis. The new alkaloids were evaluated for their cytotoxicity in vitro against five human cancer cell lines.

关键词: Rauvolfia tetraphylla, Monoterpenoid indole alkaloid, Rauvotetraphylline

Abstract: Five new hybrid monoterpenoid indole alkaloids bearing an unusual 2, 2-dimethyl-4-oxopiperidin-6-yl moiety, namely rauvotetraphyllines F-H(1, 3, 4), 17-epi-rauvotetraphylline F(2) and 21-epi-rauvotetraphylline H(5), were isolated from the aerial parts of Rauvolfia tetraphylla. Their structures were established by extensive spectroscopic analysis. The new alkaloids were evaluated for their cytotoxicity in vitro against five human cancer cell lines.

Key words: Rauvolfia tetraphylla, Monoterpenoid indole alkaloid, Rauvotetraphylline

Yuan Gao, Dong-Sheng Zhou, Ping Hai, Yan Li, Fei Wang. Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla[J]. 应用天然产物, 2015, 5(5): 247-253.

Yuan Gao, Dong-Sheng Zhou, Ping Hai, Yan Li, Fei Wang. Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla[J]. Natural Products and Bioprospecting, 2015, 5(5): 247-253.

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Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla

Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla

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