Effects of Traditional Chinese Medicinal Plants on Antiinsulin Resistance Bioactivity of DXMS-Induced Insulin Resistant HepG2 Cells

doi:10.1007/s13659-014-0028-0

应用天然产物 ›› 2014, Vol. 4 ›› Issue (4): 197-206.DOI: 10.1007/s13659-014-0028-0

• Original article • 下一篇

Effects of Traditional Chinese Medicinal Plants on Antiinsulin Resistance Bioactivity of DXMS-Induced Insulin Resistant HepG2 Cells

Jun-Zeng Ma¹, Li-Xin Yang^1,2, Xiao-Ling Shen³, Ji-Huan Qin³, Li-Lan Deng⁴, Selena Ahmed^2,5, Hong-Xi Xu⁶, Da-Yuan Xue², Jiang-Xia Ye⁴, Gang Xu¹

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2. College of Life and Environmental Science, Minzu University of China, 27 ZhongGuanCun South Avenue, Beijing 100086, China;
3. Laboratory of Chinese Herbal Drug Discovery, Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, People's Republic of China;
4. Southwest Forestry University, Kunming 650224, People's Republic of China;
5. Sustainable Food and Bioenergy Systems Program, Department of Health and Human Development, Montana State University, Bozeman, MT 59717, USA;
6. Shanghai University of Traditional Chinese Medicine, Shanghai 201203, People's Republic of China

收稿日期:2014-05-21 修回日期:2014-06-16 出版日期:2014-08-24 发布日期:2018-02-11
通讯作者: Da-Yuan Xue,e-mail:xlshen66@126.com;Da-Yuan Xue,e-mail:xuedayuan@hotmail.com;Gang Xu,e-mail:xugang008@mail.kib.ac.cn
基金资助:
The work was financially supported by China National Major Projects(2009ZX09103-436) and 973 Program(2011CB915503) of Science and Technology of P. R. China, the reservation-talent project of Yunnan Province(2009CI073), the foundation of study abroad returnees from Ministry of Personnel for financial support(Ms. Li-Xin Yang), and the foundations from CAS(Dr. Gang Xu).

Effects of Traditional Chinese Medicinal Plants on Antiinsulin Resistance Bioactivity of DXMS-Induced Insulin Resistant HepG2 Cells

Jun-Zeng Ma¹, Li-Xin Yang^1,2, Xiao-Ling Shen³, Ji-Huan Qin³, Li-Lan Deng⁴, Selena Ahmed^2,5, Hong-Xi Xu⁶, Da-Yuan Xue², Jiang-Xia Ye⁴, Gang Xu¹

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2. College of Life and Environmental Science, Minzu University of China, 27 ZhongGuanCun South Avenue, Beijing 100086, China;
3. Laboratory of Chinese Herbal Drug Discovery, Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, People's Republic of China;
4. Southwest Forestry University, Kunming 650224, People's Republic of China;
5. Sustainable Food and Bioenergy Systems Program, Department of Health and Human Development, Montana State University, Bozeman, MT 59717, USA;
6. Shanghai University of Traditional Chinese Medicine, Shanghai 201203, People's Republic of China

Received:2014-05-21 Revised:2014-06-16 Online:2014-08-24 Published:2018-02-11
Supported by:
The work was financially supported by China National Major Projects(2009ZX09103-436) and 973 Program(2011CB915503) of Science and Technology of P. R. China, the reservation-talent project of Yunnan Province(2009CI073), the foundation of study abroad returnees from Ministry of Personnel for financial support(Ms. Li-Xin Yang), and the foundations from CAS(Dr. Gang Xu).

摘要/Abstract

摘要： Medicinal plants have a long history of use in China to treat diabetic symptoms. Ancient Chinese medical manuscripts and ethnobotanical surveys document plant remedies that continue to be actively used in China for the treatment of diabetic symptoms. Based on a systematic ancient Chinese medical manuscripts review in combination with ethnobotanical survey, 16 medicinal plants for the traditional treatment of diabetic symptoms were identified for the evaluation of anti-insulin resistance bioactivity. The biological activity of 16 medicinal plants was tested on dexamethasone(DXMS)-induced insulin resistant HepG2 cells. The result shows that 11 of the 16 medicinal plants enhanced glucose uptake of DXMS-induced insulin resistant HepG2 cells, thereby demonstrating their ability to increase insulin sensitivity, other five medicinal plants including Astragalus membranaceus were found ineffective. The study shows that ancient Chinese medical manuscripts and ethnobotanical surveys on plants for the prevention and treatment of diabetic symptoms provide a promising knowledge base for drug discovery to mitigate the global diabetes epidemic.

关键词: Traditional medicinal plants, Diabetes, Anti-insulin resistance bioactivity, DXMS-induced insulin resistant HepG2 cells

Abstract: Medicinal plants have a long history of use in China to treat diabetic symptoms. Ancient Chinese medical manuscripts and ethnobotanical surveys document plant remedies that continue to be actively used in China for the treatment of diabetic symptoms. Based on a systematic ancient Chinese medical manuscripts review in combination with ethnobotanical survey, 16 medicinal plants for the traditional treatment of diabetic symptoms were identified for the evaluation of anti-insulin resistance bioactivity. The biological activity of 16 medicinal plants was tested on dexamethasone(DXMS)-induced insulin resistant HepG2 cells. The result shows that 11 of the 16 medicinal plants enhanced glucose uptake of DXMS-induced insulin resistant HepG2 cells, thereby demonstrating their ability to increase insulin sensitivity, other five medicinal plants including Astragalus membranaceus were found ineffective. The study shows that ancient Chinese medical manuscripts and ethnobotanical surveys on plants for the prevention and treatment of diabetic symptoms provide a promising knowledge base for drug discovery to mitigate the global diabetes epidemic.

Key words: Traditional medicinal plants, Diabetes, Anti-insulin resistance bioactivity, DXMS-induced insulin resistant HepG2 cells

Jun-Zeng Ma, Li-Xin Yang, Xiao-Ling Shen, Ji-Huan Qin, Li-Lan Deng, Selena Ahmed, Hong-Xi Xu, Da-Yuan Xue, Jiang-Xia Ye, Gang Xu. Effects of Traditional Chinese Medicinal Plants on Antiinsulin Resistance Bioactivity of DXMS-Induced Insulin Resistant HepG2 Cells[J]. 应用天然产物, 2014, 4(4): 197-206.

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Effects of Traditional Chinese Medicinal Plants on Antiinsulin Resistance Bioactivity of DXMS-Induced Insulin Resistant HepG2 Cells

Effects of Traditional Chinese Medicinal Plants on Antiinsulin Resistance Bioactivity of DXMS-Induced Insulin Resistant HepG2 Cells

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