Utilization of Swertia chirayita Plant Extracts for Management of Diabetes and Associated Disorders: Present Status, Future Prospects and Limitations

doi:10.1007/s13659-020-00277-7

应用天然产物 ›› 2020, Vol. 10 ›› Issue (6): 431-443.DOI: 10.1007/s13659-020-00277-7

Utilization of Swertia chirayita Plant Extracts for Management of Diabetes and Associated Disorders: Present Status, Future Prospects and Limitations

Pinaki Dey¹, Joginder Singh², Jagadish Kumar Suluvoy³, Kevin Joseph Dilip⁴, Jayato Nayak⁵

1 Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore, Tamil Nadu 641114, India;
2 Department of Microbiology, Lovely Professional University, Phagwara, Punjab 144411, India;
3 Biotechnology Department, Vignan Foundation for Science Technology and Research, Guntur, Andhra Pradesh 522213, India;
4 National Dong Hwa University, Department of Life Sciences, Hualien, China;
5 Department of Chemical Engineering, VSB Engineering College, Karur, Tamil Nadu 639111, India

收稿日期:2020-07-21 修回日期:2020-10-05 出版日期:2020-12-24 发布日期:2020-12-24
通讯作者: Pinaki Dey
基金资助:
Authors are thankful to sort term research Grant provided by KITS for doing further research work related to the review topic.

Utilization of Swertia chirayita Plant Extracts for Management of Diabetes and Associated Disorders: Present Status, Future Prospects and Limitations

Pinaki Dey¹, Joginder Singh², Jagadish Kumar Suluvoy³, Kevin Joseph Dilip⁴, Jayato Nayak⁵

1 Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore, Tamil Nadu 641114, India;
2 Department of Microbiology, Lovely Professional University, Phagwara, Punjab 144411, India;
3 Biotechnology Department, Vignan Foundation for Science Technology and Research, Guntur, Andhra Pradesh 522213, India;
4 National Dong Hwa University, Department of Life Sciences, Hualien, China;
5 Department of Chemical Engineering, VSB Engineering College, Karur, Tamil Nadu 639111, India

Received:2020-07-21 Revised:2020-10-05 Online:2020-12-24 Published:2020-12-24
Contact: Pinaki Dey
Supported by:
Authors are thankful to sort term research Grant provided by KITS for doing further research work related to the review topic.

摘要/Abstract

摘要： Diabetes mellitus is referred as common metabolic abnormalities characterized as hyperglycemia, mainly caused due to insufficient production of insulin at cellular level or/and defects in insulin action. Such an endocrine disorder is responsible for serious health problems and its worldwide prevalence is rapidly increasing. Common management of diabetes by oral administration of drugs without creating any side effects is still considered a challenging task and increasing cost of conventional medicine in developing countries is another matter of concern. To address these issues, traditional preparations of herbal plant extracts in the form of medicines already gained immense attention. Swertia chirayita is one among such plants which is known for its hypoglycemic potential. Numerous chemical constituents with promising pharmacological properties have been identified from such plant extracts but still, such compounds have not been well characterized, specifically against human application. Hence, more research efforts are necessitated to understand exact mechanism of such compounds and to develop overall safety of such plant formulations. Present review clearly represents antidiabetic properties of Swertia chirayita extract, strategies to be taken to strengthen its safety application on humans and biotechnological interventions that ensure conservation of such endangered species to promote its future application in modern medicine.

关键词: Swertia chirayita, Diabetes, Phytochemicals, Conservation

Abstract: Diabetes mellitus is referred as common metabolic abnormalities characterized as hyperglycemia, mainly caused due to insufficient production of insulin at cellular level or/and defects in insulin action. Such an endocrine disorder is responsible for serious health problems and its worldwide prevalence is rapidly increasing. Common management of diabetes by oral administration of drugs without creating any side effects is still considered a challenging task and increasing cost of conventional medicine in developing countries is another matter of concern. To address these issues, traditional preparations of herbal plant extracts in the form of medicines already gained immense attention. Swertia chirayita is one among such plants which is known for its hypoglycemic potential. Numerous chemical constituents with promising pharmacological properties have been identified from such plant extracts but still, such compounds have not been well characterized, specifically against human application. Hence, more research efforts are necessitated to understand exact mechanism of such compounds and to develop overall safety of such plant formulations. Present review clearly represents antidiabetic properties of Swertia chirayita extract, strategies to be taken to strengthen its safety application on humans and biotechnological interventions that ensure conservation of such endangered species to promote its future application in modern medicine.

Key words: Swertia chirayita, Diabetes, Phytochemicals, Conservation

Pinaki Dey, Joginder Singh, Jagadish Kumar Suluvoy, Kevin Joseph Dilip, Jayato Nayak. Utilization of Swertia chirayita Plant Extracts for Management of Diabetes and Associated Disorders: Present Status, Future Prospects and Limitations[J]. 应用天然产物, 2020, 10(6): 431-443.

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Utilization of Swertia chirayita Plant Extracts for Management of Diabetes and Associated Disorders: Present Status, Future Prospects and Limitations

Utilization of Swertia chirayita Plant Extracts for Management of Diabetes and Associated Disorders: Present Status, Future Prospects and Limitations

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