应用天然产物 ›› 2014, Vol. 4 ›› Issue (1): 47-51.DOI: 10.1007/s13659-014-0003-9
Ping Hai1, Shi-Zhen Wen1, Yan Li2, Yuan Gao1,2, Xian-Jun Jiang1, Fei Wang1,2
收稿日期:2013-11-26
修回日期:2014-01-12
出版日期:2014-02-24
发布日期:2018-02-11
通讯作者:
Fei Wang,e-mail:wangfei@mail.kib.ac.cn
基金资助:Ping Hai1, Shi-Zhen Wen1, Yan Li2, Yuan Gao1,2, Xian-Jun Jiang1, Fei Wang1,2
Received:2013-11-26
Revised:2014-01-12
Online:2014-02-24
Published:2018-02-11
Supported by:摘要： Three hitherto unknown taxane diterpenoids, namely baccatin VIII(1), baccatin IX(2), and baccatin X(3), along with 10 known analogues were isolated from an ethanolic extract of the twigs and leaves of Taxus yunnanensis. The new structures were characterized based on extensive spectroscopic analysis. Compounds 1 and 2 were tested for their in vitro cytotoxicity against five human tumor cell lines, and 1 exhibited inhibitory effects on HL-60 and MCF-7, with IC50 values of 3.44 and 9.67 μM, respectively.
Ping Hai, Shi-Zhen Wen, Yan Li, Yuan Gao, Xian-Jun Jiang, Fei Wang. New Taxane Diterpenoids from Taxus yunnanensis[J]. 应用天然产物, 2014, 4(1): 47-51.
Ping Hai, Shi-Zhen Wen, Yan Li, Yuan Gao, Xian-Jun Jiang, Fei Wang. New Taxane Diterpenoids from Taxus yunnanensis[J]. Natural Products and Bioprospecting, 2014, 4(1): 47-51.
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