Total synthesis of 1-oxomiltirone via Suzuki coupling

doi:10.1007/s13659-013-0034-7

应用天然产物 ›› 2013, Vol. 3 ›› Issue (3): 117-120.DOI: 10.1007/s13659-013-0034-7

• Short Communication • 上一篇

Total synthesis of 1-oxomiltirone via Suzuki coupling

Chun-Miao LI^a,c, Hui-Chun GENG^a,b, Ming-Ming LI^a, Gang XU^a, Tie-Jun LING^c, Hong-Bo QIN^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b University of Chinese Academy of Sciences, Beijing 100049, China;
c Key Laboratory of Tea Biochemistry and Biotechnology of Ministry of Education & Ministry of Agriculture, Anhui Agricultural University, Hefei 230036, China

收稿日期:2013-04-22 修回日期:2013-05-20 出版日期:2013-06-24 发布日期:2018-02-11
通讯作者: Hong-Bo QIN,E-mail:qinhongbo@mail.kib.ac.cn;Tie-Jun LING,E-mail:lingtj@ahau.edu.cn

Total synthesis of 1-oxomiltirone via Suzuki coupling

Chun-Miao LI^a,c, Hui-Chun GENG^a,b, Ming-Ming LI^a, Gang XU^a, Tie-Jun LING^c, Hong-Bo QIN^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b University of Chinese Academy of Sciences, Beijing 100049, China;
c Key Laboratory of Tea Biochemistry and Biotechnology of Ministry of Education & Ministry of Agriculture, Anhui Agricultural University, Hefei 230036, China

Received:2013-04-22 Revised:2013-05-20 Online:2013-06-24 Published:2018-02-11

摘要/Abstract

摘要： Abietane diterpenes and miltirone series have shown important activities and for medical purposes in order to achieve the total synthesis of 1-oxomiltrone 1 and miltirone 4, a versatile intermediate 6 was found. The compound 6 could be used as a precursor A-B-C rings with different oxidative degrees in selected abietane diterpenes when synthesized through high yield Suzuki reaction and subsequent cyclization, and total synthesis of 1-oxomiltirone (1) has been achieved.

关键词: total synthesis, Suzuki coupling, 1-oxomiltirone, abietane diterpenes, versatile intermediate

Abstract: Abietane diterpenes and miltirone series have shown important activities and for medical purposes in order to achieve the total synthesis of 1-oxomiltrone 1 and miltirone 4, a versatile intermediate 6 was found. The compound 6 could be used as a precursor A-B-C rings with different oxidative degrees in selected abietane diterpenes when synthesized through high yield Suzuki reaction and subsequent cyclization, and total synthesis of 1-oxomiltirone (1) has been achieved.

Key words: total synthesis, Suzuki coupling, 1-oxomiltirone, abietane diterpenes, versatile intermediate

Chun-Miao LI, Hui-Chun GENG, Ming-Ming LI, Gang XU, Tie-Jun LING, Hong-Bo QIN. Total synthesis of 1-oxomiltirone via Suzuki coupling[J]. 应用天然产物, 2013, 3(3): 117-120.

Chun-Miao LI, Hui-Chun GENG, Ming-Ming LI, Gang XU, Tie-Jun LING, Hong-Bo QIN. Total synthesis of 1-oxomiltirone via Suzuki coupling[J]. Natural Products and Bioprospecting, 2013, 3(3): 117-120.

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Total synthesis of 1-oxomiltirone via Suzuki coupling

Total synthesis of 1-oxomiltirone via Suzuki coupling

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