Chemical constituents from the aerial parts of Euphorbia sikkimensis and their bioactivities

doi:10.1007/s13659-013-0006-y

应用天然产物 ›› 2013, Vol. 3 ›› Issue (3): 112-116.DOI: 10.1007/s13659-013-0006-y

• Short Communication • 上一篇下一篇

Chemical constituents from the aerial parts of Euphorbia sikkimensis and their bioactivities

Da-Song YANG^a,b,c, Wei-Bing PENG^d, Zi-Lei LI^a,b,c, Xue WANG^d, Jian-Guo WEI^a,b,c, Ke-Chun LIU^d, Yong-Ping YANG^a,b,c, Xiao-Li LI^a,b,c

a Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Plant Germplasm and Genomics Center, the Germplasm Bank of Wild Species, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
c Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
d Biology Institute of Shandong Academy of Sciences, Jinan 250014, China

收稿日期:2013-01-22 修回日期:2013-03-28 出版日期:2013-06-24 发布日期:2018-02-11
通讯作者: Xiao-Li LI,E-mail:li_xiaoli11@mail.kib.ac.cn
基金资助:
This work was supported by the Basic Research Project of the Ministry of Science and Technology of China (2012FY110300), MOST grant (2008BAD98B06).

Chemical constituents from the aerial parts of Euphorbia sikkimensis and their bioactivities

Da-Song YANG^a,b,c, Wei-Bing PENG^d, Zi-Lei LI^a,b,c, Xue WANG^d, Jian-Guo WEI^a,b,c, Ke-Chun LIU^d, Yong-Ping YANG^a,b,c, Xiao-Li LI^a,b,c

a Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Plant Germplasm and Genomics Center, the Germplasm Bank of Wild Species, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
c Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
d Biology Institute of Shandong Academy of Sciences, Jinan 250014, China

Received:2013-01-22 Revised:2013-03-28 Online:2013-06-24 Published:2018-02-11
Supported by:
This work was supported by the Basic Research Project of the Ministry of Science and Technology of China (2012FY110300), MOST grant (2008BAD98B06).

摘要/Abstract

摘要： Phytochemical investigation of the aerial parts of Euphorbia sikkimensis led to the isolation of one new diterpenoids, named sikkimenoid E (1), together with thirteen other known compounds (2-14). Their structures were established by means of spectroscopic methods. Compound 2 was identified to be a trinortriterpenoid, and derived for the first time from a natural source. In this paper we reveal for the first time its comprehensive spectral data and NMR spectral assignment. Compound 4 showed antiangiogenic activity with an IC₅₀ value of 5.66 μM in a zebrafish model, and compounds 5 and 6 exhibited cytotoxicity toward A549 cell line with IC₅₀ values of 12.12 and 6.45 μM, respectively.

关键词: Euphorbia sikkimensis, ingenol, trinortriterpenoid, tocopherol derivatives, bioactivities

Abstract: Phytochemical investigation of the aerial parts of Euphorbia sikkimensis led to the isolation of one new diterpenoids, named sikkimenoid E (1), together with thirteen other known compounds (2-14). Their structures were established by means of spectroscopic methods. Compound 2 was identified to be a trinortriterpenoid, and derived for the first time from a natural source. In this paper we reveal for the first time its comprehensive spectral data and NMR spectral assignment. Compound 4 showed antiangiogenic activity with an IC₅₀ value of 5.66 μM in a zebrafish model, and compounds 5 and 6 exhibited cytotoxicity toward A549 cell line with IC₅₀ values of 12.12 and 6.45 μM, respectively.

Key words: Euphorbia sikkimensis, ingenol, trinortriterpenoid, tocopherol derivatives, bioactivities

Da-Song YANG, Wei-Bing PENG, Zi-Lei LI, Xue WANG, Jian-Guo WEI, Ke-Chun LIU, Yong-Ping YANG, Xiao-Li LI. Chemical constituents from the aerial parts of Euphorbia sikkimensis and their bioactivities[J]. 应用天然产物, 2013, 3(3): 112-116.

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Chemical constituents from the aerial parts of Euphorbia sikkimensis and their bioactivities

Chemical constituents from the aerial parts of Euphorbia sikkimensis and their bioactivities

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