Two new neolignans from Manglietia insignis

doi:10.1007/s13659-012-0063-7

应用天然产物 ›› 2012, Vol. 2 ›› Issue (5): 227-230.DOI: 10.1007/s13659-012-0063-7

• Short Communication • 上一篇

Two new neolignans from Manglietia insignis

Shan-Zhai SHANG^a,b, Ju-Ming YAN^a,b, Hai-Bo ZHANG^a, Yi-Ming SHI^a,b, Zhong-Hua GAO^a,b, Xue DU^a, Yan LI^a, Wei-Lie XIAO^a, Han-Dong SUN^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, China;
b University of Chinese Academy of Sciences, Beijing 100049, China

收稿日期:2012-07-26 修回日期:2012-10-17 出版日期:2012-10-24 发布日期:2018-02-11
通讯作者: Wei-Lie XIAO,E-mail:xwl@mail.kib.ac.cn;Han-Dong SUN,E-mail:hdsun@mail.kib.ac.cn
基金资助:
This project was supported financially by the NSFC(No. 20802082 and 30830115), the projects from the Chinese Academy of Sciences(KSCX2-EW-Q-10 and KSCX1-YW-R-24), the Major State Basic Research Development Program of China(No. 2009CB522300 and 2009CB940900), and the Natural Science Foundation of Yunnan Province(2012FB178 and 20080A007) and the project of recruited top talent of sciences and technology of Yunnan Province(2009C1120).

Two new neolignans from Manglietia insignis

Shan-Zhai SHANG^a,b, Ju-Ming YAN^a,b, Hai-Bo ZHANG^a, Yi-Ming SHI^a,b, Zhong-Hua GAO^a,b, Xue DU^a, Yan LI^a, Wei-Lie XIAO^a, Han-Dong SUN^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, China;
b University of Chinese Academy of Sciences, Beijing 100049, China

Received:2012-07-26 Revised:2012-10-17 Online:2012-10-24 Published:2018-02-11
Supported by:
This project was supported financially by the NSFC(No. 20802082 and 30830115), the projects from the Chinese Academy of Sciences(KSCX2-EW-Q-10 and KSCX1-YW-R-24), the Major State Basic Research Development Program of China(No. 2009CB522300 and 2009CB940900), and the Natural Science Foundation of Yunnan Province(2012FB178 and 20080A007) and the project of recruited top talent of sciences and technology of Yunnan Province(2009C1120).

摘要/Abstract

摘要： Two new neolignans, manneoinsigins A(1) and B(2), together with four known lignans, were isolated from the leaves and stems of Manglietia insignis. The new compounds were established on the basis of extensive spectroscopic analyses. All compounds except 2 were tested for their cytotoxic activity. Compound 3 showed weak cytotoxic activity against the HL-60 human tumor cell line with the IC₅₀ value of 23.5 μM.

关键词: Magnoliaceae, Manglietia insignis, neolignan, cytotoxic activity

Abstract: Two new neolignans, manneoinsigins A(1) and B(2), together with four known lignans, were isolated from the leaves and stems of Manglietia insignis. The new compounds were established on the basis of extensive spectroscopic analyses. All compounds except 2 were tested for their cytotoxic activity. Compound 3 showed weak cytotoxic activity against the HL-60 human tumor cell line with the IC₅₀ value of 23.5 μM.

Key words: Magnoliaceae, Manglietia insignis, neolignan, cytotoxic activity

Shan-Zhai SHANG, Ju-Ming YAN, Hai-Bo ZHANG, Yi-Ming SHI, Zhong-Hua GAO, Xue DU, Yan LI, Wei-Lie XIAO, Han-Dong SUN. Two new neolignans from Manglietia insignis[J]. 应用天然产物, 2012, 2(5): 227-230.

Shan-Zhai SHANG, Ju-Ming YAN, Hai-Bo ZHANG, Yi-Ming SHI, Zhong-Hua GAO, Xue DU, Yan LI, Wei-Lie XIAO, Han-Dong SUN. Two new neolignans from Manglietia insignis[J]. Natural Products and Bioprospecting, 2012, 2(5): 227-230.

参考文献

[1] Youn, U. J.; Chen, Q. C.; Jin, W. Y.; Lee, I. S.; Kim, H. J.; Lee, J. P.; Chang, M. J.; Min, B. S.; Bae, K. H. J. Nat. Prod. 2007, 70, 1687-1689.
[2] Watanabe, K.; Watanabe, H. Y.; Goto, Y.; Yamamoto, N.; Yoshizaki, M. Jpn. J. Pharmacol. 1975, 25, 605-607.
[3] Watanabe, K.; Watanabe, H.; Goto, Y.; Yamaguchi, M.; Yamamoto, N.; Hagino, K. Planta Med. 1983, 49, 103-108.
[4] Watanabe, K. Gendai Toyo Igaku 1986, 7, 54-59.
[5] Teng, C. M.; Yu, S. M.; Chen, C. C.; Huang, Y. L.; Huang, T. F. Life Sci. 1990, 47, 1153-1161.
[6] Bae, E. A.; Han, M. J.; Kim, D. H. Planta Med. 1999, 65, 442-443.
[7] Namba, T.; Tsunezuka, M.; Hattori, M. Planta Med. 1982, 44, 100-106.
[8] Sohn, E. J.; Kim, C. S.; Kim, Y. S.; Jung, D. H.; Jang, D. S.; Lee,Y. M.; Kim, J. S. Life Sci. 2007, 80, 468-475.
[9] Fukuyama, Y.; Otoshi, Y.; Miyoshi, K.; Nakamura, K.; Kodama, M.; Nagasawa, M.; Hasegawa, T.; Okazaki, H.; Sugawara, M. Tetrahedron 1992, 48, 377-392.
[10] College, J. N. M. Ed. Chinese Drug Dictionary. Shanghai Science and Technology Publishing Co. 1977, 1628-1630.
[11] Vardamides, J. C.; Azebaze, A. G. B.; Nkengfack, A. E.; Van Heerden, F. R.; Fomum, Z. T.; Ngando, T. M.; Conrad, J.; Vogler, B.; Kraus, W. Phytochemistry 2003, 62, 647-650.
[12] Sugahara, T.; Yamauchi, S.; Kondo, A.; Ohno, F.; Tominaga, S.; Nakashima, Y.; Kishida, T.; Akiyama, K.; Maruyama, M. Biosci. Biotechnol. Biochem. 2007, 71, 2962-2968.
[13] Masuda, T.; Akiyama, J.; Fujimoto, A.; Yamauchi, S.; Maekawa, T.; Sone, Y. Food Chem. 2010, 123, 442-450.
[14] Luo, X.; Wu, S.; Ma, Y.; Wu, D. Acta. Bot. Yunnanica 2001, 23, 368-372.
[15] Deng, X. M.; Cheng, Y. X.; Zhou, J.; Tan, N. H.; Ding, Z. T. Acta Bot. Yunnanica 2001, 23, 121-125.
[16] Shen, C. C.; Ni, C. L.; Shen, Y. C.; Huang, Y. L.; Kuo, C. H.; Wu, T. S.; Chen, C. C. J. Nat. Prod. 2009, 72, 168-171.
[17] Otsuka, H.; Takeuchi, M.; Inoshiri, S.; Sato, T.; Yamasaki, K. Phytochemistry 1989, 28, 883-886.
[18] Takeshita, M.; Yaguchi, R.; Akutsu, N. Tetrahedron:Asymmetry 1992, 3, 1369-1372.
[19] Ping, Z. R.; Hongjie, Z.; Zhongwen, L.; Yulin, Z.; Handong, S. Phytochemistry 1992, 31, 4237-4240.
[20] Reed, L. J.; Muench, H., In Am. J. Hyg. 1938, 27, 493-497.

Two new neolignans from Manglietia insignis

Two new neolignans from Manglietia insignis

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